8088期

最新文章

• Chen-Ning Yang obituary: intuitive physicist whose work was inspired by the beauty of symmetry AI翻译
  作者：Sutton, Christine
• Transcriptomic and spatial organization of telencephalic GABAergic neurons AI翻译
  作者：Van Velthoven, Cindy T. J.; Gao, Yuan; Kunst, Michael; Lee, Changkyu; Mcmillen, Delissa; Chakka, Anish Bhaswanth; Casper, Tamara; Clark, Michael; Chakrabarty, Rushil; Daniel, Scott; Dolbeare, Tim; Ferrer, Rebecca; Gloe, Jessica; Goldy, Jeff; Guzman, Junitta; Halterman, Carliana; Ho, Windy; Huang, Mike J.; James, Katelyn; Mccue, Rachel; Nguy, Beagan; Cardenas, Trangthanh; Ronellenfitch, Kara; Thomas, Emma D.; Torkelson, Amy; Pagan, Chelsea M.; Kruse, Lauren; Dee, Nick; Ng, Lydia; Waters, Jack; Smith, Kimberly A.; Tasic, Bosiljka; Yao, Zizhen; Zeng, Hongkui
  作者单位：Allen Institute for Brain Science
  摘要：The telencephalon of the mammalian brain contains multiple regions and circuits that have adaptive and integrative roles in a variety of brain functions. GABAergic neurons in the telencephalon are diverse; they have many circuit functions, and dysfunction of these neurons has been implicated in various brain disorders1, 2-3. Here we conducted a systematic and in-depth analysis of the transcriptomic and spatial organization of GABAergic neuronal types in all regions of the mouse telencephalon a...
• Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus (Sept, 10.1038/s41586-025-09513-x, 2025) AI翻译
  作者：Wang, Qintao; Zhu, Honghao; Sun, Xiangwei; Zhang, Changming; Ma, Shuangyue; Jin, Ying; Fu, Jinjian; Liu, Chenlu; Peng, Jiahui; Wang, Ruoran; Liu, Lin; Zeng, Yi; Gong, Cheng; Zhou, Qing; Yu, Xiaomin; Liu, Zhihong
• Molecular and cellular dynamics of the developing human neocortex AI翻译
  作者：Wang, Li; Wang, Cheng; Moriano, Juan A.; Chen, Songcang; Zuo, Guolong; Cebrian-Silla, Arantxa; Zhang, Shaobo; Mukhtar, Tanzila; Wang, Shaohui; Song, Mengyi; de Oliveira, Lilian Gomes; Bi, Qiuli; Augustin, Jonathan J.; Ge, Xinxin; Paredes, Mercedes F.; Huang, Eric J.; Alvarez-Buylla, Arturo; Duan, Xin; Li, Jingjing; Kriegstein, Arnold R.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of Barcelona; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Universidade de Sao Paulo; Institute Biomed Science, University Sao Paulo; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：The development of the human neocortex is highly dynamic, involving complex cellular trajectories controlled by gene regulation1. Here we collected paired single-nucleus chromatin accessibility and transcriptome data from 38 human neocortical samples encompassing both the prefrontal cortex and the primary visual cortex. These samples span five main developmental stages, ranging from the first trimester to adolescence. In parallel, we performed spatial transcriptomic analysis on a subset of the...
• Safeguards for virology must be designed in partnership with the public AI翻译
  作者：Atuire, Caesar Alimsinya; Ewbank, Jonathan
  作者单位：University of Oxford
• AI chatbots are sycophants - researchers say it's harming science AI翻译
  作者：Naddaf, Miryam
• Structures of α-synuclein filaments from multiple system atrophy (vol 585, pg 464, 2020) AI翻译
  作者：Schweighauser, Manuel; Shi, Yang; Tarutani, Airi; Kametani, Fuyuki; Murzin, Alexey G.; Ghetti, Bernardino; Matsubara, Tomoyasu; Tomita, Taisuke; Ando, Takashi; Hasegawa, Kazuko; Murayama, Shigeo; Yoshida, Mari; Hasegawa, Masato; Scheres, Sjors H. W.; Goedert, Michel
  作者单位：MRC Laboratory Molecular Biology; Tokyo Metropolitan Institute of Medical Science; University of Tokyo; Indiana University System; Indiana University Bloomington; Tokyo Metropolitan Institute of Gerontology; Nagoya University; Sagamihara National Hospital; Aichi Medical University
• The new frontier in understanding human and mammalian brain development AI翻译
  作者：Nowakowski, Tomasz J.; Nano, Patricia R.; Matho, Katherine S.; Chen, Xiaoyin; Corrigan, Emily K.; Ding, Wubin; Gao, Yuan; Heffel, Matthew; Jayakumar, Jaikishan; Kaplan, Harris S.; Kronman, Fae N.; Kovner, Rothem; Mannens, Camiel C. A.; Song, Mengyi; Steyert, Marilyn R.; Venkatesan, Sridevi; Wallace, Jenelle L.; Wang, Li; Werner, Jonathan M.; Zhang, Di; Yuan, Guohua; Zuo, Guolong; Ament, Seth A.; Colantuoni, Carlo; Dulac, Catherine; Fan, Rong; Gillis, Jesse; Kriegstein, Arnold R.; Krienen, Fenna M.; Kim, Yongsoo; Linnarsson, Sten; Mitra, Partha P.; Pollen, Alex A.; Sestan, Nenad; Tward, Daniel J.; Van Velthoven, Cindy T. J.; Yao, Zizhen; Bhaduri, Aparna; Zeng, Hongkui
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Children's Hospital Los Angeles; University of Southern California; Allen Institute for Brain Science; University of California System; University of California San Francisco; Salk Institute; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Harvard University; Harvard University; Howard Hughes Medical Institute; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Yale University; Karolinska Institutet; Flanders Institute for Biotechnology (VIB); KU Leuven; University of Toronto; University of Toronto; University System of Maryland; University of Maryland Baltimore; Yale University; University System of Maryland; University of Maryland Baltimore; Johns Hopkins University; Johns Hopkins Medicine; Princeton University; Cold Spring Harbor Laboratory; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of Washington; University of Washington Seattle
  摘要：Neurodevelopmental disorders that cause cognitive, behavioural or motor impairments affect around 15% of children and adolescents worldwide1, with diagnoses of profound autism and attention deficit hyperactivity disorder increasing in the USA and contributing to a major economic burden2,3. Yet the origins and mechanisms of these conditions remain poorly understood, limiting progress in therapies. Comprehensive cell atlases of the developing human brain, alongside those of model organisms such ...
• How the rush for critical minerals is neglecting human needs AI翻译
  作者：Franks, Daniel M.; Rogers, Paul; Weldegiorgis, Fitsum; Lawson, Lynda; Gallagher, Louise; Gardner, Natalie; Aska, Bora; Linus, Johanna H.; Varshney, Shrey
• Images for AI use can be sourced responsibly AI翻译
  作者：[Anonymous]