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作者:Tassel, Cecile; Jaffrezo, Jean-Luc; Dominutti, Pamela; Daellenbach, Kaspar R.; Darfeuil, Sophie; Elazzouzi, Rhabira; Laj, Paolo; Marsal, Anouk; Mhadhbi, Takoua; Dinh, Vy Ngoc Thuy; Voiron, Celine; Houdier, Stephan; Durif, Marc; Chatain, Melodie; Francony, Florie; Cozic, Julie; Salque Moreton, Guillaume; Le Quilleuc, Meryll; Ghersi, Veronique; Gille, Gregory; Mesbah, Boualem; Stratigou, Evdokia; Zublena, Manuela; Diemoz, Henri; Alastuey, Andres; D'Anna, Barbara; Marchand, Nicolas; Conil, Sebastien; Gros, Valerie; van Os, Marloes F.; Salma, Imre; Mihalopoulos, Nikolaos; Mocnik, Grisa; Dzepina, Katja; Styszko, Katarzyna; Huglin, Christoph; Querol, Xavier; Prevot, Andre S. H.; Favez, Olivier; Siroux, Valerie; Uzu, Gaelle
作者单位:Communaute Universite Grenoble Alpes; Centre National de la Recherche Scientifique (CNRS); INRAE; Institut de Recherche pour le Developpement (IRD); Institut National Polytechnique de Grenoble; Universite Grenoble Alpes (UGA); Communaute Universite Grenoble Alpes; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite Grenoble Alpes (UGA); CNRS - National Institute for Biology (INSB); University of Helsinki; Institut National de l'Environnement Industriel et des Risques (INERIS); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Investigacion y Desarrollo Pascual Vila (CID-CSIC); CSIC - Instituto de Diagnostico Ambiental y Estudios del Agua (IDAEA); Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CEA; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Netherlands Organization Applied Science Research; Hungarian Academy of Sciences; Eotvos Lorand University; Chemical Research Center - HAS; National Observatory of Athens; University of Crete; University of Nova Gorica; AGH University of Krakow; Swiss Federal Institutes of Technology Domain; Swiss Federal Laboratories for Materials Science & Technology (EMPA)
摘要:Atmospheric particulate matter (PM), a public health concern worldwide, is at present regulated according to its mass concentration1. However, it is increasingly thought that mass concentration may not fully capture the physicochemical properties of PM linked to its health impact2. Consequently, it has been suggested to further investigate the adequacy of this metric as an unequivocal indicator of PM health effects3, 4-5. The new European regulation on air quality introduced oxidative potentia...
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作者:Wu, Yonghui
作者单位:State University System of Florida; University of Florida; State University System of Florida; University of Florida
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作者:Aderinto, Nicholas
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作者:Shimuta, Misa
作者单位:Jikei University
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作者:Witze, Alexandra
摘要:Some doctoral programmes are admitting no students at all amid uncertainty about federal science funding.
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作者:Burgard, C.; Jourdain, N. C.; Mosbeux, C.; Caillet, J.; Mathiot, P.; Kittel, C.
作者单位:Centre National de la Recherche Scientifique (CNRS); Museum National d'Histoire Naturelle (MNHN); Institut de Recherche pour le Developpement (IRD); Sorbonne Universite; Institut de Recherche pour le Developpement (IRD); INRAE; Communaute Universite Grenoble Alpes; Centre National de la Recherche Scientifique (CNRS); Institut National Polytechnique de Grenoble; Universite Grenoble Alpes (UGA); Dartmouth College; Vrije Universiteit Brussel
摘要:The disappearance of ice shelves, the floating margins of the Antarctic ice sheet that restrain the ice flow into the ocean1, 2-3, would strongly accelerate the Antarctic contribution to sea-level rise4, 5-6. Their viability in a warming world has motivated substantial work that focuses on the influence of the warming atmosphere7, 8, 9-10. Here we revisit the concept of ice-shelf viability in a holistic manner, taking into account mass loss due to both the atmosphere and the ocean to estimate ...
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作者:Schwaller, Fred; Kavanagh, Katie
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作者:Fueyo, Raquel; Wang, Sicong; Crocker, Olivia J.; Swigut, Tomek; Nakauchi, Hiromitsu; Wysocka, Joanna
作者单位:Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Howard Hughes Medical Institute
摘要:Stem cell-based human embryo models offer a unique opportunity for functional studies of the human-specific features of development. Here we genetically and epigenetically manipulate human blastoids, a 3D embryo model of the blastocyst1, to investigate the functional effect of HERVK LTR5Hs, a hominoid-specific endogenous retrovirus, on pre-implantation development. We uncover a pervasive cis-regulatory contribution of LTR5Hs elements to the hominoid-specific diversification of the epiblast tra...
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作者:Ireland, Abbie S.; Xie, Daniel A.; Hawgood, Sarah B.; Barbier, Margaret W.; Zuo, Lisa Y.; Hanna, Benjamin E.; Lucas-Randolph, Scarlett; Tyson, Darren R.; Witt, Benjamin L.; Govindan, Ramaswamy; Dowlati, Afshin; Moser, Justin C.; Thomas, Anish; Puri, Sonam; Rudin, Charles M.; Chan, Joseph M.; Elliott, Andrew; Oliver, Trudy G.
作者单位:Duke University; Utah System of Higher Education; University of Utah; Washington University (WUSTL); Siteman Cancer Center; University System of Ohio; Case Western Reserve University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); H Lee Moffitt Cancer Center & Research Institute; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center
摘要:Neuroendocrine and tuft cells are rare chemosensory epithelial lineages defined by the expression of ASCL1 and POU2F3 transcription factors, respectively. Neuroendocrine cancers, including small cell lung cancer (SCLC), frequently display tuft-like subsets, a feature linked to poor patient outcomes1, 2, 3, 4, 5, 6, 7, 8-9. The mechanisms driving neuroendocrine-tuft tumour heterogeneity and the origins of tuft-like cancers are unknown. Using multiple genetically engineered animal models of SCLC...
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作者:Mi, Jinshuo; Yang, Jun; Chen, Likun; Cui, Wenting; Li, Yuhang; An, Xufei; Ma, Jiabin; Yang, Ke; Xie, Yaoshu; Biao, Jie; Long, Yu; Ge, Huilin; Han, Bing; Ke, Ruohong; Xiao, Guanyou; Tan, Shendong; Zhang, Danfeng; Cheng, Xing; Hou, Tingzheng; Huang, Yan-Fei; Liu, Ming; Lv, Wei; Gan, Lin; He, Yan-Bing; Yang, Quan-Hong; Kang, Feiyu
作者单位:Tsinghua University; Tsinghua Shenzhen International Graduate School; Tsinghua University; Tianjin University; Eastern Institute of Technology, Ningbo; Eastern Institute for Advanced Study; Shenzhen University; Nankai University; Haihe Laboratory of Sustainable Chemical Transformations
摘要:Solid-state lithium metal batteries are facing huge challenges under practical working conditions1,2. Even when the ionic conductivity of composite solid-state electrolytes is increased to 1 mS cm-1, it is still difficult to realize long-life cycling of solid-state batteries above a current density of 1 mA cm-2 and an areal capacity of 1 mAh cm-2 (ref. 3). The fundamental cause is the brittle nature of the solid-electrolyte interphase (SEI) with sluggish lithium-ion transport and the resulting...