作者：Shmatko, Artem; Jung, Alexander Wolfgang; Gaurav, Kumar; Brunak, Soren; Mortensen, Laust Hvas; Birney, Ewan; Fitzgerald, Tom; Gerstung, Moritz
作者单位：Helmholtz Association; German Cancer Research Center (DKFZ); European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; Ruprecht Karls University Heidelberg; University of Copenhagen; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Copenhagen; Ruprecht Karls University Heidelberg; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Eberhard Karls University Hospital
摘要：Decision-making in healthcare relies on understanding patients' past and current health states to predict and, ultimately, change their future course1, 2-3. Artificial intelligence (AI) methods promise to aid this task by learning patterns of disease progression from large corpora of health records4,5. However, their potential has not been fully investigated at scale. Here we modify the GPT6 (generative pretrained transformer) architecture to model the progression and competing nature of human...
作者：Keefe, Matthew G.; Steyert, Marilyn R.; Nowakowski, Tomasz J.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：The human neocortex is composed of diverse cell types1 that are generated during development according to spatially and temporally organized programmes initiated by neural stem cells2, 3, 4-5. Despite the growing number of studies that have captured snapshots of gene expression of single cells along the axis of differentiation and maturation, the underlying map of lineage relationships that link individual progenitor cells to specific subtypes of neurons and glia remains unknown, especially in...
作者：Savige, Tom; Quigley, Mark; Werner, Tim T.
作者单位：University of Melbourne
作者：Bachstetter, Adam; Morganti, Josh
作者单位：University of Kentucky; University of Kentucky; University of Kentucky
