8088期

最新文章

• Developmental maps of the brain trace when cell types emerge AI翻译
  作者：Sylwestrak, Emily
  作者单位：University of Oregon; University of Oregon
• Covariation MS uncovers a protein that controls cysteine catabolism AI翻译
  作者：Xiao, Haopeng; Ordonez, Martha; Fink, Emma C.; Covington, Taylor A.; Woldemichael, Hilina B.; Chen, Junyi; Jain, Mika Sarkin; Rohatgi, Milan H.; Wei, Shelley M.; Burger, Nils; Sharif, Muneeb A.; Jan, Julius; Wang, Yaoyu; Petrocelli, Jonathan J.; Blackmore, Katherine; Smythers, Amanda L.; Zhang, Bingsen; Gilbert, Matthew; Cheong, Hakyung; Khetarpal, Sumeet A.; Smith, Arianne; Bogoslavski, Dina; Lei, Yu; Vaites, Laura Pontano; Mcallister, Fiona E.; Van Bruggen, Nick; Donovan, Katherine A.; Huttlin, Edward L.; Mills, Evanna L.; Fischer, Eric S.; Chouchani, Edward T.
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Stanford Medicine; Stanford University; Stanford University; Stanford Cancer Institute; Stanford Medicine; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Stanford University; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Howard Hughes Medical Institute
  摘要：The regulation of metabolic processes by proteins is fundamental to biology and yet is incompletely understood. Here we develop a mass spectrometry (MS)-based approach that leverages genetic diversity to nominate functional relationships between 285 metabolites and 11,868 proteins in living tissues. This method recapitulates protein-metabolite functional relationships mediated by direct physical interactions and local metabolic pathway regulation while nominating 3,542 previously undescribed r...
• Dismantling of US federal agencies will 'destroy science' AI翻译
  作者：Gewin, Virginia
• Ultrashort laser pulse amplified by back-and-forth propagation AI翻译
  作者：Heyl, Christoph; Hanna, Marc
  作者单位：Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay
• A tweezer array with 6,100 highly coherent atomic qubits AI翻译
  作者：Manetsch, Hannah J.; Nomura, Gyohei; Bataille, Elie; Lv, Xudong; Leung, Kon H.; Endres, Manuel
  作者单位：California Institute of Technology; Chinese Academy of Sciences; Shanghai Institute of Optics & Fine Mechanics, CAS
  摘要：Optical tweezer arrays1,2 have transformed atomic and molecular physics, now forming the backbone for a range of leading experiments in quantum computing3, 4, 5, 6, 7-8, simulation1,9, 10, 11-12 and metrology13, 14-15. Typical experiments trap tens to hundreds of atomic qubits and, recently, systems with around 1,000 atoms were realized without defining qubits or demonstrating coherent control16, 17-18. However, scaling to thousands of atomic qubits with long coherence times and low-loss and h...
• The importance of past rifting in large igneous province development AI翻译
  作者：Kounoudis, R.; Bastow, I. D.; Ebinger, C. J.; Goes, S.; Zhou, P.; Musila, M.; Ogden, C. S.; Ayele, A.
  作者单位：University of Oxford; Imperial College London; Tulane University; Addis Ababa University
  摘要：Lithospheric thin zones, such as recently failed rifts, are generally assumed to be weak spots where magmatism and deformation can concentrate during rifting and large igneous province development1, 2-3. Yet, the Turkana Depression in East Africa, the site of the failed 66-million-year-old Anza Rift, did not experience the widespread flood magmatism seen on the adjacent Ethiopian Plateau, despite being a lithospheric thin spot when the region encountered hot plume material around 45 million ye...
• From pangolins to primates: how I use zoo facilities to treat wild animals AI翻译
  作者：Leeming, Jack
• PhD training needs a reboot in an AI world AI翻译
  作者：Sen Gupta, Alex
  作者单位：University of New South Wales Sydney
• Repeated head trauma causes neuron loss and inflammation in young athletes AI翻译
  作者：Butler, Morgane L. M. D.; Pervaiz, Nida; Breen, Kerry; Calderazzo, Samantha; Ypsilantis, Petra; Wang, Yichen; Breda, Julia Cammasola; Mazzilli, Sarah; Nicks, Raymond; Spurlock, Elizabeth; Hefti, Marco M.; Fiock, Kimberly L.; Huber, Bertrand R.; Alvarez, Victor E.; Stein, Thor D.; Campbell, Joshua D.; McKee, Ann C.; Cherry, Jonathan D.
  作者单位：Boston University; Boston University; Boston University; Boston University; Boston University; Harvard University; US Department of Veterans Affairs; Harvard University Medical Affiliates; Veterans Health Administration (VHA); VA Boston Healthcare System; University of Iowa; University of Iowa; University of Iowa; Harvard University; US Department of Veterans Affairs; Harvard University Medical Affiliates; Veterans Health Administration (VHA); VA Boston Healthcare System; Boston University
  摘要：Repetitive head impacts (RHIs) sustained from contact sports are the largest risk factor for chronic traumatic encephalopathy (CTE)1, 2, 3-4. Currently, CTE can only be diagnosed after death and the events that trigger initial hyperphosphorylated tau (p-tau) deposition remain unclear2. Furthermore, the symptoms endorsed by young individuals are not fully explained by the extent of p-tau deposition2, severely hampering therapeutic interventions. Here we observed a multicellular response prior t...
• How Napoleon's army met its doom: DNA reveals surprise illnesses had a role AI翻译
  作者：Ahart, Jenna