作者:Kok, Adinda; Wilks, Samuel H.; Tureli, Sina; James, Sarah L.; Bestebroer, Theo M.; Burke, David F.; Funk, Mathis; van der Vliet, Stefan; Spronken, Monique I.; Rijnink, Willemijn F.; Pattinson, David J.; de Meulder, Dennis; Rosu, Miruna E.; Lexmond, Pascal; van den Brand, Judith M. A.; Herfst, Sander; Smith, Derek J.; Fouchier, Ron A. M.; Richard, Mathilde
作者单位:Erasmus University Rotterdam; Erasmus MC; University of Cambridge; Utrecht University; Utrecht University; University of Melbourne; University of London; Guy's & St Thomas' NHS Foundation Trust; King's College London; University of Wisconsin System; University of Wisconsin Madison
摘要:Highly pathogenic avian influenza A(H5) viruses globally impact wild and domestic birds, and have caused severe infections in mammals, including humans, underscoring their pandemic potential1, 2, 3, 4-5. The antigenic evolution of the A(H5) haemagglutinin (HA) poses challenges for pandemic preparedness and vaccine design6. Here the global antigenic evolution of the A(H5) HA was captured in a high-resolution antigenic map. The map was used to design immunogenic and antigenically central vaccine...
作者:Karasikov, Mikhail; Mustafa, Harun; Danciu, Daniel; Kulkov, Oleksandr; Zimmermann, Marc; Barber, Christopher; Ratsch, Gunnar; Kahles, Andre
作者单位:Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Institute of Bioinformatics; University of Zurich; University Zurich Hospital; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要:The amount of biological sequencing data available in public repositories is growing rapidly, forming a critical resource for biomedicine. However, making these data efficiently and accurately full-text searchable remains challenging. Here we build on efficient data structures and algorithms for representing large sequence sets1, 2, 3, 4, 5-6. We present MetaGraph, a methodological framework that enables us to scalably index large sets of DNA, RNA or protein sequences using annotated de Bruijn...
作者:Brown, Kerry
作者单位:University of London; King's College London; University of London; King's College London
作者:De Lucia, Vito; Solski, Jan
作者单位:UiT The Arctic University of Tromso