作者：Kok, Adinda; Wilks, Samuel H.; Tureli, Sina; James, Sarah L.; Bestebroer, Theo M.; Burke, David F.; Funk, Mathis; van der Vliet, Stefan; Spronken, Monique I.; Rijnink, Willemijn F.; Pattinson, David J.; de Meulder, Dennis; Rosu, Miruna E.; Lexmond, Pascal; van den Brand, Judith M. A.; Herfst, Sander; Smith, Derek J.; Fouchier, Ron A. M.; Richard, Mathilde
作者单位：Erasmus University Rotterdam; Erasmus MC; University of Cambridge; Utrecht University; Utrecht University; University of Melbourne; University of London; Guy's & St Thomas' NHS Foundation Trust; King's College London; University of Wisconsin System; University of Wisconsin Madison
摘要：Highly pathogenic avian influenza A(H5) viruses globally impact wild and domestic birds, and have caused severe infections in mammals, including humans, underscoring their pandemic potential1, 2, 3, 4-5. The antigenic evolution of the A(H5) haemagglutinin (HA) poses challenges for pandemic preparedness and vaccine design6. Here the global antigenic evolution of the A(H5) HA was captured in a high-resolution antigenic map. The map was used to design immunogenic and antigenically central vaccine...
作者：Karasikov, Mikhail; Mustafa, Harun; Danciu, Daniel; Kulkov, Oleksandr; Zimmermann, Marc; Barber, Christopher; Ratsch, Gunnar; Kahles, Andre
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Institute of Bioinformatics; University of Zurich; University Zurich Hospital; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：The amount of biological sequencing data available in public repositories is growing rapidly, forming a critical resource for biomedicine. However, making these data efficiently and accurately full-text searchable remains challenging. Here we build on efficient data structures and algorithms for representing large sequence sets1, 2, 3, 4, 5-6. We present MetaGraph, a methodological framework that enables us to scalably index large sets of DNA, RNA or protein sequences using annotated de Bruijn...
作者：Brown, Kerry
作者单位：University of London; King's College London; University of London; King's College London
作者：De Lucia, Vito; Solski, Jan
作者单位：UiT The Arctic University of Tromso
