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作者:Perrenoud, Quentin; Fonseca, Antonio H. de O.; Airhart, Austin; Bonanno, James; Mao, Rong; Cardin, Jessica A.
作者单位:Yale University
摘要:Cognitive processes underlying behaviour are linked to specific spatiotemporal patterns of neural activity in the neocortex1, 2, 3, 4, 5-6. These patterns arise from synchronous synaptic activity7 and are often analysed as oscillations, but may also display aperiodic dynamics that are not well detected. Here we develop a novel analytical method decomposing patterned activity into discrete network events and use this approach to track gamma activity (30-80 Hz) in the mouse visual cortex (V1). W...
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作者:Hadzibabic, Zoran; Schneider, Ulrich
作者单位:University of Cambridge
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作者:Zhou, Xufei; Diao, Rucheng; Li, Xin; Ziegler, Christine A.; Gramelspacher, Max J.; Freddolino, Lydia; Hou, Zhonggang; Zhang, Yan
作者单位:University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
摘要:Prokaryotes create adaptive immune memories by acquiring foreign DNA snippets, known as spacers, into the CRISPR array1. In type II CRISPR-Cas systems, the RNA-guided effector Cas9 also assists the acquisition machinery by selecting spacers from the protospacer adjacent motif-flanked DNA2,3. Here we uncovered the first biological role of Cas9 that is independent of its dual RNA partners. Following depletion of CRISPR RNA (crRNA) and/or trans-activating CRISPR RNA, Neisseria apoCas9 stimulates ...
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作者:Rovny, Jared; Kolkowitz, Shimon; De Leon, Nathalie P.
作者单位:Princeton University; University of California System; University of California Berkeley
摘要:Nitrogen vacancy (NV) centres in diamond are widely deployed as local magnetic sensors, using single-qubit control to measure both time-averaged fields and noise with nanoscale spatial resolution1. Moving beyond single qubits to multi-qubit control enables new sensing modalities such as measuring nonlocal spatiotemporal correlators2 or using entangled states to enhance measurement sensitivity3. Here we describe protocols for using optically unresolved NV centre pairs and nuclear spins as multi...
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作者:White, Malcolm F.
作者单位:University of St Andrews