作者：Allen, Liz; Kiermer, Veronique; Porter, Simon; Whittam, Ruth
作者：Moore, Madelyn N.; Person, Kelsey L.; Robleto, Valeria L.; Alwin, Abigail R.; Krusemark, Campbell L.; Foster, Noah; Ray, Caroline; Inoue, Asuka; Jackson, Michael R.; Sheedlo, Michael J.; Barak, Lawrence S.; Marron Fernandez de Velasco, Ezequiel; Olson, Steven H.; Slosky, Lauren M.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; Duke University; Tohoku University; Kyoto University; Sanford Burnham Prebys Medical Discovery Institute
摘要：G-protein-coupled receptors (GPCRs) convert extracellular signals into intracellular responses by signalling through 16 subtypes of G alpha proteins and two beta-arrestin proteins. Biased compounds-molecules that preferentially activate a subset of these proteins-engage therapy-relevant pathways more selectively1 and promise to be safer, more effective medications than compounds that uniformly activate all pathways2. However, the determinants of bias are poorly understood, and we lack rational...
作者：Jemielniak, Dariusz
作者单位：Polish Academy of Sciences; Harvard University
作者：Rawls, Meredith
作者单位：University of Washington; University of Washington Seattle
作者：Hota, Swetansu K.; Rao, Kavitha S.; Blair, Andrew P.; Khalilimeybodi, Ali; Hu, Kevin M.; Thomas, Reuben; So, Kevin; Kameswaran, Vasumathi; Xu, Jiewei; Polacco, Benjamin J.; Desai, Ravi V.; Chatterjee, Nilanjana; Hsu, Austin; Muncie, Jonathon M.; Blotnick, Aaron M.; Winchester, Sarah A. B.; Weinberger, Leor S.; Huttenhain, Ruth; Kathiriya, Irfan S.; Krogan, Nevan J.; Saucerman, Jeffrey J.; Bruneau, Benoit G.
