8092期

最新文章

• SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer AI翻译
  作者：Li, Huafu; Lan, Linxiang; Chen, Hengxing; May, Zaw Thin; Hari, Ps; Nelson, Jessica K.; Evans, Ian M.; Ruiz, E. Josue; Cheng, Rongjie; Tran, Li; Allen, Mark; Ma, Jian; Yi, Tingzhuang; Wang, Chunming; He, Yulong; Guppy, Naomi; Sadanandam, Anguraj; Lin, Shao-Zhen; Zhang, Changhua; Behrens, Axel
  作者单位：Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; Sun Yat Sen University; University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; National University of Singapore; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; CNRS - Institute of Physics (INP); Imperial College London; Imperial College London; Youjiang Medical University for Nationalities; Guangxi Medical University; Sun Yat Sen University
  摘要：Elucidating the complex network of communication between tumour cells is central to understanding cell fate decisions and progression of pancreatic ductal adenocarcinoma (PDAC)1,2. We previously showed that constant suppression of BMP activity by the BMP antagonist GREM1 secreted by mesenchymal PDAC cells is essential for maintaining the fate of epithelial PDAC cells3. Here we identify SPP1 (also known as osteopontin)4 as a key regulator of mesenchymal cell fate in pancreatic cancer. Proteomic...
• Climbing through the silver mine: my work as a geologist AI翻译
  作者：Tacon, Dave; Erdenetulkhuur, Enkhbayar
• A matrix-confined molecular layer for perovskite photovoltaic modules AI翻译
  作者：Liang, Yugang; Chen, Guodong; Wang, Yao; Zou, Yu; Feng, Menglei; Wang, Yanming; Li, Bowei; Cho, Yuljae; Chang, Yide; Liu, Tianle; Zhang, Taiyang; Lou, Yongbing; Xu, Ranran; Lu, Lei; Zhang, Ni; Meng, Ke; Zhu, Chen; Ouyang, Chuying; Miao, Yanfeng; Guo, Yongsheng; Chen, Yuetian; Zhao, Yixin
  作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Institute of Technology; Southeast University - China; Jiangxi Normal University
  摘要：Metal halide perovskites with remarkable optoelectronic properties have become a competitive candidate for supporting the efficiency progression of photovoltaics. As the latest reported power conversion efficiency of research cells is comparable to that of commercialized silicon cells1, 2-3, the industrialization of perovskite solar cells is on the horizon4,5. However, most high-efficiency inverted perovskite solar cells based on self-assembled molecules (SAMs) face challenges owing to the agg...
• Lymphoid gene expression supports neuroprotective microglia function AI翻译
  作者：Ayata, Pinar; Crowley, Jessica M.; Challman, Matthew F.; Sahasrabuddhe, Vinaya; Gratuze, Maud; Werneburg, Sebastian; Ribeiro, Diogo; Hays, Emma C.; Duran-Laforet, Violeta; Faust, Travis E.; Hwang, Philip; Mendes Lopes, Francisco; Nikopoulou, Chrysa; Buchholz, Sarah; Murphy, Robert E.; Mei, Taoyu; Pimenova, Anna A.; Romero-Molina, Carmen; Garretti, Francesca; Patel, Tulsi A.; De Sanctis, Claudia; Ramirez Jimenez, Angie V.; Crow, Megan; Weiss, Felix D.; Ulrich, Jason D.; Marcora, Edoardo; Murray, John W.; Meissner, Felix; Beyer, Andreas; Hasson, Dan; Crary, John F.; Schafer, Dorothy P.; Holtzman, David M.; Goate, Alison M.; Tarakhovsky, Alexander; Schaefer, Anne
  作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; City University of New York (CUNY) System; Washington University (WUSTL); Aix-Marseille Universite; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; University of Michigan System; University of Michigan; Max Planck Society; University of Cologne; University of Cologne; University of Cologne; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Roche Holding; Roche Holding USA; Genentech; University of Bonn; Leibniz Association; Deutsches Rheuma-Forschungszentrum (DRFZ); Columbia University; Rockefeller University
  摘要：Microglia, the innate immune cells of the brain, play a defining role in the progression of Alzheimer's disease (AD)1. The microglial response to amyloid plaques in AD can range from neuroprotective to neurotoxic2. Here we show that the protective function of microglia is governed by the transcription factor PU.1, which becomes downregulated following microglial contact with plaques. Lowering PU.1 expression in microglia reduces the severity of amyloid disease pathology in mice and is linked t...
• Tin-based perovskite solar cells with a homogeneous buried interface AI翻译
  作者：Li, Tianpeng; Luo, Xin; Wang, Peilin; Li, Zhi; Li, Yimeng; Huang, Jinhai; Jin, Zuoming; Yang, Yingguo; Li, Bin; Zhang, Wenqi; Lin, Siyuan; Rui, Yichuan; Wang, Hua; Zhang, Qinghong; Zhan, Yiqiang; Xu, Bo; Liang, Jia; Qi, Yabing
  作者单位：Fudan University; Nanjing University of Science & Technology; Tongji University; Taiyuan University of Technology; Fudan University; Chinese Academy of Sciences; Shanghai Advanced Research Institute, CAS; Donghua University; Shanghai University of Engineering Science; Fudan University; Shanghai Jiao Tong University; Shanghai Jiao Tong University
  摘要：Tin-based perovskite solar cells (TPSCs) have emerged as a promising non-toxic and environmentally friendly alternative to lead-based devices1, 2-3, with certified power conversion efficiencies (PCEs) of inverted architectures now exceeding 16% (refs. 4, 5, 6, 7-8). Despite an ideal bandgap supporting a theoretical PCE of more than 33%, TPSCs still lag in performance and stability, partly because of suboptimal hole transport layers and a poor buried interface that hinder hole extraction. Here ...
• We are all mosaics: vast genetic diversity found between cells in a single person AI翻译
  作者：Ledford, Heidi
• Ease the EU postdoc job market with better routes to innovation AI翻译
  作者：Servais, Bram
  作者单位：University of Melbourne
• Glasses-free 3D display with ultrawide viewing range using deep learning AI翻译
  作者：Ma, Weijie; Zhao, Zhangrui; Zhao, Canyu; Ouyang, Wanli; Zhong, Han-Sen
  作者单位：Fudan University; Shanghai Artificial Intelligence Laboratory; Beihang University; Zhejiang University; Chinese University of Hong Kong
  摘要：Glasses-free three-dimensional (3D) displays provide users with an immersive visual experience without the need of any wearable devices1,2. To achieve high-quality 3D imaging, a display should have both large linear dimensions and a wide viewing angle. However, the trade-off between spatial extent and bandwidth of optical systems, the space-bandwidth product, conventionally constrains the simultaneous maximization of the two. The two most common approaches to 3D displays are holographic3,4 and...
• A metallic p-wave magnet with commensurate spin helix (vol 646, pg837-842 , 2025) AI翻译
  作者：Yamada, Rinsuke; Birch, Max T.; Baral, Priya R.; Okumura, Shun; Nakano, Ryota; Gao, Shang; Ezawa, Motohiko; Nomoto, Takuya; Masell, Jan; Ishihara, Yuki; Kolincio, Kamil K.; Belopolski, Ilya; Sagayama, Hajime; Nakao, Hironori; Ohishi, Kazuki; Ohhara, Takashi; Kiyanagi, Ryoji; Nakajima, Taro; Tokura, Yoshinori; Arima, Taka-hisa; Motome, Yukitoshi; Hirschmann, Moritz M.; Hirschberger, Max
• KCTD10 is a sensor for co-directional transcription-replication conflicts AI翻译
  作者：Kloeber, Jake A.; Chen, Bin; Sun, Guangchao; King, Charles S.; Wang, Zhiquan; Wang, Li; Wu, Zheming; Zhu, Shouhai; Zhao, Fei; Qin, Hongran; Ouyang, Yaobin; Xiao, Huaping; Tu, Xinyi; Lu, Jing; Jiang, Yanxia; Luo, Kuntian; Yin, Ping; Wu, Xinyan; Mutter, Robert W.; Huang, Jinzhou; Lou, Zhenkun
  作者单位：Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic
  摘要：During DNA replication, the replisome must remove barriers and roadblocks including the transcription machinery1,2. Transcription-replication conflicts (TRCs) occur when there are collisions between the replisome and transcription machinery, and are increasingly recognized as an important source of mammalian genome instability3. How cells facilitate replisome bypass at sites of TRCs is incompletely understood. Here we show that the CUL3-KCTD10 E3 ligase senses TRCs and promotes remodelling of ...