作者：Dewa, Ken-ichi; Kaseda, Kodai; Kuwahara, Aoi; Kubotera, Hideaki; Yamasaki, Ayato; Awata, Natsumi; Komori, Atsuko; Holtz, Mika A.; Kasai, Atsushi; Skibbe, Henrik; Takata, Norio; Yokoyama, Tatsushi; Tsuda, Makoto; Numata, Genri; Nakamura, Shun; Takimoto, Eiki; Sakamoto, Masayuki; Ito, Minako; Masuda, Takahiro; Nagai, Jun
作者单位：RIKEN; Waseda University; Kyushu University; Kyushu University; Nagoya University; University of Osaka; Japan Science & Technology Agency (JST); RIKEN; Matsuyama University; Keio University; Kyoto University; Kyoto University; Kyoto University; Kyoto University; Kyushu University; Kyushu University; University of Tokyo; University of Tokyo; Institute of Science Tokyo; Johns Hopkins University; Johns Hopkins Medicine; Japan Science & Technology Agency (JST)
摘要：Recalled memories become transiently labile and require stabilization1, 2-3. The mechanism for stabilizing memories of survival-critical experiences, which are often emotionally salient and repeated, remains unclear4. Here we identify an astrocytic ensemble that is transcriptionally primed by emotional experience and functionally triggered by repeated experience to stabilize labile memory. Using a novel brain-wide Fos tagging and imaging method, we found that astrocytic Fos ensembles were pref...
作者：Mesa, Kailin R.; O'Connor, Kevin A.; Ng, Charles; Salvatore, Steven P.; Dolynuk, Alexandra; Lomeli, Michelle Rivera; Littman, Dan R.
作者单位：New York University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; New York University; Howard Hughes Medical Institute
摘要：All mammalian organs depend on resident macrophage populations to coordinate repair and facilitate tissue-specific functions1, 2-3. Functionally distinct macrophage populations reside in discrete tissue niches and are replenished through a combination of local proliferation and monocyte recruitment4,5. Declines in macrophage abundance and function have been linked to age-associated pathologies, including atherosclerosis, cancer and neurodegeneration6, 7-8. However, the mechanisms that coordina...
作者：Ning, Rongsheng; Xiang, Yingying; dos Santos, Mauricius Marques; Snyder, Shane A.
作者单位：University System of Georgia; Georgia Institute of Technology
