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作者：Kovanovic, Vitomir; Barthakur, Abhinava; Joksimovic, Srecko; Siemens, George
作者单位：Adelaide University; University of South Australia; Adelaide University; University of South Australia; Adelaide University; University of South Australia
摘要：Academia is unprepared for the rise in chatbot use among students - but with the right AI tools, personalized learning could soon become a reality.
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作者：Luchetti, Giovanni; Miner, Marin V.; Peterson, Rachael M.; Scott, William P.; Krishnamoorthy, Praveen; Kofoed, Eric M.; Jimenez, Angel G.; Zhang, Hua; Tan, Man Wah; Reja, Rohit; Cheung, Tommy K.; Skippington, Elizabeth; Liang, Yuxin; Rose, Christopher M.; Kayagaki, Nobuhiko; Newton, Kim; Rauch, Isabella; Dixit, Vishva M.
作者单位：Roche Holding; Roche Holding USA; Genentech; Oregon Health & Science University; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech
摘要：Diverse pathogen-encoded virulence factors disable apoptosis, pyroptosis or necroptosis, the host cell death programs that remove infected cells1. In the intestine, the extrusion of infected cells into the lumen for elimination provides an additional layer of host defence, but no virulence mechanisms that target the cytoskeletal changes required are known2. Here we show that the Escherichia coli ubiquitin ligase NleL is an inhibitor of intestinal epithelial cell (IEC) extrusion, targeting casp...
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作者：Santopinto, Elena
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作者：Wojcik, Genevieve L.
作者单位：Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health
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作者：Hintermann, Aurelie; Bolt, Christopher C.; Hawkins, M. Brent; Valentin, Guillaume; Lopez-Delisle, Lucille; Ryan, Madeline M.; Gitto, Sandra; Barrera Gomez, Paula; Mascrez, Benedicte; Mansour, Thomas A.; Nakamura, Tetsuya; Harris, Matthew P.; Shubin, Neil H.; Duboule, Denis
作者单位：University of Geneva; Swiss Federal Institutes of Technology Domain; Swiss School of Public Health (SSPH+); Ecole Polytechnique Federale de Lausanne; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Rutgers University System; Rutgers University New Brunswick; University of Chicago; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Centre National de la Recherche Scientifique (CNRS); College de France; Stowers Institute for Medical Research
摘要：The fin-to-limb transition in vertebrate evolution has been central to the study of how development underlies evolutionary change. In this context, the functional analysis of Hox gene regulation to infer evolutionary trajectories has been critical to explain the origin of new features. In tetrapods, the transcription of Hoxd genes in developing digits depends on a set of enhancers forming a large regulatory landscape1,2. The presence of a syntenic counterpart in zebrafish, which lacks digits, ...
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作者：Keeling, Kim M.
作者单位：University of Alabama System; University of Alabama Birmingham
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作者：Kang, Hyunook; Steigerwald, Ruben; Ullman, Elijah Z.; Epstein, Max; Paladugu, Srinu; Liotta, Dennis C.; Traynelis, Stephen F.; Furukawa, Hiro
作者单位：Cold Spring Harbor Laboratory; Emory University; Emory University; Emory University
摘要：Ion-channel activity reflects a combination of open probability and unitary conductance1. Many channels display subconductance states that modulate signalling strength2,3, yet the structural mechanisms governing conductance levels remain incompletely understood. Here we report that conductance levels are controlled by the bending patterns of pore-forming transmembrane helices in the heterotetrameric neuronal channel GluN1a-2B N-methyl-D-aspartate receptor (NMDAR). Our single-particle electron ...
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作者：Cibulski, Samuel Paulo
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作者：Drew, Liam
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作者：Yanai, Itai
作者单位：New York University
