23期

最新文章

• Navigating the unknown: Nanobubbles and the hidden complexity of aerophilic surfaces AI翻译
  作者：Lu, Junhong
  作者单位：Yantai University
• Fluorescence-lifetime optical electrophysiology in contracting cardiomyocytes AI翻译
  作者：Millar, Euan; Huethorst, Eline; Zickus, Vytautas; Astrauskaite, Giedre; Zhao, Jiuxuan; Taylor, Gregor G.; Bruschini, Claudio; Charbon, Edoardo; Smith, Godfrey L.; Mullenbroich, Caroline; Faccio, Daniele
  作者单位：University of Glasgow; University of Glasgow; Center for Physical Sciences & Technology - Lithuania; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
  摘要：Precise monitoring of cardiac electrophysiology in vitro is crucial to understanding heart function and cardiac disease. However, high-throughput, contact-free methods for directly measuring excitation-contraction coupling remain limited. Here, we introduce a paradigm for quantitative electrophysiological imaging that combines fluorescence lifetime and intensity information to capture dynamic cardiac signals with high fidelity. We show that lifetime measurements are intrinsically decoupled fro...
• In vivo binding by Arabidopsis SPLICING FACTOR 1 shifts 3′ splice-site choice, regulating circadian rhythms and immunity in plants AI翻译
  作者：Agrofoglio, Yamila Carla; Iglesias, Maria Jose; de Leone, Maria Jose; Hernando, Carlos Esteban; Lewinski, Martin; Torres, Sol Belen; Contino, Giuliana; Kohnke, Kim Joelle; Yanovsky, Marcelo Javier; Staiger, Dorothee; Mateos, Julieta Lisa
  作者单位：University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Leloir Institute; University of Bielefeld
  摘要：Alternative splicing expands proteome diversity and enables phenotypic plasticity across eukaryotes. In plants, mutations in spliceosomal components impair development and stress responses, but the molecular mechanisms remain unclear. Here, we define the molecular function of SPLICING FACTOR 1 (AtSF1) in Arabidopsis thaliana using individual-nucleotide resolution UV crosslinking and immunoprecipitation combined with RNA sequencing of sf1 mutants. We identify the in vivo branch point sequences ...
• Discovery of dynamical heterogeneity in a supercooled magnetic monopole fluid AI翻译
  作者：Dasini, Jahnatta; Carroll, Chaia; Murphy, Jack; Dawson, Catherine; Takahashi, Hiroto; Sharma, Sudarshan; Jerzembeck, Fabian; Blundell, Stephen J.; Luke, Graeme M.; Davis, J. C. Seamus; Ward, Jonathan
  作者单位：University College Cork; University of Oxford; McMaster University; Max Planck Society
  摘要：Dynamical heterogeneity, in which transitory local fluctuations occur in the conformation and dynamics of constituent particles, is widely hypothesized to be essential to the evolution of supercooled liquids into the structural glass state. Yet its microscopic spatiotemporal phenomenology is challenging to detect directly in molecular glass forming liquids. Because recent theoretical advances predict that corresponding dynamical heterogeneity could occur in supercooled magnetic monopole fluids...
• Canadian wildfires are losing their climate-cooling influence from postfire snow albedo AI翻译
  作者：van Gerrevink, Max J.; Gonsamo, Alemu; Rogers, Brendan M.; Potter, Stefano; Zhong, Zilong; Veraverbeke, Sander
  作者单位：Vrije Universiteit Amsterdam; Wageningen University & Research; McMaster University; University of East Anglia
  摘要：The 2023 Canadian fire season was record-breaking in terms of burned area and carbon emissions. Here, we present estimates of the regional climate-cooling effect from postfire surface albedo changes, which have historically partially offset the warming influence of fire emissions by wildfires. We estimate that the 2023 fires generated a time-integrated climate cooling of -3.41 W m-2 of burned area (95% CI: -4.39 to -2.43) over a 70-y period. We show that the climate-cooling impact has weakened...
• Memory, chaos, and noise in ecological forecasting AI翻译
  作者：Munch, Stephan B.; Rogers, Tanya L.
  作者单位：National Oceanic Atmospheric Admin (NOAA) - USA; University of California System; University of California Santa Cruz
  摘要：Ecological populations fluctuate for reasons that are often ascribed-separately-to historical legacies, intrinsic nonlinear dynamics, or stochastic noise. Yet these forces rarely act in isolation. We assembled a global database of 302 abundance time series spanning birds, mammals, fishes, insects, and plankton to ask how memory, nonlinearity, and dynamical stability interact to shape predictability. We used empirical dynamic modeling to estimate the memory length and classified time series sta...
• Quantum coherent Chladni-like resonance: Programming ions as matter waves for subpicosecond conduction AI翻译
  作者：Sezen, Yaren; Ciftci, Niyazi Okan; Sarsil, Mehmet Ali; Czelej, Kamil; Ergen, Onur
  作者单位：Istanbul Technical University; Istanbul Technical University; Warsaw University of Technology; Consiglio Nazionale delle Ricerche (CNR); Istituto di Nanotecnologia (NANOTEC-CNR)
  摘要：Achieving coherent control of ionic transport in solids, analogous to electron waveguides, remains a fundamental challenge, as ionic motion is typically limited by slow, stochastic hopping. Here, we demonstrate that a two-dimensional electrochemical cell (borophene/h-BN/graphene) possesses a collective ionic eigenmode, which, when resonantly excited by a critical-frequency electrical pulse (10 kHz), transforms ionic conduction from diffusive drift into a coherent, ballistic wave. Time-resolved...
• Polyphosphate synthesis is essential for phosphate and ATP homeostasis during nutrient upshift AI翻译
  作者：White, Maria L.; Mortier, Julien; Granqvist, Lova; Omnus, Deike J.; Louski, Max; Crang, Nick; Aldikacti, Berent; Migeot, Valerie; Chien, Peter; Hennequart, Marc; Hallez, Regis; Jonas, Kristina
  作者单位：Stockholm University; Royal Institute of Technology; University of Massachusetts System; University of Massachusetts Amherst; University of Namur; University of Namur; University of Namur; Flanders Institute for Biotechnology (VIB); Royal Institute of Technology
  摘要：Inorganic polyphosphate (polyP) is a ubiquitous molecule found across all domains of life. Although implicated in diverse cellular processes, including phosphate storage, stress responses, and pathogenicity, loss of polyP synthesis typically causes only mild growth defects. Here, we demonstrate an essential physiological role for polyP synthesis during recovery from phosphate starvation, when cells transition from phosphate-limited to phosphate-replete conditions. Using a comprehensive transpo...
• TadA-mediated A-to-I mRNA editing rewires redox metabolism to promote dominance of epidemic Klebsiella pneumoniae clones AI翻译
  作者：Wu, Xingyu; Jin, Longyang; Wang, Qi; Wang, Ruobing; Li, Bowen; Jiang, Chongyang; Song, Kaiwen; Chen, Long; Yin, Guankun; Chen, Fengning; Liu, Xiaoyun; Wang, Hui
  作者单位：Peking University; Peking University; Peking University
  摘要：Dominant carbapenem-resistant Klebsiella pneumoniae (CRKP) clones have markedly intensified the burden of invasive infections while severely restricting treatment options. Although genomic determinants of these high-risk lineages are well characterized, adaptive regulatory mechanisms beyond fixed DNA variation remain poorly understood. Here we systematically map the adenosine-to-inosine (A-to-I) mRNA editing landscape in CRKP and reveal that clinically dominant lineages possess a constrained a...
• Crotonylation impedes c-Myc oncogenic activity AI翻译
  作者：Wallbillich, Nicholas J.; Liao, Peng; Srivastava, Rashmi; Fan, Jia; Zeng, Shelya X.; Lu, Hua
  作者单位：Tulane University; Tulane University; Tulane University Hospital; University of Michigan System; University of Michigan; Ochsner Health System
  摘要：c-Myc, an important oncoprotein, is highly regulated via posttranslational modifications. Herein, we report c-Myc crotonylation, an acylation stemming from the short-chain fatty acid crotonate. By biochemical analyses and high-resolution mass spectrometry sequencing, we showed that c-Myc is crotonylated at several lysine residues, spanning its middle to C termini. Mutation of these crotonylation sites conferred cells with a significant proliferative advantage with two key residues at K289 and ...