23期

最新文章

• Host methylglyoxal activates the Listeria virulence program, allowing bacteria to evade inflammatory phagocytes by cell-to-cell spread AI翻译
  作者：Anaya-Sanchez, Andrea; Ragunathan, Preethi T.; Hung, Angela; Van Alst, Andrew J.; Lobanovska, Mariya; Stanley, Sarah A.; Portnoy, Daniel A.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Roche Holding; Roche Holding USA; Genentech
  摘要：Methylglyoxal is a reactive aldehyde produced by macrophages as part of their antimicrobial innate immune arsenal. Our prior work showed that Listeria monocytogenes relies on glyoxalase A (GloA) and bacterial glutathione to detoxify methylglyoxal and that loss of GloA severely impairs bacterial virulence in mice and results in a 100 to 1,000 increase in bacterial mutation frequency. Glutathione is required for both methylglyoxal detoxification and for allosteric activation of the master virule...
• With qualitative research, the risks of data sharing can outweigh the rewards AI翻译
  作者：Calarco, Jessica
  作者单位：University of Wisconsin System; University of Wisconsin Madison
• Animals have expanded the evolutionary legacy of unicellular ancestors in blood cells AI翻译
  作者：Nagahata, Yosuke; Nishimura, Yuji; Kaitani, Ryota; Leong, Jason Cheok Kuan; Oda-Ishii, Izumi; Kohtsuka, Hisanori; Abe, Shinya; Ishida, Tasuku; Carmona-Rivas, Marina; Najle, Sebastian R.; Casacuberta, Elena; Ikuta, Koichi; Miura, Toru; Ogasawara, Michio; Irie, Naoki; Satou, Yutaka; Ruiz-Trillo, Inaki; Kawamoto, Hiroshi
  作者单位：Kyoto University; Consejo Superior de Investigaciones Cientificas (CSIC); Pompeu Fabra University; CSIC-UPF - Institut de Biologia Evolutiva (IBE); Japan Society for the Promotion of Science; Graduate University for Advanced Studies - Japan; Kyoto University; University of Tokyo; Kyoto University; Institute of Science Tokyo; Universitat Internacional de Catalunya (UIC); Chiba University; ICREA
  摘要：Blood cells are common and unique to animals, enabling them to address critical challenges of defense and transport. Thus, their evolution represents a defining innovation in metazoan multicellular life. However, their evolutionary trajectory about how blood cells emerged and diversified throughout animal history remains unclear. Here, we present a combination of bioinformatics and functional data that demonstrate that the metazoan blood cell program most likely originated through the repurpos...
• Nondisclosure agreements and externalities from silence AI翻译
  作者：Sockin, Jason; Sojourner, Aaron; Starr, Evan
  作者单位：Cornell University; W.E. Upjohn Institute for Employment Research; University System of Maryland; University of Maryland College Park
  摘要：How do contractual restrictions on worker voice affect information flows about employers? We develop a framework in which the legal risk from violating a nondisclosure agreement (NDA) reduces the willingness of workers to share negative information, making it more difficult for high-road employers to differentiate themselves to workers. Empirical support for these ideas comes from studying the relationship between NDA use and the content of Glassdoor reviews after three states prohibited emplo...
• DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity AI翻译
  作者：Ernst, Larissa; Gatgens, Cornelia; Rackow, Bente; Pozhydaieva, Nadiia; Gaaloul, Elyes; Kruger, Aileen; Seiffarth, Johannes; Bund, Michelle; Joisten-Rosenthal, Vivien; Kohlheyer, Dietrich; Usadel, Bjorn; Harms, Alexander; Hofer, Katharina; Frunzke, Julia
  作者单位：Helmholtz Association; Julich Research Centre; Heinrich Heine University Dusseldorf; Max Planck Society; Philipps University Marburg; Heinrich Heine University Dusseldorf; Helmholtz Association; Julich Research Centre; Swiss Federal Institutes of Technology Domain; ETH Zurich; Philipps University Marburg
  摘要：Bacteria deploy diverse antiphage defense systems, including small bioactive molecules providing protection at the multicellular level. DNA-intercalating anthracyclines, such as daunorubicin, exhibit broad antiphage activity, but the underlying mechanism has remained elusive. Here, we systematically screened the Escherichia coli BASEL phage collection to elucidate the mode of action of DNA-intercalating antiphage molecules. We identified taxonomically distinct clusters of susceptible viral gro...
• Canonical and variant PRC1 functionally converge on PRC2 targets to regulate transcriptional programs during mouse limb development AI翻译
  作者：Gentile, Claudia; Paul, Rachel; Guerard-Millet, Fanny; Villiard, Gabriel; Poitras, Christian; Mayran, Alexandre; Robert, Francois; Kmita, Marie
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Institut de Recherche Clinique de Montreal (IRCM); Universite de Montreal; McGill University; Universite de Montreal; Universite de Montreal; Institut de Recherche Clinique de Montreal (IRCM); Swiss School of Public Health (SSPH+)
  摘要：The developing limb is a classical model system for studying genetic aspects of pattern formation and mechanisms underlying tissue differentiation. The transition from early to differentiated cell fates during limb bud development requires the precise spatial and temporal regulation of gene activation and silencing programs. However, how transcriptional silencing of early genes is achieved remains poorly understood. Here, we investigate the role of the Polycomb Repressive Complexes (PRC1 and P...
• Aerobic soil bacteria adapt to hypoxia by hybridizing fermentation with carbon storage AI翻译
  作者：Gillett, David L.; Koralegedara, Thilini; Hutchinson, Tess F.; Nguyen-Dinh, Thanh; Watts, Thomas D.; Solari, Jessica; Mudaliyar, Manasi; Jowsey, William J.; Athukorala, Nadeesha; Wong, Wei Wen; Locop, Jake U. S.; Hall, Ning; Jimenez, Luis; Hanchapola, Iresha; Lee, Han-Chung; Tanuwidjaya, Erwin; Steele, Joel R.; Schittenhelm, Ralf B.; Barlow, Christopher K.; Grinter, Rhys; Cook, Gregory M.; McNeil, Matthew B.; Ghosal, Debnath; Leung, Pok Man; Cook, Perran L. M.; Greening, Chris
  作者单位：Monash University; Monash University; Monash University; University of Melbourne; University of Otago; Monash University; Queensland University of Technology (QUT); University of Melbourne
  摘要：In soil ecosystems, aerobic bacteria survive oxygen deprivation (hypoxia) by entering nonreplicative persistent states. In contrast to the well-studied metabolism of obligate and facultative anaerobes, little is known about how obligately aerobic bacteria adapt their metabolism to stay viable during hypoxia. The model obligate aerobe Mycobacterium smegmatis maintains redox homeostasis during hypoxia by mediating fermentative hydrogen production. However, the fate of organic carbon during ferme...
• From bedside to bench: A multimodal approach uncovering the molecular basis of the MYBPC1-linked Myotrem myopathy AI翻译
  作者：Iyer, Aishwarya S.; Wright, Nathan T.; Cook, Mary E.; Takagi, Yasuharu; Johnson, Bruce A.; Biancalana, Valerie; Massier, Marie; Spodenkiewicz, Marta; Poirsier, Celine; Vallecillo, Brice; Constant Boyer, Francois; Pineau, Charlotte; Hensley, Lindsey; Sellers, James R.; Varney, Kristen M.; Weber, David J.; Kontrogianni-Konstantopoulos, Aikaterini
  作者单位：University System of Maryland; University of Maryland Baltimore; James Madison University; University System of Maryland; University of Maryland Baltimore; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); City University of New York (CUNY) System; CHU Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); CHU de Reims; Universite de Reims Champagne-Ardenne; CHU de Reims; Universite de Reims Champagne-Ardenne; CHU de Reims; Universite de Reims Champagne-Ardenne
  摘要：Myotrem is an untreatable, early-onset, congenital myopathy characterized by hypotonia, muscle weakness, skeletal deformities, dysmorphia, respiratory insufficiency, and myogenic tremor (V. Shashi et al., Hum Mutat, 2019 and J. Stavusis et al., Ann. Neurol., 2019). It is associated with dominant variants in the pivotal M-domain of slow-skeletal Myosin Binding Protein-C (sMyBP-C) that modulates the dynamic binding to myosin and actin filaments and thereby crossbridge formation and kinetics. Her...
• How nature discovers rare Turing islands: Exploration by common limit cycles AI翻译
  作者：Kim, Seyoon; Matas-Gil, Antonio; Endres, Robert G.
  作者单位：Imperial College London; Imperial College London; University of London; University College London; University of London; University College London
  摘要：Turing patterns are a cornerstone of biological self-organization, yet their emergence typically requires finely tuned parameters occupying narrow regions of high-dimensional space. This poses a fundamental challenge: how can evolving biological systems reliably find and exploit such rare conditions? In this work, we propose that common biochemical limit cycles, such as those arising from genetic feedback loops, can act as natural explorers of Turing space. By coupling a reaction-diffusion sys...
• Chemical modulation of chloroplast de- and redifferentiation reveals a role for the SAL1-PAP retrograde pathway in facilitating plastid transitions AI翻译
  作者：Perez-Colao, Pablo; Cruces, Jacobo; Perez-Rodriguez, Santiago; Koprivova, Anna; Kopriva, Stanislav; Skirycz, Aleksandra; Lozano-Juste, Jorge; Rodriguez-Concepcion, Manuel
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universitat Politecnica de Valencia; CSIC-UPV - Instituto de Biologia Molecular y Celular de Plantas (IBMCP); University of Cologne; Michigan State University
  摘要：Plastids are dynamic organelles that remodel their composition, ultrastructure, and function according to developmental and environmental demands. The synthetic molecule X57 induces the conversion of leaf chloroplasts into tocopherol-rich plastids lacking thylakoids and containing proliferating plastoglobules. Removal of X57 triggers chloroplast redifferentiation, enabling precise spatial-temporal dissection of these transitions. X57 directly binds and inhibits the phosphatase SAL1, causing ac...