23期

最新文章

• A 3'UTR-derived small RNA modulates the life cycle of the cholera toxin-encoding filamentous phage, CTXφ AI翻译
  作者：Lippegaus, Anne; Haycocks, James R. J.; O'Driscoll, Eoghan; Sprenger, Marcel; Thriene, Kerstin; Jung, Elke-Martina; Siemers, Malte; Krautwurst, Sebastian; Grainger, David C.; Papenfort, Kai
  作者单位：Friedrich Schiller University of Jena; University of Birmingham; Friedrich Schiller University of Jena
  摘要：Bacteriophages (phages) are well known to be one of the major driving forces in bacterial evolution. This also applies to virulent microorganisms, such as the major human pathogen Vibrio cholerae, whose pathogenic potential and epidemic proliferation largely depends on the interaction with environmental phages. Specifically, integration of the CTX phi phage genome into the first chromosome of V. cholerae also introduced the ctxAB genes, encoding the primary toxin responsible for the severe acu...
• 15-PGDH inhibition promotes muscle repair and strength recovery during GLP-1 receptor agonist-induced weight loss AI翻译
  作者：Nalbandian, Minas; Lone, Jameel; Le Moal, Emmeran; Kim, Ireh; Jeuris, Kaitlin; Li, Yutong Kelly; Kraft, Peggy; Zhao, Meng; Koleckar, Kassie; Zhang, Zeyuan; Svensson, Katrin J.; Blau, Helen M.
  作者单位：Stanford University; Stanford Medicine; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; University of California System; University of California Davis; Stanford University; Stanford Medicine
  摘要：Glucagon-like peptide-1 receptor agonists, including long-acting semaglutide, are transformative anti-obesity therapies. However, emerging evidence indicates that weight loss may come at the expense of skeletal muscle mass, a tissue essential for mobility, metabolic regulation, and overall health. Here, we show that inhibition of the gerozyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme that increases with injury and aging, improves muscle repair and streng...
• Type I hair cells of striolar and central zones in vestibular organs are essential for head stability and postural control AI翻译
  作者：Ono, Kazuya; Lee, Hyun Jae; Chang, Hui Ho Vanessa; Verdone, Brandie Morris; Wafa, Talah; Ji, Youngrae; Huang, Austin; Fitzgerald, Tracy; Cullen, Kathleen E.; Wu, Doris K.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD); Johns Hopkins University; Johns Hopkins Medicine; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD); University of Osaka; Korea Brain Research Institute (KBRI); Stanford University
  摘要：The vestibular system of the inner ear provides head motion and orientation information required for maintaining balance and spatial orientation. Each of the five vestibular sensory organs contains type I and type II hair cells (HCs). Type I HCs are particularly notable for their evolutionary adaptability and unique calyceal synapses, in which the vestibular afferent nerve ending envelopes the HC body. In vitro studies indicate that calyceal synapses can transduce signals from HCs to afferents...
• Covalent inhibitors of human papillomavirus type 16 E6 protein restore p53 function and suppress growth of HPV-driven tumors in vivo AI翻译
  作者：Rietz, Anne; Kumari, Lokesh; Koirala, Ankeeta; Pelletier, Stephane; Lu, Zhijian; Androphy, Elliot J.
  作者单位：Indiana University System; Indiana University Indianapolis; Indiana University System; Indiana University Indianapolis
  摘要：High-risk human papillomaviruses (HPVs) promote malignant progression through sustained expression of the viral oncoprotein E6, which drives degradation of the tumor suppressor p53 and creates an oncogenic dependency in HPV-positive cancers. Here, we identify a genotype-defined therapeutic vulnerability by selectively and irreversibly inactivating HPV-16 E6 through covalent targeting a cysteine proximal to its E6AP-binding interface. Pharmacologic inhibition of E6 restored p53 protein stabilit...
• Mean field game model of the impact of reductions in support on faculty research activity AI翻译
  作者：Brown, Robert A.
  作者单位：Boston University
  摘要：Every research university has a distribution of faculty research activity that is fueled by the external support from government, industry, and philanthropy. The large decreases in federal support proposed in 2025 by the Administration would dramatically alter the distribution of faculty research activity. Mean field game (MFG) theory is used to model federal support of faculty research assuming that each researcher seeks to maximize their funding according to a specified utility function. Mod...
• Impacts of future sea level change on Greenland from community knowledge, coastal mapping, and glacial isostatic adjustment models AI翻译
  作者：Tinto, Kirsty J.; Austermann, Jacqueline; Bell, Robin E.; Blockley, David; Brayton, Casey E.; Krawczyk, Diana; Lewright, Lauren; Lloyd, Andrew J.; Nitsche, Frank O.; Paxman, Guy J. G.; Porter, David F.; Sorensen, Aqqaluk; Turrin, Margie; Zinglersen, Karl
  作者单位：Columbia University; Columbia University; Columbia University; Greenland Institute of Natural Resources; Greenland Institute of Natural Resources; Durham University
  摘要：Making predictions of global change relevant to individual communities is a critical challenge, especially where local impacts diverge from global predictions. While sea level is rising globally, in Greenland, sea level is predicted to fall over the coming century due to land rebound and sea surface lowering, consequences of glacial isostatic adjustment from both past and future ice loss. Here we present results of a US and Greenland scientific partnership, working with the community of Aasiaa...
• Reply to Lu: Aerophilic interfaces across scales AI翻译
  作者：Vandereydt, Bert J. C.; Nath, Saurabh; Varanasi, Kripa K.
  作者单位：Massachusetts Institute of Technology (MIT); University of Pennsylvania
• Social cues drive the evolution of plastic pathogen virulence in spatially and temporally variable environments AI翻译
  作者：Kumata, Ryuichi; Lion, Sebastien; Westra, Edze R.; Gandon, Sylvain
  作者单位：Universite Paul-Valery; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Universite PSL; Institut Agro; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro Montpellier; University of Exeter
  摘要：Host-pathogen interactions are often characterized by spatial and temporal fluctuations in host density. Such variability may promote the evolution of phenotypic plasticity in pathogen virulence. However, it remains unclear how pathogens can reliably detect changes in host density. Here we show that some pathogens may exploit social cues, such as the presence of infected hosts, to gain indirect information about transmission opportunities when the density of susceptible hosts fluctuates. Our a...
• GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain AI翻译
  作者：Liu, Minjun; Hung, Madison; Kozlov, Ellen; Hung, Megan; Colaco-Gaspar, Mariana; Roy, Shristi; Tu, Yiping; Magaki, Shino D.; Williams, Christopher K.; Andaloussi Mae, Maarja; Johnson, Erik C. B.; Siegel, Robert W.; Konrad, Robert J.; Ploug, Michael; Betsholtz, Christer; Beigneux, Anne P.; He, Liqun; Fong, Loren G.; Young, Stephen G.
  作者单位：University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; Uppsala University; Emory University; Eli Lilly; Lilly Research Laboratories; University of Copenhagen; Rigshospitalet; Copenhagen University Hospital; University of Copenhagen; Karolinska Institutet; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center
  摘要：In peripheral tissues, lipoprotein lipase (LPL) is secreted by parenchymal cells (adipocytes, myocytes) into the interstitial spaces, where it is captured by GPIHBP1 (a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells) and escorted to the luminal surface of capillaries. The LPL inside capillaries hydrolyzes glycerolipids in the plasma lipoproteins, releasing fatty acids for parenchymal cells. In the central nervous system, LPL is synthesized by multiple cell types [...
• HLA micropolymorphisms confine neoantigen conformational adaptability and guide T cell receptor selectivity AI翻译
  作者：Ma, Jiaqi; Ayres, Cory M.; Brambley, Chad A.; Eldaly, Bassant; Perera, W. W. J. Gihan; Lazar, James A.; Kovrigin, Evgenii L.; Chandran, Smita S.; Klebanoff, Christopher A.; Baker, Brian M.
  作者单位：University of Notre Dame; University of Notre Dame; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; Westlake University
  摘要：T cell receptor (TCR) restriction by highly polymorphic major histocompatibility complex (MHC) proteins is a foundation of cellular immunity. Although the effects of MHC polymorphisms on peptide binding and selection are well established, how micropolymorphisms within MHC supertypes impact immune recognition is poorly understood. Here, we identified a mechanism through which the micropolymorphisms in two closely related HLA-A3 superfamily members govern TCR specificity. We previously showed th...