23期

最新文章

• Polyphosphate affects the growth and methanogenesis of deep-sea methanogenic archaea AI翻译
  作者：Zheng, Rikuan; Wang, Chong; Zheng, Yuxin; Cao, Lei; Liu, Kaitao; Li, Jie; Sun, Chaomin
  作者单位：Chinese Academy of Sciences; Institute of Oceanology, CAS; Chinese Academy of Sciences; Institute of Oceanology, CAS; Central China Normal University; Chinese Academy of Sciences; Institute of Microbiology, CAS
  摘要：Microorganisms employ inorganic polyphosphate (polyP) as an ancient strategy for energy and phosphate storage, yet its physiological roles in methanogenic archaea remain largely unexplored. Here, we report that polyP metabolism is coupled to growth and methanogenesis in Methanolobus sp. ZRKC1, a representative of eight methanogenic archaea isolated from deep-sea cold seep sediments. Through combined genetic, biochemical, and physiological analyses, we find that PPK1 mediates polyP synthesis in...
• Reply to Janssens and Mech: The possibility of natural wolf dispersal to Stora Karlso AI翻译
  作者：Girdland-Flink, Linus; Bergstrom, Anders; Stora, Jan; Ersmark, Erik; Apel, Jan; Krzewinska, Maja; Dalen, Love; Gotherstrom, Anders; Skoglund, Pontus
  作者单位：University of Aberdeen; Liverpool John Moores University; University of East Anglia; Francis Crick Institute; Stockholm University; Swedish Museum of Natural History; Stockholm University; Swedish Museum of Natural History
• Did Stora Karlso wolves reach the island naturally or by boat? AI翻译
  作者：Janssens, Luc A.; Mech, L. David
  作者单位：Ghent University; United States Department of the Interior; United States Geological Survey
• Subsarcomeric regulation of thin and thick filaments in skeletal muscle myofibrils AI翻译
  作者：Sliogeryte, Kristina; Fusi, Luca
  作者单位：University of London; King's College London; University of London; King's College London
  摘要：Muscle contraction relies on the coordinated activation of myosin motors from a folded-OFF state on the thick filament surface and their actin tracks on the thin filaments in response to calcium. Thick filaments contain distinct regulatory zones defined by the presence of myosin-binding protein C (MyBP-C) and titin super-repeats, but the control of myosin OFF/ON states within these zones has not been directly resolved. Here, we do so by fluorescence polarization microscopy (FPM) in myofibrils ...
• The politicization of academic collaborations threatens to harm international science AI翻译
  作者：Cadotte, Marc W.
  作者单位：University of Toronto; University Toronto Scarborough
• Cryo-EM structures of Měnglà virus GP reveal combined Ebola- and Marburg-like epitope masking strategies for antibody evasion AI翻译
  作者：Wang, Longyu; Zou, Binqian; Liu, Banghui; Ma, Yong; Xue, Lu; Habib, Gul; Yang, Xinglou; Chen, Xinwen; Chen, Jiantao; Zhao, Jincun; Zhang, Ying; Yang, Zifeng; He, Jun; Xiong, Xiaoli
  作者单位：Guangzhou Medical University; Guangzhou Laboratory; State Key Laboratory of Respiratory Disease; Guangzhou Medical University; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; ShanghaiTech University; Sun Yat Sen University
  摘要：Ebola virus (EBOV) and Marburg virus (MARV) are highly lethal filoviruses that cause severe hemorrhagic fever in humans. A recently identified bat-borne filovirus, M & ecaron;ngl & agrave; virus (MLAV), uses the same NPC1 receptor as EBOV and MARV, raising concerns about its potential cross-species transmission. Here, we report cryo-EM structures of the MLAV surface glycoprotein (GP) in its unbound form and in complex with the MARV-neutralizing antibody MR191. MLAV GP exhibits distinctive stru...
• APOBEC2 deficiency disrupts hematopoietic lineage commitment, resulting in emergence of dual identity lymphocytes in mice and humans AI翻译
  作者：Amro, Elias Moris; Gkougkousis, Christos; Seebass, Joachim Guido; Telioglu, Irem; Bakr, Ali; Lorenzo, Jose Paulo; Abolhassani, Hassan; Altenhofen, Jan; Berntson, Lillemor; Ruf, Sandra; Hammarstrom, Lennart; Pan-Hammarstrom, Qiang; Imbusch, Charles D.; Papavasiliou, F. Nina
  作者单位：Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Johannes Gutenberg University of Mainz; Helmholtz Association; German Cancer Research Center (DKFZ); Johannes Gutenberg University of Mainz; Helmholtz Association; German Cancer Research Center (DKFZ); Karolinska Institutet; Uppsala University; Helmholtz Association; German Cancer Research Center (DKFZ)
  摘要：APOBEC2 is a well-conserved member of the AID/APOBEC family of cytidine deaminases. Most members of the family catalyze the conversion of cytosine to uracil either in DNA or RNA, thereby acting as DNA mutators and/or RNA editors. APOBEC2 is the only family member that appears to be catalytically inactive. Instead, its ability to bind, but not deaminate DNA, has been co-opted into a transcription-factor-like functionality. APOBEC2 is highly expressed in skeletal muscle, where it functions to pr...
• Partial reconstitution of the prophenoloxidase activation system in Anopheles gambiae AI翻译
  作者：Hou, Chunxiang; Wang, Yang; Jiang, Haobo
  作者单位：Oklahoma State University System; Oklahoma State University - Stillwater
  摘要：Melanization is a central insect immune response to wounding and microbial invasion. It is mediated by a system of serine proteases and their homologs, mostly members of the CLIP subfamily, and leads to prophenoloxidase (proPO) activation and PO-mediated production of cytotoxic compounds and melanin polymers that kill and sequester invading pathogens. In mosquitoes, melanotic encapsulation provides an effective defense against malaria parasites, yet the composition and organization of the unde...
• Simultaneous transformations of view and place coding across reference frames in the macaque brain AI翻译
  作者：Huang, Yan; Liu, Anran; Xu, Xiao; Du, Kechen; Mao, Dun
  作者单位：Chinese Academy of Sciences; Center for Excellence in Brain Science and Intelligence Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; ShanghaiTech University; Lin Gang Laboratory
  摘要：Vision enables primates to remotely map their environment using eye movements rather than physical locomotion. While view-related spatial coding is prevalent in the primate hippocampus, its origin and precise relationship to standard place coding remain largely unknown. Leveraging untethered neural recording, motion capture, and wireless eye tracking, we examined view and place coding along the parietal-retrosplenial-hippocampal pathway in macaque monkeys freely exploring an open arena. We ide...
• Polyunsaturated fatty acid-derived lipid mediator patterns determine viral pneumonia severity and risk for critical COVID-19 AI翻译
  作者：Papadaki, Maria; Pavlos, Eleftherios; Dubourdeau, Marc; Bailif, Vincent; Badirou, Kamal; Gely, Clemence A.; Galani, Ioanna-Evdokia; Papelis, Dimitris; Kamperi, Natalia; Triantafyllia, Vasiliki; Siouti, Eleni; Salagianni, Maria; Manioudaki, Maria; Paschalidis, Nikolaos; Vatsellas, Giannis; Koukaki, Evangelia; Rapti, Vasiliki; Thanos, Dimitris; Rovina, Nikoletta; Poulakou, Garyfallia; Cobat, Aurelie; Casanova, Jean-Laurent; Tamvakopoulos, Constantin; Andreakos, Evangelos
  作者单位：Academy of Athens; University of Crete; Academy of Athens; Academy of Athens; Academy of Athens; National & Kapodistrian University of Athens; National & Kapodistrian University of Athens; Rockefeller University; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Howard Hughes Medical Institute
  摘要：Severe respiratory infections such as COVID-19 are characterized by excessive inflammation leading to the development of pneumonia and acute respiratory distress syndrome. Bioactive lipid mediators (LMs) derived from omega 6 and omega 3 polyunsaturated fatty acids are central to the regulation of inflammation, controlling both its initiation and resolution. Still, their role in viral infections remains underexplored. By employing a holistic approach involving the analysis of white blood cell t...