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作者：Guikema, Seth; Pagan-Cajigas, Zaira; Fant, Charles; Boehlert, Brent; Maier, C. X.; Emanuel, Kerry; Hartin, Corinne; Sarofim, Marcus C.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Industrial Economics, Incorporated; United States Environmental Protection Agency
摘要：This research investigates the projected risks of future climate trends on tropical cyclone- induced power outages in the Gulf and Atlantic coast of the United States, focusing on the disproportionate impacts on vulnerable populations and the economic burdens associated with such events. Our methodology integrates four well- documented models to estimate changes in power outage rates, sociodemographic inequities, and economic costs due to tropical cyclone projections. Synthetic tropical cyclon...
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作者：Guzman, Asja; Kawase, Tatsuya; Devanny, Alexander J.; Efe, Gizem; Navaridas, Raul; Yu, Karen; Regunath, Kausik; Mercer, Iris G.; Avard, Rachel C.; de Queiroz, Rafaela Muniz; Rustgi, Anil K.; Kaufman, Laura J.; Prives, Carol
作者单位：Columbia University; Astellas Pharmaceuticals; Columbia University; Columbia University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; Columbia University
摘要：Certain TP53 mutations can confer neomorphic gain of function (GOF) activities to the p53 protein that affect cancer progression. Yet the concept of mutant p53 GOF has been challenged. Here, using various strategies to alter the status of mutant versions of p53 in different cell lines, we demonstrate that mutant p53 stimulates cancer cell invasion in three-dimensional environments. Mechanistically, mutant p53 enhances RhoA/ROCK-dependent cell contractility and cell-mediated extracellular matri...
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作者：Kitto, Elizabeth S.; Beydoun, Safa; Leiser, Scott F.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
摘要：In multicellular organisms, sensory perception affects many aspects of behavior and physiology. Perception of environmental stressors like food scarcity often leads to physiological changes that promote survival and slow aging. However, recent work shows that perception of attractive food smells can block the health benefits of dietary restriction in multiple model organisms. While it is known that sensory perception and cell non-autonomous signaling can modulate health and longevity, our know...
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作者：Moriguchi, Yusuke; Watanabe, Ryoichi; Sakata, Chifumi; Zeleznikow-Johnston, Ariel; Wang, Jue; Saji, Noburo; Tsuchiya, Naotsugu
作者单位：Kyoto University; Japan Society for the Promotion of Science; Monash University; Monash University; Waseda University; National Institute of Information & Communications Technology (NICT) - Japan
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作者：You, Jueng Soo; Pierce, Steve; Liang, Gangning; Jones, Peter A.
作者单位：Konkuk University; Konkuk University Medical Center; Van Andel Institute; University of Southern California
摘要：The origins of CpG islands (CGIs) are not known. They are relatively short GC-rich regions of DNA with a higher-than-expected occurrence of CpG dinucleotides compared to most of the genome. They constitute less than 1% of the human genome but harbor approximately 40% of all transcription start sites (TSSs). CGIs are usually modulated by histone modifications in somatic cells or, in a minority of cases, permanently silenced by CpG methylation. Those that do not have TSSs are called orphan CGIs....
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作者：Alam, Ornob; Gutaker, Rafal; Surya, Niketh; Castillo, Cristina; Fuller, Dorian; Guedes, Jade d'Alpoim; Purugganan, Michael
作者单位：New York University; Royal Botanic Gardens, Kew; University of London; University College London; University of Washington; University of Washington Seattle; New York University; New York University Abu Dhabi; New York University
摘要：Rice (Oryza sativa) was first domesticated beginning similar to 9,000 y ago in China as the japonica variety group/subspecies. Using genomic data from 456 japonica landraces, including data for 47 herbarium specimens collected over the last 167 y, we reconstruct how japonica rice moved from its center of origin to other parts of Asia beginning similar to 4,000 to 5,500 y ago. We observe an enrichment of pathogen resistance loci in selective sweeps associated with distinct geographic population...
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作者：Hatfull, Graham F.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：A renewed interest in bacteriophages has emerged from the explosive discovery of the complex pan-immune bacterial defense system and a revival of the therapeutic potential of phages in the age of widespread antimicrobial resistance to antibiotics. However, the road ahead is daunting because of the huge genetic diversity of phages and the vast numbers of genes of unknown function. A fully integrated approach that includes curiosity-driven exploration of phage biology, the development of integra...
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作者：Charara, Shadi; Choy, Jonathan; Cauwenberghs, Kalyani; Vijayakumar, Pawel; Ng, Renny; Kim, Keun - Young; Weng, Shih - Che; Akbari, Omar S.; Ellisman, Mark H.; Rifkin, Scott A.; Su, Chih - Ying
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Wayne State University; Harvard University; National Taiwan University
摘要：Hematophagous mosquitoes use CO2 as a key arousal signal that gates behavioral responses to host- derived cues. In Aeries aegypti, CO2 is detected by olfactory receptor neurons (ORNs) housed in the sensory hairs (sensilla) on the maxillary palp. While the molecular mechanism and behavioral significance of CO2 sensing have been well studied in mosquitoes, the nanoscale three- dimensional structures of their CO2- sensing ORNs and associated cells have remained unclear. Using serial block- face s...
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作者：Li, Tang; Falch, Ken Vidar; Garrevoet, Jan; Dubrovinsky, Leonid; Lyubomirskiy, Mikhail
作者单位：Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); University of Bayreuth; Lund University
摘要：We present an approach to nanoscale-resolution high-sensitivity imaging of internal material structure under in situ/operando conditions for virtually any sample environment. When bulky or heavy sample environment is required state-of-the-art X-ray imaging techniques, such as scanning and full-field microscopy or holography fail to deliver high-resolution imaging capabilities due to either i) extremely small optics' working distance for magnification-based methods or ii) the inability to preci...
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作者：Martin, Patrick; Vasilyev, Gleb; Zussman, Eyal; Yarin, Alexander L.
作者单位：Technion Israel Institute of Technology; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
摘要：A theory of solutions of charged polyelectrolyte (PE) macromolecules, treating them as electric dipoles, is proposed. In a thin thread of PE solution sustained between two disks-whether wettable or nonwettable-these dipoles are reoriented by an axial electric field, aligning themselves with the field direction. This alignment causes significant axial elastic stresses and affects capillary self-thinning dynamics of the thread, slowing the process and potentially arresting it entirely, and even ...
