43期

最新文章

• Parallel shifts in differential gene expression reveal convergent miniaturization in fishes AI翻译
  作者：Troyer, Emily M.; White, William T.; Betancur-R, Ricardo; Arcila, Dahiana
  作者单位：University of Oklahoma System; University of Oklahoma - Norman; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Commonwealth Scientific & Industrial Research Organisation (CSIRO); Australian National Fish Collection; University of California System; University of California San Diego; Scripps Institution of Oceanography
  摘要：Body size variation in vertebrates is a complex polygenic trait, tightly correlated with numerous aspects of a species' biology, ecology, and physiology. Miniaturization, the extreme reduction of adult body size, is a common phenomenon across the Tree of Life, yet the mechanisms underlying this process are poorly understood. Here, we investigate the molecular basis of body size evolution in goby fishes, a clade encompassing some of the smallest vertebrates on Earth. We generate a genome-wide p...
• A Bayesian perspective on single-shot laser characterization AI翻译
  作者：Esslinger, J.; Weisse, N.; Eberle, C.; Schroder, J.; Howard, S.; Norreys, P.; Karsch, S.; Dopp, A.
  作者单位：University of Munich; University of Oxford
  摘要：We introduce a Bayesian framework for measuring spatiotemporal couplings in ultraintense lasers that reconceptualizes what constitutes a single-shot measurement. Moving beyond traditional distinctions between single-and multishot devices, our approach provides rigorous criteria for determining when measurements can truly resolve individual laser shots rather than statistical averages. By contextualizing single measurements, this framework shows that single-shot capability is not an intrinsic d...
• Aberrant X chromosome dosage compensation causes hybrid male inviability in Caenorhabditis AI翻译
  作者：Li, Yongbin; Gao, Yimeng; Ma, Jiaonv; Gao, Yifan; Tang, Jiemei; Yang, Rui; Wang, Jiajia; Zhou, Wangyan; Zhang, Hantang; Shao, Wenhua; Liu, Zhijin; Zhao, Zhongying; Liu, Xiao
  作者单位：Capital Normal University; Hong Kong Baptist University
  摘要：Zygotic reproductive isolation frequently initiates with hybrid incompatibility in the heterogametic sex, such as males in XX/XY systems. The genetic basis of hybrid male incompatibility has long remained elusive. Here, we show that crosses of Caenorhabditis nigoni males with C. briggsae females result in insufficient expression of Cbr- xol- 1, an X- linked master switch responsible for intimately linked sex determination and dosage compensation pathways, consequently triggering aberrant X- ch...
• The moving mantle beneath Hawaii: A new look at an old bend AI翻译
  作者：Muller, R. Dietmar
  作者单位：University of Sydney
• Smartphone use in a large US adult population: Temporal associations between objective measures of usage and mental well- being AI翻译
  作者：Winbush, Ari; Mcduff, Daniel; Hernandez, John; Barakat, Andrew; Jiang, Allen; Heneghan, Conor; Nelson, Benjamin W.; Allen, Nicholas B.
  作者单位：University of Oregon; Alphabet Inc.; Google Incorporated; Alphabet Inc.; Google Incorporated
  摘要：Smartphones are essential tools in daily life yet concerns persist about their potential effects on mental health and well-being. Research on these relationships often relies on subjective measures of smartphone use, which can lack validity. These studies are also often limited by small, homogenous samples and the inability to differentiate between types of smartphone activities (e.g., social media vs. other applications). In this study, we analyzed 250,000 d of smartphone usage data from 10,0...
• Transcriptional condensates encode a golden mean to optimize enhancer-promoter communication across genomic distances AI翻译
  作者：Zhu, Tao; Li, Chunhe; Chu, Xiakun
  作者单位：Fudan University; Hong Kong University of Science & Technology (Guangzhou); Fudan University; Fudan University; Hong Kong University of Science & Technology (Guangzhou)
  摘要：Enhancers regulate gene expression by physically contacting their target promoters, yet these contacts often span large genomic distances. Phase-separated condensates (droplet-like clusters) of transcription factors (TFs) are thought to facilitate such long-range enhancer-promoter (E-P) communication, but the quantitative principles underlying this mechanism remain unclear. Here, we use polymer-based chromatin simulations to systematically vary the strength of TF clustering and the E-P genomic...
• The dominant sink of oceanic calcium carbonate occurs in undersaturated seawater AI翻译
  作者：Wu, Yiwei; Huang, Yuefei; Devries, Timothy; Liang, Hengdi; Wang, Guangqian; Zhang, Shuo
  作者单位：Tsinghua University; Qinghai University; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; Massachusetts Institute of Technology (MIT)
  摘要：Calcium carbonate (CaCO3) particles formed by marine organisms dissolve in seawater and on the ocean floor, constituting a key component of the global ocean carbon cycle. However, neither the magnitude nor the distribution of CaCO3 dissolution in the modern oceans is well constrained. Here we diagnose CaCO3 dissolution rates in major oceanic regions and reconstruct CaCO3 settling flux using a data-constrained ocean circulation model and observational climatologies of global seawater alkalinity...
• Exceptional diversity of allorecognition receptors in a nonvertebrate chordate reveals principles of innate allelic discrimination AI翻译
  作者：Valbuena, Henry Rodriguez-; Salcedo, Jorge; De Thier, Olivier; Flot, Jean Francois; Tiozzo, Stefano; De Tomaso, Anthony W.
  作者单位：University of California System; University of California Santa Barbara; Universite Libre de Bruxelles; Centre National de la Recherche Scientifique (CNRS)
  摘要：Highly polymorphic allorecognition systems have been characterized in numerous invertebrate species, and exhibit discriminatory capabilities reminiscent of vertebrate adaptive immunity. As these systems utilize germline encoded receptors, the mechanisms underlying allelic discrimination are unknown. The invertebrate chordate, Botryllus schlosseri, undergoes a natural transplantation reaction controlled by a highly polymorphic, polygenic locus (called the fuhc) with over 1,000 allelic haplotype...
• Adipose cullin 3 mediates the antiobesity effect of pan neddylation inhibitors AI翻译
  作者：Gu, Lijie; Du, Yanhong; Hasan, Mohammad Nazmul; Clayton, Yung-Dai; Li, Tiangang
  作者单位：University of Oklahoma System; University of Oklahoma Health Sciences Center
  摘要：Cullin Ring E3 Ligases (CRLs) belong to the largest family of multisubunit ubiquitin E3 ligases. A cullin serves as the scaffold protein that recruits E3 ligases and substrate receptors in a CRL complex, whose activity requires cullin neddylation, a posttranslational modification that can be pharmacologically targeted by neddylation inhibitors. Elevated neddylation activity has been observed in the liver and adipose tissue of obese mice, implicating a pathogenic link between altered CRL activi...
• Single-cell metabolome and RNA-seq multiplexing on single plant cells AI翻译
  作者：Kang, Moonyoung; Vu, Anh Hai; Casper, Abbie L.; Kim, Rinho; Wurlitzer, Jens; Heinicke, Sarah; Yeroslaviz, Assa; Caputi, Lorenzo; O'connor, Sarah E.
  作者单位：Max Planck Society; Max Planck Society
  摘要：Plants produce valuable natural products used for a wide variety of industrial applications. Thus, there is enormous interest in elucidating the biosynthetic pathways that are responsible for the production of these compounds. Identification of the genes that comprise these biosynthetic pathways has been enabled by gene-to-metabolite networks that are generated from transcriptomic and metabolomic datasets. Recent advances in both single-cell RNA-seq (scRNA-seq) and single-cell mass spectrometr...