7期

最新文章

• Charge acceleration without radiation AI翻译
  作者：Aharonov, Y.; Collins, D.; Popescu, S.
  作者单位：Chapman University System; Chapman University; Chapman University System; Chapman University; Tel Aviv University; University of Bristol
  摘要：The existence of electromagnetic radiation-radio waves, microwaves, light, X-rays, and so on-is one of the most important physical phenomena, and our ability to manipulate them is one of the most significant technological achievement of humankind. Underlying this ability is our understanding of how radiation is produced: Whenever an electric charge is accelerated, it radiates. Or, at least, this is how it has been hitherto universally thought. Here, we prove that quantum mechanically electric ...
• A c-Cbl/Cbl-b antagonist inhibits EGFR ubiquitylation and sustains EGFR phosphorylation to enhance corneal re-epithelialization AI翻译
  作者：Tarvestad-Laise, Kate; Monsen, Robert C.; Crotchett, Brandon L. M.; Rush, Jamie S.; Ganipisetti, Srinivasrao; Valmon, Rajachandrasekhar; DeLeeuw, Lynn; Burlison, Joseph; Trent, John O.; Ceresa, Brian P.
  作者单位：University of Louisville; University of Louisville; University of Louisville
  摘要：Growth factor receptor signaling is a critical component of tissue growth, homeostasis, and wound healing. However, receptor desensitization limits the use of exogenous growth factors as a restorative agent therapeutically. An example of this is the epidermal growth factor receptor (EGFR) in the corneal epithelium. Despite laboratory data indicating that EGFR activity accelerates corneal re-epithelialization in mice and rabbits, the clinical administration of EGF to damaged corneal epithelium ...
• Scaling laws for function diversity and specialization across socioeconomic and biological complex systems AI翻译
  作者：Yang, Vicky Chuqiao; Holehouse, James; Youn, Hyejin; Arroyo, Jose Ignacio; Redner, Sidney; West, Geoffrey B.; Kempes, Christopher P.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); The Santa Fe Institute; Seoul National University (SNU); University of London; London School Economics & Political Science
  摘要：Function diversity, the range of tasks individuals perform, and specialization, the distribution of function abundances, are fundamental to complex adaptive systems. In the absence of overarching principles, these properties have appeared domain-specific. Here, we introduce an empirical framework and a mathematical model for the diversification and specialization of functions across disparate systems, including bacteria, federal agencies, universities, corporations, and cities. We find that th...
• Whole-body central processing of lateral line inputs encodes fow direction relative to the center-of-mass AI翻译
  作者：Lunsford, Elias T.; Carbo-Tano, Martin; Wyart, Claire
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); University of Copenhagen
  摘要：From shifting visual scenes to tactile deformations and fluid motion, animals interpret patterns of sensory flow around their body to construct internal models and produce adaptive behavior. Understanding how such transformations are encoded in the brain remains incomplete. To tackle this question, we leverage the lateral line of larval zebrafish as a tractable system sensitive to fluid motion and used to steer navigation, feed, and avoid predators. By presenting stimuli of either direction to...
• Photoenzymatic Csp3-Csp3 bond formation via enzyme-templated radical-radical coupling AI翻译
  作者：Liu, Yi; Oblinsky, Daniel G.; Dell'Orletta, Gianluca; Di Fonte, Nico; Sorigue, Damien; Page, Claire G.; Daidone, Isabella; Scholes, Gregory D.; Hyster, Todd K.; Benkovic, Stephen J.
  作者单位：Princeton University; University of L'Aquila; CEA; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS)
  摘要：Cross-couplings are essential reactions in modern chemical synthesis, enabling the rapid construction of complex molecules from simple precursors. Transition metal catalysts are prized for these transformations because their reactivity and selectivity can be tuned via judicious selection of the metal and ligand. Although enzymes offer analogous opportunities for tuning via protein engineering, their application to cross-coupling remains limited, as nature relies on alternative paradigms for bu...
• Short-range electrostatic screening in ionic liquids as inferred by direct force measurements AI翻译
  作者：Cross, Benjamin; Garcia, Leo; Charlaix, Elisabeth; Kekicheff, Patrick
  作者单位：Communaute Universite Grenoble Alpes; Centre National de la Recherche Scientifique (CNRS); Universite Grenoble Alpes (UGA); Universites de Strasbourg Etablissements Associes; Centre National de la Recherche Scientifique (CNRS); Universite de Strasbourg; CNRS - Institute of Chemistry (INC)
  摘要：Previous experimental reports of long-range interactions in ionic liquids (ILs) stand in contradiction with theoretical predictions and numerical simulations. To provide insights into the literature discrepancies regarding the experimental ranges of electrostatic screening, claimed with orders of magnitude larger, the interactions between pairs of mica and borosilicate surfaces confining ILs are investigated by two complementary advanced Surface Force Apparatuses. Regardless of differences in ...
• ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivation AI翻译
  作者：Dhaliwal, Navroop K.; Weng, Octavia Yifang; Tian, Ai; Aggarwal, Aditi; Ahmed, Mai; Sun, Guoria; Bhattacharya, Afrin; Choi, Wendy W. Y.; Nishimura, Haruka; Chakraborty, Pragnya; Dong, Xiaoxue; Wu, Yuncheng; Wilson, Michael D.; Wang, Lu -Yang; Parada, Luis F.; Muffat, Julien; Li, Yun
  作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); Shanghai Jiao Tong University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center
  摘要：Mutations in the phosphatase and tensin homolog (PTEN) gene are linked to severe neurodevelopmental disorders. Loss ofPTENcauses hyperactivation of both mechanistic target of rapamycin (mTOR) complexes, mTORC1 and mTORC2. Recent studies have shown that this dual hyperactivation is required for the neuropathology observed in PTEN-deficient human stem cell-derived neural cells. However, the molecular effectors that integrate these synergistic signals remain unknown. Here, we identify the actin-r...
• The psychological ability to adopt recommended coping responses reduced infections during the COVID-19 pandemic AI翻译
  作者：Hansen, Lasse Hyldig; Jorgensen, Frederik; Petersen, Michael Bang
  作者单位：Aarhus University
  摘要：During the COVID-19 pandemic, a key question for researchers and authorities was to understand the psychological motivations that sustained public engagement in protective behavior such as physical distancing and hygienic protection. While feelings of threat were rampant during the pandemic, theories of health psychology have highlighted appraisals related to the ability to cope (e.g., the feeling of being able to adhere cost-effectively to government advice) and argued that coping appraisals ...
• Mining lysine post-translational modification sites by integrating protein language model representations with structural context AI翻译
  作者：Luo, Mengqi; Zhu, Xiaohong; Bai, Chen; Warshel, Arieh; Chen, Luonan
  作者单位：Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Southern California; Shanghai Jiao Tong University; Shanghai Jiao Tong University
  摘要：Lysine (Lys/K) residues serve as major hubs for post-translational modifications (PTMs) owing to the chemical versatility of their 8-amino groups, giving rise to diverse regulatory functions. Accurate and efficient identification of modified lysine residues therefore requires computational models that can effectively capture both sequence and structural information while minimizing domain-specific feature engineering. In this study, we propose a unified deep learning framework for lysine PTM s...
• Nonlinear diffusion and decay of a blob of turbulence spreading into a quiescent fluid AI翻译
  作者：Matsuzawa, Takumi; Zhu, Minhui; Goldenfeld, Nigel; Irvine, William T. M.
  作者单位：University of Chicago; Cornell University; University of Illinois System; University of Illinois Urbana-Champaign; United States Department of Energy (DOE); Argonne National Laboratory; University of California System; University of California San Diego; University of Chicago
  摘要：Turbulence, left unforced, evolves under its own dynamics, invading surrounding quiescent fluid as it decays. A ubiquitous and familiar phenomenon, this fundamental aspect of turbulence has resisted the marriage of principled theory and experiment with no universal law yet capturing its evolution. Conventional flow chamber experiments have been hampered by boundary effects or strong mean flows that obscure the intrinsic dynamics of relaxation to quiescence. To circumvent these limitations, we ...