7期

最新文章

• High-speed in situ tomographic imaging at lab scale AI翻译
  作者：Aly, Abdallah; Saif, M. Taher A.
• Dual quantum locking: Dynamic coupling of H2 and H2O sublattices in hydrogen-filled ice AI翻译
  作者：Renaud, Loan; Poreba, Tomasz; Di Cataldo, Simone; Nicholls, Alasdair; Andriambariarijaona, Leon; Rescigno, Maria; Gaal, Richard; Casula, Michele; Saitta, A. Marco; Bove, Livia Eleonora
  作者单位：Sorbonne Universite; Museum National d'Histoire Naturelle (MNHN); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite PSL; Universite Paris Cite; Ecole Normale Superieure (ENS); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Sapienza University Rome; CEA; Centre National de la Recherche Scientifique (CNRS); Institut Polytechnique de Paris; Sorbonne Universite; Ecole Polytechnique; Institut Laue-Langevin (ILL)
  摘要：Hydrogen hydrates (HH) are a unique class of materials composed of hydrogen molecules confined within crystalline water frameworks. Among their multiple phases, the filled ice structures, particularly the cubic C2 phase, exhibit exceptionally strong host-guest interactions due to ultra-short H2-H2O distances and a 1:1 stoichiometry leading to two interpenetrated identical diamond-like sublattices, one comprised of water molecules, the other of hydrogen molecules. At high pressures, nuclear-qua...
• Lipid nanoparticle GM-CSF replacement for autoimmune pulmonary alveolar proteinosis AI翻译
  作者：Lian, Liming; Jang, Bora; Huayamares, Sebastian G.; Shakked, Avraham; Gentry, Kara; Zenhausern, Ryan; Radmand, Afsane; Echeverri, Elisa Schrader; Parihar, Vaunita C.; Guerrero-Ferreira, Ricardo C.; Calkins, Randi; Vanover, Daryll; Santangelo, Philip J.; Kim, Hyejin; Dahlman, James E.
  作者单位：Emory University; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Emory University; Emory University
  摘要：Granulocyte-macrophage colony-stimulating factor (GM-CSF) deficiency drives autoimmune pulmonary alveolar proteinosis (aPAP), a disease characterized by impaired macrophage-mediated clearance of pulmonary surfactants. Clinical data suggest that inhaled recombinant GM-CSF reduces symptoms in aPAP patients, providing a rationale for mRNA-based GM-CSF replacement therapies. However, these require effective mRNA delivery after nebulization. Here, we report the iterative in vivo design of a lipid n...
• What is the general Welfare: Welfare economic perspectives on equity AI翻译
  作者：Manski, Charles F.
  作者单位：Northwestern University; Northwestern University
  摘要：Researchers cannot definitely interpret what the framers of the United States Constitution intended when theywrote of the general Welfare. Nevertheless, researchers can conjecture by specifying social welfare functions that aim to express the preferences of the population. An extensive literature in welfare economics addresses the matter. Nevertheless, economists have often simplified policy analysis by assuming that individuals have homogeneous, consequentialist, and self-centered preferences...
• Diverse, distinct, and densely packed DNA nanostar droplets AI翻译
  作者：Chaderjian, Aria S.; Wilken, Sam; Saleh, Omar A.
  作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara
  摘要：The liquid-liquid phase separation of biomolecules is an important process for intracellular organization. Biomolecular sequence combinatorics leads to a large variety of proteins and nucleic acids which can interact to form a diversity of dense liquid (condensate) phases. The relationship between sequence design and the diversity of the resultant phases is therefore of interest. Here, we explore this question using the DNA nanostar system which permits the creation of multiphase condensate dr...
• Conservation and environmental management reimagined: Toward anti-oppressive futures AI翻译
  作者：German, Laura; Abrams, Jesse; Struthers, Cory L.; Pictou, Sherry; Woodson, C. Brock; Kumar, Suneel; Cabe, Tommy; Merino, Roger; King, Elizabeth
  作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; United States Department of Energy (DOE); University System of Georgia; Savannah River Ecology Laboratory; University of Georgia; University of Washington; University of Washington Seattle; Dalhousie University; University System of Georgia; University of Georgia; University of Sindh; Universidad del Pacifico Peru; University System of Georgia; University of Georgia
  摘要：Conservation and environmental management are under increased scrutiny as the embeddedness of oppressive practices has gained wider societal and scholarly attention. As conservation and environmental practitioners and scholars grapple with foundational assumptions and practices of the field, there remains a pressing need to identify persistent problematic legacies and articulate a positive vision for conservation grounded in an ethic of justice. To help advance this conversation, we present a ...
• More social interactions, more polarization? The evidence is not there AI翻译
  作者：Volker, Beate; Corten, Rense; Mollenhorst, Gerald
  作者单位：Vrije Universiteit Amsterdam; Utrecht University; Utrecht University
• Allosteric coupling between PIP2 and Ca2+binding sites gates TMEM16A channels AI翻译
  作者：Xu, Jie; Santa-Cruz, Ana; Chandrashekar, Aishwarya; Kawano, Takeharu; Kissell, R. Charles; Zaka, Mehreen; Zhang, Zhe; Cui, Meng; Logothetis, Diomedes E.; Plant, Leigh D.
  作者单位：Northeastern University; Northeastern University; Xuzhou Medical University
  摘要：TMEM16A channels conduct Ca2+-activated Cl-currents that underlie essential physiological processes including epithelial secretion, smooth muscle contraction, and sensory transduction. Channel activation requires both intracellular Ca2+ and the signaling phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2), yet the molecular basis of this dual regulation has remained unclear. Using gating molecular-dynamics simulations and structure-guided electrophysiology, we show that PIP2 andCa2+coope...
• A systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas AI翻译
  作者：Chan, Marina; Zhu, Songli; Russell, Zachary R.; Arora, Sonali; Arakaki, Aleena K. S.; Vaz, Joel M.; Kumasaka, Deby; Szulzewsky, Frank; Michealraj, Antony; Holland, Eric C.; Gujral, Taranjit S.
  作者单位：Fred Hutchinson Cancer Center; Utah System of Higher Education; University of Utah; Huntsman Cancer Institute; Utah System of Higher Education; University of Utah; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Ependymomas (EPN) are rare central nervous system tumors that account for approximately 10% of intracranial tumors in children and 4% in adults. Despite their clinical and molecular heterogeneity, spanning supratentorial, posterior fossa, and spinal subtypes, treatment remains limited to surgery and radiotherapy, with chemotherapy offering minimal benefit. Here, we performed transcriptomic analysis of 370 human ependymoma samples and identified two distinct molecular subgroups: EPN-E1 and EPN-...
• Methionine-specific nonreversible bioconjugation: Advancing precision protein modification AI翻译
  作者：Wang, Shirui; Zhang, Zhenguo; Tio, Raymond; Li, Bohan; Khoo, Joycelyn Yi Xin; Loh, Teck -Peng
  作者单位：Great Bay University; Nanyang Technological University; Henan University of Technology
  摘要：We present a methionine-selective, nonreversible bioconjugation strategy that employs activated allylic bromides under mild, aqueous reaction conditions compatible with various peptides and proteins. Compared with conventional allylic bromides, our method improves conjugate stability and suppresses nonspecific reactivity under the examined reaction conditions. This method enables methionine-preferred labeling of peptides and proteins, and provides proof-of-concept applications in covalent inhi...