7期

最新文章

• Metabolic stress conditions dictate MAPKAPK2-dependent efficiency of MEK 1/2 inhibition in colorectal carcinoma AI翻译
  作者：Kumari, Niti; Chen, Xu; Baldwin, Amber M.; Clemons, Kristin I.; El-Harakeh, Mohammad; Calisto, Lilian E.; Kumar, Balawant; Zhang, Qiaoqiao; Min, Jiang; Xiao, Bin; Singh, Amar B.; Wang, Bin; North, Brian J.
  作者单位：Creighton University; Chongqing Medical University; Jinfeng Laboratory; University of Kansas; University of Kansas Medical Center; Chongqing Medical University; Army Medical University
  摘要：The kinase MAPKAPK2 regulates cell survival, proliferation, and death, and is upregulated in colorectal carcinoma (CRC) where it is associated with tumor growth and progression. However, how it regulates tumor progression in conjunction with other signaling pathways, such as MEK/ERK, remains elusive. Solid tumors are often subjected to metabolic stress, notably glucose deprivation. Here, we demonstrate that MAPKAPK2 protein levels in CRC regulate cell fate decision during stress conditions, su...
• Coupled anatexis and extreme differentiation are the keys for producing giant lithium-rich pegmatites AI翻译
  作者：Wei, Hai-Zhen; Palmer, Martin R.; Xu, Zhiqin; Zhu, Wenbin; Xu, Xi-Sheng; Williams-Dones, Anthony; Zheng, Bi-Hai; Gao, Jian-Guo; Wang, Qin; Ma, Ding; Yang, Ke; Lin, Hefeng; Zuo, Da-Sheng
  作者单位：Nanjing University; Nanjing University; Nanjing University; University of Southampton; NERC National Oceanography Centre; McGill University; Nanjing University
  摘要：Despite the economic importance of lithium, there is considerable disagreement over the processes that concentrate it and other rare metals in pegmatite-type lithium deposits. Two main processes have been invoked, namely extreme differentiation of a peraluminous granitic magma and direct anatexis of a sedimentary protolith. We use geochemical modeling to quantify lithium enrichment via these two processes from a study of the Jiajika lithium pegmatite field, one of the largest of its type in th...
• Decoding antibody response to MERS-CoV in wild dromedary camels AI翻译
  作者：Idoudi, Faten; Wang, Ruoke; Tian, Long; Yang, Ziqing; Chik, Kenn Ka-Heng; Chen, Peng; Benabderrazek, Rahma; Fu, Lili; Tan, Ruijie; Dhaouadi, Sayda; Benlasfar, Zakaria; Somia, Mahmoud; Zhang, Qi; Shi, Xuanling; Chan, Jasper Fuk-Woo; Yuen, Kwok -Yung; Wang, Xinquan; Bouhaouala-Zahar, Balkiss; Zhang, Linqi
  作者单位：Universite de Tunis-El-Manar; Pasteur Network; Institut Pasteur Tunis; Tsinghua University; Universite de Carthage; Tsinghua University; University of Hong Kong; Universite de Tunis-El-Manar; Faculte de Medecine de Tunis (FMT); Tsinghua University; Tsinghua Shenzhen International Graduate School; Shenzhen Bay Laboratory
  摘要：Wild dromedary camels in the Arabian Peninsula and Africa have harbored antibodies against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) for decades, predating zoonotic spillover to humans. However, the potency, specificity, and structural characteristics of these antibodies remain poorly understood. Here, we characterize the antibody responses of naturally infected wild dromedary camels in Tunisia, a MERS-CoV-endemic region. Plasma antibodies from nine camels exhibited variable neut...
• Bimodal dynamics of viscous pearls AI翻译
  作者：Despointes, Auriane Huyghues; Kushwaha, Abhijit Kumar; Fresnais, Jerome; Truscott, Tadd; Quere, David
  作者单位：Universite PSL; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Paris Cite; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); CNRS - Institute for Engineering & Systems Sciences (INSIS); King Abdullah University of Science & Technology; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite
  摘要：Droplets on super-repellent materials adopt the shape of pearls, which makes them highly mobile, owing to the conjunction of low contact line pinning with small dynamical friction. This property is especially valuable when drops are viscous, a case where we expect super-repellency to minimize the friction associated with viscosity. Here, we report that viscous droplets on highly repellent inclines can have two modes of descent, depending on the way they are deposited: either they run at the fa...
• High-speed atomic force microscopy reveals a surface-catalyzed elongation mechanism of the fungal functional amyloid hydrophobin RolA AI翻译
  作者：Takahashi, Nao; Kimura, Tatsuya; Terauchi, Yuki; Tanaka, Takumi; Abe, Natsuki; Yoshimi, Akira; Abe, Keietsu; Watanabe-Nakayama, Takahiro
  作者单位：Tohoku University; Kanazawa University; Yamaguchi University; Kyoto University; Kyoto University
  摘要：Hydrophobins are functional amyloids conserved in filamentous fungi. They act as a protective coat in the fibrous form, called rodlet. Rodlets further assemble to form dense films where they are bundled and densely aligned, contributing to the hydrophobicity of the mycelium surface. The mechanism of this dense film formation is completely unknown. Here, we used high-speed atomic force microscopy to directly observe the structural dynamics of rodlet bundling and subsequent film formation by hyd...
• Sound reasons for tympanic hearing in mammalian precursors AI翻译
  作者：Schmitz, Lars
  作者单位：Claremont Colleges; Claremont McKenna College; Claremont Graduate University
• Antagonism of RNA silencing in the yellow fever mosquito, Aedes aegypti, by the nsP2 protein of the prototype alphavirus AI翻译
  作者：Gupta, Adarsh K.; Wiley, Michael R.; Myles, Kevin M.
  作者单位：Texas A&M University System; Texas A&M University College Station; University of Nebraska System; University of Nebraska Medical Center
  摘要：Alphaviruses establish persistent infections in mosquito vectors despite robust antiviral RNA interference (RNAi) pathways, suggesting that they employ mechanisms to counteract host immunity. We demonstrate that the nsP2 protein of Sindbis virus (SINV), the prototype alphavirus, functions as a viral suppressor of RNA silencing in Aedes aegypti mosquitoes. Using a SINV mutant (2V) that prevents cleavage at the nsP2-nsP3 junction, we show that proper proteolytic processing to release mature nsP2...
• James D. Watson (1928-2025): Influencer of science and society AI翻译
  作者：Witkowski, Jan; Stillman, Bruce
  摘要：James Dewey Watson who died on November 7, 2025, at the age of 97, was a towering figure in 20th century life science. With Francis Crick, he determined the structure of DNA, laying the foundation of modern biology; he made Cold Spring Harbor Laboratory one of the world's great biomedical research institutes and a center for professional education in molecular biology and neuroscience; he established the Human Genome Project and ensured that research on the associated ethical, legal, and socia...
• Next-gen geothermal could bring clean power to much more of the planet AI翻译
  作者：Battersby, Stephen
• The cultural evolution of pluralistic ignorance AI翻译
  作者：Gavrilets, Sergey; Karl, Johannes; Gelfand, Michele J.
  作者单位：University of Tennessee System; University of Tennessee Knoxville; University of Tennessee System; University of Tennessee Knoxville; Communaute d'universites et etablissements de Toulouse (Comue); Universite Toulouse 1 Capitole; Toulouse School of Economics; Victoria University Wellington; University of Zurich; Stanford University
  摘要：Pluralistic ignorance-the systematic misperception of others' attitudes-can entrench suboptimal norms, yet its dynamics remain poorly understood. We develop a mathematical model of the coevolution of actions, private attitudes, and beliefs about others, with societal tightness as a central parameter. Our framework integrates theories of spirals of silence, preference falsification, and cultural mismatch into a single dynamic system capturing the effects of material payoffs, cognitive forces, a...