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作者：Fernandez, Vicente I.; Blitvic, Natasha; Keegstra, Johannes M.; Stocker, Roman
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of London; Queen Mary University London
摘要：Heterotrophic bacteria play a central role in attenuating the sequestration of carbon to the deep ocean by degrading sinking marine particles. The role of certain copiotrophic adaptations such as surface attachment and motility in particle degradation has remained unclear outside of coastal regions, where the sparsity of particles would appear to preclude a foraging lifestyle based on particle hopping. We show here instead that many oligotrophic marine environments are much more amenable to co...
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作者：Perreault, Charles
作者单位：Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe
摘要：Humans occupy a geographic and ecological range wider than that of any other extant vertebrates, having rapidly expanded into nearly every habitat on the planet. This expansion was driven not only by biological adaptations but, crucially, by cultural evolution-a process that enabled the rapid and cumulative acquisition of adaptive behaviors and technologies. Here, I quantify the unique contribution of cultural evolution by comparing the global human range to mammalian ranges aggregated at vari...
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作者：Tang, Rong-Chun; Tang, Zhiheng; Yu, Shuang-Shuang; Zhang, Ao; Geng, Shijin; Yu, Hengxiang; Zhou, Yunxuan; Zhang, Lan; Liu, Xiaoyun; Zhang, Jun
作者单位：Peking University; Peking University; Peking University
摘要：Linear ubiquitination and deubiquitination represent critical regulatory mechanisms in inflammation and cell death, yet their roles in RIG-I-like receptor (RLR)-dependent signaling remain unclear. Here, we identified OTU deubiquitinase with linear linkage specificity (OTULIN) as a negative regulator of RIG-I-dependent type I IFN (IFN-I) signaling. Overexpression of OTULIN markedly attenuated NF-kappa B and IFN beta reporter activation triggered by RNA viruses or synthetic analogs, suppressed d...
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作者：Liu, Helen W.; Khera, Radhika; Grob, Patricia; Gallaher, Sean D.; Purvine, Samuel O.; Nicora, Carrie D.; Lipton, Mary S.; Niyogi, Krishna K.; Nogales, Eva; Iwai, Masakazu; Merchant, Sabeeha S.
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作者：Rodriguez-Vazquez, Elvira; Aranda-Torrecillas, Alvaro; Jimenez-Puyer, Manuel; Freire-Agulleiro, Oscar; Sanchez-Tapia, Maria J.; Ruiz-Cruz, Miguel; Heras, Violeta; Lopez-Sancho, Maria; Ongaro, Luisina; Perdices-Lopez, Cecilia; Bernard, Daniel J.; Pineda, Rafael; Gaytan, Francisco; Lopez, Miguel; Castellano, Juan M.; Tena-Sempere, Manuel
作者单位：Universidad de Cordoba; Hospital Universitario Reina Sofia - Cordoba; CIBER - Centro de Investigacion Biomedica en Red; Instituto de Salud Carlos III; CIBEROBN; Universidade de Santiago de Compostela; McGill University; McGill University
摘要：Early-onset obesity, especially in girls, is frequently associated with advanced puberty; a phenomenon bound to increased risk of long-term complications. Hypothalamic endoplasmic reticulum (ER) stress has been implicated in the pathophysiology of obesity and its comorbidities. However, its contribution to pubertal disorders associated with obesity remains unexplored. We report herein that central ER stress drives obesity-induced precocious female puberty. Hypothalamic expression of key ER str...
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作者：Ding, Xiao-Hong; Chen, Fenfang; Yang, Fan; Di, Gen-Hong; Shao, Zhi-Ming; Xiao, Yi; Jiang, Yi-Zhou
作者单位：Fudan University; Fudan University; Fudan University
摘要：Luminal breast cancer is characterized by a persistent risk of recurrence and dysregulated lipid metabolism. However, the role of phase separation, a novel mechanism for the spatial compartmentalization of proteins, in lipid remodeling within the context of breast cancer remains largely unexplored. Utilizing the multiomics data from our large breast cancer cohort (n = 773), we revealed that aberrant lipid metabolism negatively impacts the prognosis of patients with luminal breast cancer. Furth...
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作者：Liew, Jun Hao; Norman, Ayuni; Illouz, Morgane; Teo, Teck-Hui; Delli Ponti, Riccardo; Hamela, Claire; Mohan, Lalit; Lew, Renee; Ron, Chanvutha; Low, Kay En; Daher, Wassim; Chiam, Aryeh; Maw, Joanna; Sun, Yan; Sorayah, Ria; Oehlers, Stefan H.; Jhun, Byung Woo; Teo, Jeanette W. P.; Goulet, Adeline; Bonne, Isabelle; Wintjens, Rene; Pethe, Kevin; Huber, Roland G.; Kremer, Laurent; Bifani, Pablo
作者单位：Agency for Science Technology & Research (A*STAR); A*STAR Infectious Diseases Labs (A*STAR IDL); National University of Singapore; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Agency for Science Technology & Research (A*STAR); Nanyang Technological University; National University of Singapore; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier; Sungkyunkwan University (SKKU); Samsung Medical Center; National University of Singapore; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; National University of Singapore; Universite Libre de Bruxelles
摘要：Mycobacterium abscessus infections represent a growing global health concern due to their severe pathology and difficulty of treatment, largely driven by their intrinsic antimicrobial resistance. While phage therapy has emerged as a promising alternative approach, studies have predominantly focused on glycopeptidolipids (GPL)-deficient M. abscessus rough variants instead of the GPL-producing smooth variants predominant in Asia. Here, we aim to develop phage cocktails targeting both smooth and ...
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作者：Wang, Feng; He, Qing; O'Donnell, Michael E.; Li, Huilin
作者单位：Van Andel Institute; Rockefeller University; Howard Hughes Medical Institute; Rockefeller University
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作者：Wei, Shiqiang; Zhou, Quan; Chen, Shuangming; Wang, Yixiu; Zhang, Pengjun; Jiang, Wei; Wang, Changda; Cui, Jiewu; Wu, Xiaojun; Song, Li
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Hefei University of Technology; Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要：Understanding solvent/solute-borne coordination structures and their impact on electrode intercalation chemistry is crucial for the rational design of high-performance electrolytes. Nevertheless, the anion coordination mechanisms governing solvation structures and their influence on electrochemical properties within aqueous zinc-ion electrolytes remain insufficiently explored. In this work, we systematically elucidate the Zn2+ coordination environments in dilute aqueous zinc-ion electrolytes c...
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作者：Xiao, Wanyue; Kuang, Wenjian; Huang, Sibo; Liang, Shanjun; Ping, Din; Wang, Shubo
作者单位：City University of Hong Kong; Hong Kong Polytechnic University; City University of Hong Kong; Shanghai Jiao Tong University
摘要：Phase control is fundamental to acoustic wave manipulation. The propagation and resonant phases have been widely used to modulate acoustic waves. However, the real-space geometric phase, also known as the Pancharatnam-Berry (PB) phase, has remained elusive in acoustics, owing to the fact that airborne sounds are curl-free longitudinal waves lacking intrinsic polarization degrees of freedom. Here, we theoretically and experimentally demonstrate that the PB phase can emerge in inhomogeneous soun...
