11期

最新文章

• Online supervised learning of temporal patterns in biological neural networks under feedback control AI翻译
  作者：Sono, Yuki; Yamamoto, Hideaki; Nishi, Yusei; Sumi, Takuma; Sato, Yuya; Hirano-Iwata, Ayumi; Katori, Yuichi; Sato, Shigeo
  作者单位：Tohoku University; Tohoku University; Tohoku University; University of Calgary; Tohoku University; Waseda University; Future University Hakodate; University of Tokyo
  摘要：In vitro biological neural networks (BNNs) provide well-defined model systems for constructively investigating how living cells interact with their environments to shape high-dimensional dynamics that can be used to generate coherent temporal outputs, such as those required for motor control. Here, we develop a real-time closed-loop BNN system that is capable of generating periodic and chaotic temporal signals by integrating cultured cortical neurons with microfluidic devices and high-density ...
• A soft electrode array with reconfigurable hydrogel interfaces for high-fidelity neurophysiological monitoring during craniotomy AI翻译
  作者：Yang, Ganguang; Pang, Bo; Gong, Hangyu; Qiu, Yuqi; Gong, Caixin; Zhou, Sen; Zheng, Qingyang; Wang, Zhixin; Bu, Tianzhao; Xu, Shabei; Luo, Xiang; Qiao, Haiyan; Yin, Zhouping; Wu, Changsheng; Wu, Hao
  作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; Huazhong University of Science & Technology
  摘要：Achieving accurate monitoring of electrophysiological activity from the brain cortex is critical for preventing postoperative neurological deficits during craniotomy. However, current technologies face profound challenges in enabling consistent high-quality neu ral signal acquisition due to complex intracranial environments (e.g., wet/fragile brain surfaces and surgical instrument interference). Here, we develop a soft electrode array with reconfigurable hydrogel interfaces for sustainable hig...
• Oligomerization of PER2 as a dynamic mode of regulation of the mammalian circadian clock AI翻译
  作者：Sanyal, Paulomi; Sharma, Diksha; Viswan, Akhila; Crosby, Priya; Narayanan, Vaishali; Baumgartner, Jackson; Partch, Carrie L.; Sekhar, Ashok
  作者单位：Indian Institute of Science (IISC) - Bangalore; University of California System; University of California Santa Cruz; Howard Hughes Medical Institute; University of California System; University of California Santa Cruz; University of Edinburgh
  摘要：PER2 is a central transcriptional regulator in the mammalian circadian clock that closes the negative transcription-translation feedback loop by repressing its own transcription. The balance between the synthesis of PER2 and its degradation is a key factor that determines the circadian period. PER2 stability hinges on antagonistic phosphorylation events-phosphorylation at the familial advanced sleep phase site stabilizes PER2 while phosphorylation at the phosphodegron promotes degradation. The...
• Directed differentiation of bovine trophoblast stem cells: A useful in vitro model for placenta development AI翻译
  作者：Abdelhady, Abdallah W.; Winuthayanon, Sarayut; Ortega, M. Sofia; Kelleher, Andrew M.; Spencer, Thomas E.
  作者单位：University of Missouri System; University of Missouri Columbia; University of Wisconsin System; University of Wisconsin Madison; University of Missouri System; University of Missouri Columbia
  摘要：Cattle have a synepitheliochorial type of placenta characterized by placental cotyledons and maternal endometrial caruncles forming placentomes that are essential for fetal development to term. As the elongated conceptus begins implantation, binucleated trophoblast giant cells (TGC) begin to appear in the chorion. The TGC are hypoth esized to arise from progenitor UNC through endoreplication and express unique placenta-specific genes, including placental lactogen (CSH2), pregnancy-associated g...
• SypC, a symbiont outer membrane vesicle protein, impacts the development of the squid-vibrio partnership AI翻译
  作者：Kuwabara, Jill T.; Beilinson, Vera; Hargadon, Alexis C.; Chen, Grischa Y.; Hu, Xiao-Meng; Ladinsky, Mark S.; Hackett, Kathleen T.; Dillard, Joseph P.; Visick, Karen L.; Ruby, Edward G.; Mcfall-Ngai, Margaret
  作者单位：University of Hawaii System; University of Hawaii Manoa; California Institute of Technology; University of Wisconsin System; University of Wisconsin Madison; Loyola University Chicago
  摘要：Bacterial outer membrane vesicles (OMVs) and the cargo they carry are increasingly recognized as a means of communication between microbial symbionts and the cells of their host. However, few studies have focused on the biochemical and molecular mechanisms underlying OMV signaling during symbiosis onset and development. We show here that SypC, an OMV protein of the bioluminescent symbiont Vibrio fischeri, is taken up by cells of the squid host Euprymna scolopes where it assumes a new function,...
• Identification and characterization of a wet adhesive protein extracted from Dreissena bugensis, the freshwater quagga mussel AI翻译
  作者：Obille, Angelico R.; Hasan, Rida; Rees, David J.; Ng, Judith; Wang, Zhi Yi; Bagchi, Raunaq; Lian, Keryn; Carneiro, Karina M. M.; Sone, Eli D.
  作者单位：University of Toronto; University of Toronto; University of Toronto
  摘要：Mechanisms of wet adhesion have evolved in several aquatic organisms over millions of years. Yet, the repertoire of synthetic biocompatible wet adhesive materials is still limited. The byssus is a well-studied proteinaceous bioadhesive structure utilized by several bivalves to support sessile lifestyles in turbulent conditions. The quagga mussel (Dreissena bugensis) is a freshwater byssate and a notorious invasive species in the Great Lakes region. To identify adhesive proteins in the quagga m...
• Reducing PTSD symptoms through unconscious intervention AI翻译
  作者：Yang, Qing; Wang, Yingying; Liu, Chunyu; Zhi, Pu; Chen, Siyu; Lei, Yangyang; Xue, Fei; Zhu, Zijian
  作者单位：Shaanxi Normal University; Zhejiang University; State University of New York (SUNY) System; SUNY Upstate Medical University
  摘要：Intrusive traumatic memories are a hallmark symptom of posttraumatic stress disorder (PTSD). Conventional therapies typically require explicit and emotionally distressing reexposure to trauma cues, often leading to high dropout rates among severely affected patients. This study examined whether trauma memory intrusions could be effectively reduced through unconscious intervention, minimizing emotional distress by subliminally presenting trauma-related visual cues during bilateral eye movement ...
• High-latitude teleconnections drive subtropical marine bioproductivity at the dawn of the Antarctic ice sheet AI翻译
  作者：Villa, Alexandra; Meyers, Stephen R.
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Bremen
  摘要：The inception of the Antarctic ice sheet (AIS) marked a major global climatic reorganization of the Cenozoic, but the response of the subtropical marine biosphere remains poorly constrained. A new sediment archive from the subtropical South Atlantic (IODP Exp. 390 and 393) reveals a sevenfold increase in surface ocean bioproductivity proxy accumulation (biogenic barium) commensurate with the initial expansion of the AIS 34 Mya, and the emergence of an amplified astronomical forcing of subtropi...
• A wireless sweat sensing with a pH- based correlation model for continuous glucose monitoring and diabetes management during exercise AI翻译
  作者：Zhang, Yingying; Zhang, Senhao; Yang, Ying; Tao, Lin; Yu, Fengfei; Song, Chaoyun; Guo, Kai; Zhu, Jia; Lin, Yuan; Yang, Furong; Yang, Hongbo; Cheng, Huanyu
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Suzhou Institute of Biomedical Engineering & Technology, CAS; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of London; King's College London; University of Electronic Science & Technology of China
  摘要：In situ monitoring of sweat glucose during exercise can provide a real- time and continuous assessment of blood glucose dynamics. However, the relatively poor correlation between sweat and blood glucose concentrations during exercise makes it challenging for blood glucose management (BGM) during exercise therapy for diabetes, along with training for athletes and fitness enthusiasts. This work presents a flexible wireless sweat glucose and pH sensing platform integrated with a pH- based correla...
• The quasi-liquid layer thickness controls clathrate hydrates' growth rate AI翻译
  作者：Cai, Xinrui; Salvalaglio, Matteo; Striolo, Alberto
  作者单位：University of London; University College London; University of Oklahoma System; University of Oklahoma - Norman; University of Oklahoma System; University of Oklahoma - Norman
  摘要：separations, and other applications. However, their slow growth kinetics prevents the cost-effective realization of hydrate-based technologies. To overcome this challenge, chemical additives have been identified to control hydrates' growth rate. Among others, are both effective at low concentrations. While SDS is widely available but raises environmental concerns, TRP is environmentally benign. Although both SDS and TRP are interfacially active, the molecular mechanism responsible for their ab...