24期

最新文章

• Female dolphins use individual vocal labels to track coercive males AI翻译
  作者：Bouchard, Alice; Allen, Simon J.; Sorensen, Pernille M.; Krutzen, Michael; Marfurt, Svenja M.; Connor, Richard C.; King, Stephanie L.
  作者单位：University of Bristol; University of Zurich; University of Western Australia; Aarhus University; State University System of Florida; Florida International University; State University System of Florida; Florida International University
  摘要：Animals rely on identity signaling to navigate social relationships, assess potential mates, and avoid costly interactions. While species- and group-level recognition signals can provide fitness advantages by preventing inbreeding depression and hybridization, our understanding of the role that individual identity signals can play in mate choice is notably lacking. In species with coercive mating systems, females must carefully evaluate male behavior to minimize risks while also maximizing rep...
• Glycosylation-independent functions for distinct glypican core proteins drive cell-specific responses in corticogenesis AI翻译
  作者：Douceau, Sara; Guerrero, Tanya Deutsch; Borowski, Chloe; Lourenco, Chloe; Weber, Margot; Kavaliova, Hanna; Brault, Emma; Pons, Camille; Roumier, Anne; Wild, Rebekka; Ferent, Julien
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); CEA; Communaute Universite Grenoble Alpes; CNRS - National Institute for Biology (INSB); Universite Grenoble Alpes (UGA)
  摘要：The extracellular matrix plays critical roles in orchestrating cell communication and behaviors in response to various extracellular signals. It is a complex network composed of proteins and polysaccharides, whose individual and synergistic roles in cellular signaling, structural integrity, and tissue homeostasis remain active areas of investigation. Here, we find that in the developing cerebral cortex, distinct glypicans, which are heparan sulfate proteoglycans, present very precise and compl...
• Nf2 orchestrates β-arrestin2-biased PTH1R signaling to couple bone mass with skeletal integrity AI翻译
  作者：Liao, Junguang; He, Yiliang; Zhang, Chenyang; Qian, Qitao; Huang, Yuping; Zhang, Qi; Shen, Panpan; Zhou, Chenhe; Wu, Mengrui; Chen, Guiqian
  作者单位：Zhejiang Sci-Tech University; Zhejiang University; Zhejiang University
  摘要：Precise spatiotemporal regulation of parathyroid hormone (PTH) and PTH-related peptide signaling through the parathyroid hormone receptor 1 (PTH1R) is fundamental to skeletal development and metabolic bone remodeling, yet the intracellular mechanisms that fine-tune this signaling remain a central unanswered question. Here, we identify neurofibromin 2 (Nf2) as an essential regulator of PTH1R trafficking and signaling. Conditional knockout of Nf2 in chondrocytes results in short-limbed dwarfism,...
• Social immunity can be a consequence and cause of social evolution AI翻译
  作者：Liu, Ming; Scott, Thomas W.; Shillcock, George; Pull, Christopher D.; West, Stuart A.
  作者单位：University of Oxford; University of Oxford
  摘要：Many social insects respond to pathogens in ways that reduce pathogen transmission within their social groups, with behaviors such as grooming or removing infected individuals. This social immunity within a group has been compared to the immune response of multicellular organisms. However, we lack a theoretical framework for understanding both the possible evolutionary origins and consequences of social immunity. How restrictive are the conditions for the initial evolution of social immunity? ...
• Cryopreservation through vitrification enables functional recovery of the mouse hippocampus AI翻译
  作者：Maya-Romero, Alex; Zoncu, Roberto
  作者单位：University of California System; University of California Berkeley
• mRNA delivery of a class 1/4 SARS-CoV-2 neutralizing antibody protects against diverse sarbecoviruses in a lethal mouse challenge model AI翻译
  作者：Skelly, Ashwin N.; Fan, Chengcheng; Keeffe, Jennifer R.; Okten, Arya B.; Gavor, Edem; Newby, Maddy L.; Allen, Joel D.; Kreider, Edward F.; Ding, Wenge; Osbaldeston, Rebecca A.; Park, Younghoon; Connell, Andrew J.; Lituchy, Melinda G.; Bibollet-Ruche, Frederic; Radford, Katelyn M.; West, Anthony P.; Pena-Hernandez, Mario A.; Cruickshank, Kendra; Liu, Weimin; Li, Yingying; Albertus, Amie; McWilliams, Brieyanna; Russell, Ronnie M.; Konrath, Kylie M.; Torres, Jonathan L.; Yuan, Meng; Gao, Hongmei; Montefiori, David C.; Saag, Michael S.; Goepfert, Paul A.; Kulp, Daniel W.; Ward, Andrew B.; Wilson, Ian A.; Shaw, George M.; Andrabi, Raiees; Crispin, Max; Weissman, Drew; Wilen, Craig B.; Bjorkman, Pamela J.; Hahn, Beatrice H.
  作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; California Institute of Technology; Yale University; Yale University; University of Southampton; The Wistar Institute; Scripps Research Institute; Duke University; Duke University; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham
  摘要：The unyielding antigenic drift of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as the threat of future zoonotic sarbecovirus spillovers, has prompted the search for broadly neutralizing antibodies (bNAbs) to inform rational therapeutic and vaccine design. Here, we isolated and characterized 20 receptor binding domain (RBD)-directed bNAb lineages from a serially sampled SARS-CoV-2 patient who was infected and vaccinated during the early months of the pandemic. Thirteen ...
• General inverse-cube thickness scaling of projectile penetration energy in ultrathin films AI翻译
  作者：Zaccone, Alessio; Sirk, Timothy W.
  作者单位：University of Milan
  摘要：Ultrathin films of widely different materials exhibit a dramatic enhancement of projectile penetration resistance under high-velocity impact. Despite extensive simulations and experiments, a unifying physical explanation has remained elusive. Here we show that the specific penetration energy follows a general inverse-cube scaling law, Ep & lowast;(h)=Ep,infinity & lowast;+Bh-3, across chemically and structurally distinct systems. The inverse-cube scaling is traced to a finite-size correction t...
• Tuning bubble coalescence rates over orders of magnitude in liquid mixtures of simple surface thermodynamics: Experiments and theory AI翻译
  作者：Combrouze, Ange; Choudhury, Anjishnu; Klimenko, Alexandra; Panizza, Pascal; Duchemin, Laurent; Lequeux, Francois; Verneuil, Emilie; Talini, Laurence
  作者单位：Sorbonne Universite; Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay; Universite de Rennes; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Universite Paris Cite; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS)
  摘要：The coalescence time of bubbles in a liquid depends on the nature of the liquid, which determines both its surface thermodynamics and the molecular interactions between the gas/liquid interfaces, and on the geometry, prescribed by the curvature of the bubbles. Coalescence is well described in pure liquids that have the same composition in bulk and at interfaces and in which the interactions are attractive. In contrast, the mechanisms are poorly understood in more complex liquids in which coale...
• Madhav Gadgil (1942-2026): A pioneering Indian ecologist's legacy of biodiversity conservation and human coexistence AI翻译
  作者：Kunte, Krushnamegh; Ghate, Utkarsh; Subramanian, K. A.
  作者单位：Tata Institute of Fundamental Research (TIFR); National Centre for Biological Sciences (NCBS); Zoological survey of India
  摘要：Madhav Gadgil was an evolutionary ecologist and champion of governmental and intergovernmental policies for biodiversity conservation, human coexistence with nature, and indigenous rights to land, natural resources, and self-governance. He made foundational contributions to the development of biodiversity sciences, human ecology, people's traditional knowledge-and inherent rights to that knowledge as documented through biodiversity registers. Gadgil advocated a coherent policy integrating huma...
• G-protein regulatory network governs receptor internalization dynamics AI翻译
  作者：Rowe, Jacob B.; Pandey, Shubhi; Mayer, Ryan A.; Ludlam, W. Grant; Drube, Julia; Inoue, Asuka; Hoffmann, Carsten; Martemyanov, Kirill A.
  作者单位：University of Miami; State University System of Florida; University of Florida; Friedrich Schiller University of Jena; Tohoku University; Kyoto University
  摘要：G protein-coupled receptors (GPCRs) enable chemical communication between cells and are involved in nearly all essential functions. They transduce signals via heterotrimeric G proteins and are regulated by internalization, a process which redirects them from the cell surface to internal compartments and enables diversified signaling through spatial reorganization. Beyond the receptor, a vast regulatory network exists to further control G-protein signaling. However, it is unclear whether these ...