-
作者：Hao, Xiyang; Holyoak, Marcel; Zhang, Zhicheng; Yan, Chuan
作者单位：Lanzhou University; University of California System; University of California Davis
摘要：There is global consensus on the need to prioritize conservation efforts to prevent biodiversity loss and defaunation. Most current conservation initiatives focus on areas with high species diversity or many threatened species, treating species independently and neglecting trophic interactions. To address these oversights, we developed a framework to quantify species' roles along continuums of trophic importance (TI) and global endangerment (GE), estimated from a global terrestrial meta-food w...
-
作者：Kuyyamudi, Chandrashekar; Ghosh, Suhrid; Extavour, Cassandra G.
作者单位：Harvard University; Howard Hughes Medical Institute; Harvard University
摘要：Cell migration across epithelial barriers occurs in diverse developmental, immunological, and pathological contexts. Here, we investigate the contribution of heterotypic adhesion between migrating cells and epithelial substrate cells to transepithelial migration. Using an in silico model inspired by the migration of primordial germ cells across the midgut epithelium in the Drosophila embryo, we show that heterotypic adhesion modulates migration efficiency in a nonmonotonic manner, revealing th...
-
作者：Ribardo, Deborah A.; Singh, Nanki K.; Beeby, Morgan; Hendrixson, David R.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; Imperial College London
摘要：Campylobacter jejuni is an intestinal commensal of birds and animals and a leading cause of bacterial diarrheal disease in humans. In hosts, C. jejuni primarily resides in the mucus layer atop the lower intestinal epithelium. Persistence in this niche requires a single flagellar motor at both C. jejuni poles that generates high torque for flagellar rotation to facilitate motility and high swimming velocities. Unlike many bacterial flagellates, C. jejuni swimming velocity increases as external ...
-
作者：Su, Qi; Yang, Yichun; Ren, Jiayan; Zhang, Yu; Fu, Lijuan; Wu, Qing; Han, Xu; Zhang, Yanmin
作者单位：Xi'an Jiaotong University
摘要：Tumor hypoxia promotes dedifferentiation and metabolic reprogramming in hepatocellular carcinoma (HCC), undermining normal liver functions. Here, we identify the E3 ubiquitin ligase RNF126 as a hypoxia-inducible peroxisomal fate switch that links the hypoxic microenvironment to loss of hepatocyte differentiation. Under hypoxia, HIF-2 alpha drives RNF126 expression, which in turn ubiquitinates the peroxisomal membrane transporter ABCD3, triggering selective peroxisome autophagy (pexophagy) and ...
-
作者：Wang, Zhuqing; Yamauchi, Yasuhiro; Chen, Sheng; Zheng, Huili; Ward, Monika A.; Yan, Wei
作者单位：Washington State University; University of California System; University of California Los Angeles; University of Hawaii System; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center
摘要：Paternal epigenetic inheritance remains mechanistically unresolved. Recent studies propose that environmental exposures induce mitochondrial DNA (mtDNA)-dependent transcription in sperm during epididymal transit, altering small RNA content and offspring phenotypes. Here, we show that mature murine sperm are effectively devoid of mtDNA, precluding mtDNA-dependent transcription, and that sperm-borne mitochondrial RNAs originate during spermatogenesis. Testicular sperm transmitted diet-induced me...
-
作者：Braun, Thomas; Reber, Viviane; Tiberi, Cinzia; Frankl, Andri; Ghosh, Dhiman; Riek, Roland; Serdiuk, Tetiana
作者单位：University of Basel; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Basel; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：alpha-synuclein (alpha-syn) aggregation is a hallmark of synucleinopathies, a class of neurodegenerative disorders such as Parkinson's disease (PD). Several lines of evidence indicate the involvement of mitochondria in the disease pathology. Despite extensive study, the link between alpha-syn aggregation and mechanisms of mitochondrial toxicity remains not fully understood. Using high-resolution imaging with electron microscopy, we examined SH-SY5Y cells exposed to alpha-syn fibrils vs control...
-
作者：Matt, Ann-Sophie; Tetzlaff, Smilla; Jonusaite, Sima; Quijada-Rodriguez, Alex; Schewe, Marcus; Cordeiro, Sonke; Weihrauch, Dirk; Hu, Marian Y.
作者单位：University of Kiel; University of Tulsa; Wilfrid Laurier University; University of Manitoba
摘要：Many marine organisms generate biominerals by endocytotic uptake of seawater which is modified within calcifying cells to produce an amorphous mineral precursor required to form the mineralized shell or skeleton. In this process, water must be removed from the endocytotic vesicles and the cell to promote concentration of calcification substrates and production of a water-free mineral. Here, we demonstrate that in the sea urchin larva, an aquaglyceroporin (spAQP9) is involved in the cellular ca...
-
作者：Pires, Joel P.; Tome, Diogo; Mele, Miranda; Caulino-Rocha, Ana; Corti, Elisa; Milosevic, Ira; Baltazar, Graca F.; Almeida, Ramiro D.
作者单位：Universidade de Coimbra; Universidade de Coimbra; Universidade da Beira Interior; Universidade da Beira Interior; Universidade de Aveiro; Universidade de Coimbra; Universidade de Coimbra; Universidade de Coimbra; Universidade de Coimbra; University of Oxford; Wellcome Centre for Human Genetics
摘要：Striatal-Enriched Protein Tyrosine Phosphatase (STEP) constrains synaptic potentiation by dephosphorylating postsynaptic substrates, but its presynaptic role has remained unclear. Here, we identify a previously unrecognized function of STEP in regulating axonal differentiation and synapse assembly. Genetic and pharmacological manipulation of STEP in vivo and in vitro show that STEP limits presynaptic maturation by restricting synaptic vesicle protein clustering along developing hippocampal axo...
-
作者：Taranenko, Dmitry; Kotovskaya, Oksana; Kuznedelov, Konstantin; Yanovskaya, Daria; Demkina, Alina; Fardeeva, Sofya; Mamontov, Viktor; Vierra, Kaiya; Burman, Nathaniel; Li, Dan; Wang, Minggui; Wiedenheft, Blake; Severinov, Konstantin; Semenova, Ekaterina; Isaev, Artem
作者单位：Skolkovo Institute of Science & Technology; Rutgers University System; Rutgers University New Brunswick; Russian Academy of Sciences; Pushchino Scientific Center for Biological Research (PSCBI) of the Russian Academy of Sciences; Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Montana State University System; Montana State University Bozeman; Fudan University; Russian Academy of Sciences; Institute of Gene Biology (IGB) of Russian Academy of Sciences
摘要：CRISPR-Cas adaptive immunity systems provide defense against mobile genetic elements and are often countered by diverse anti-CRISPR (Acr) proteins. The type IE CRISPR-Cas of Escherichia coli K12 has been a model for structural and functional studies and is a part of the species' core genome. However, this system is transcriptionally silent, which has fueled questions about its true biological function. To clarify the role of this system in defense, we carried out a census of Acr proteins in En...
-
作者：Forrest, Frances; Gonzalez-Alvarez, Eimy; Rolier, Dan Palcu; Kuo, Sharon; Skinner, Matthew; Reeves, Jonathan; DiMaggio, Erin; Hlubik, Sarah; Melaku, Sahleselasie; Ribordy, Mathilde; Wolde, Alemu Gebresilassie; Ndiema, Emmanuel; Braun, David R.
