24期

最新文章

• Hp1bp3 loss links chromatin reorganization to metabolic vulnerability in glioma AI翻译
  作者：Lozzi, Brittney; Gatesman, Taylor A.; Dasgupta, Pushan; Sardar, Debosmita; Ko, Yeunjung; Mao, Chenyu; Chen, Hsiao-Chi; Curry, Rachel N.; Choi, Dongjoo; Mohila, Carrie A.; Bondy, Melissa L.; Rao, Ganesh; Gallo, Marco; Agnihotri, Sameer; Deneen, Benjamin
  作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Stanford University; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital
  摘要：High-grade gliomas (HGGs) are aggressive brain tumors with poor prognosis, driven in part by metabolic and epigenetic adaptations. Methionine metabolism supports HGG growth by supplying S-adenosylmethionine for methylation reactions, yet how nutrient availability influences chromatin organization in HGG remains incompletely understood. Using an immunocompetent mouse model of HGG, we found that dietary methionine restriction reduced tumor proliferation, extended survival, and induced partial nu...
• Dissecting hydrogen bond energetics to answer the age-old question: How much do hydrogen bonds contribute to enzymatic catalysis? AI翻译
  作者：Pinney, Margaux M.; Liu, Corey; Herschlag, Daniel
  作者单位：Stanford Medicine; Stanford University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Stanford University; Stanford University; Stanford University
  摘要：Enzymes are fundamental to life, providing the rapid reactions and specificity needed to sustain biological processes. While we have overcome the first major challenge in understanding enzymes-identifying their reaction mechanisms-the second major challenge of quantifying the contributions of each catalytic interaction and molecular mechanism remains largely unmet. In particular, hydrogen bonds are ubiquitous in enzyme active sites, yet their quantitative contributions to enzyme catalysis have...
• Void-X: A generative void-filling model for predicting atomic packing in proteins AI翻译
  作者：Yang, Jing; Yuan, Junying; Chou, James J.
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Chinese Academy of Sciences
  摘要：Generative AI algorithms such as the transformer and diffusion models have greatly empowered de novo design of proteins capable of specifically interacting with designated structural sites on another protein. Most of these design methods employ a top-down approach, in which an overall protein shape is generated by an AI model to pack against a given structural site, followed by sequence design to optimize the interaction. Despite being trained on limited protein complex structures available in...
• Development of a robust method to derive human trophoblast stem cells from late-gestation placentas and its application to preeclampsia AI翻译
  作者：Oike, Akira; Kobayashi, Eri H.; Yamamoto, Yasuhiro; Hamada, Hirotaka; Takahashi, Sota; Shimizu, Takanori; Kitamura, Akane; Sekiya, Asato; Kobayashi, Norio; Shibata, Shun; Endo, Shun; Sato, Tetsuya; Kubota, Naoto; Kikutake, Chie; Suyama, Mikita; Arima, Takahiro; Okae, Hiroaki
  作者单位：Kumamoto University; Tohoku University; Tohoku University; Tohoku University; University of Michigan System; University of Michigan; Saitama Medical University; Kyushu University; University of California System; University of California Riverside; University of California System; University of California Riverside; Tohoku University
  摘要：Trophoblasts are multifunctional cells in the placenta and essential for normal pregnancy. Although trophoblast dysfunction can cause pregnancy complications, the underlying mechanisms remain unclear, and effective treatments are limited, partly because of the scarcity of appropriate experimental models. We previously reported the derivation of human trophoblast stem cells (hTSCs) from 1st-trimester placentas and blastocysts, providing a powerful tool to investigate human trophoblast developme...
• Telocyte-derived pentraxin 3 enables vascular pruning as a key driver in infantile hemangioma regression AI翻译
  作者：Pechtimaldjian, Lea; Jullie, Marie-Laure; Rousson, Chloe; Laanani, Faiza; Clachet, Julie; Idrissi, Yamina; Loot, Maya; Cario-Andre, Muriel; Prey, Sorilla; Taieb, Alain; Leaute-Labreze, Christine; Mathivet, Thomas; Moisan, Francois
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Bordeaux; Universite de Bordeaux; CHU Bordeaux; CHU Bordeaux; Universite de Bordeaux; Universite de Bordeaux; CHU Bordeaux
  摘要：The natural course of infantile hemangioma (IH), a benign vascular infantile tumor, is marked by the initial rapid proliferation of dystrophic capillaries, followed by a regression phase, which is either spontaneous or induced by the first line treatment propranolol. Although endothelial cells have been at the center of most studies, the role of stromal cells in this vascular remodeling has remained unclear. Telocytes, which are stromal cells that may be targeted by propranolol, are involved i...
• The Urban Pulse: Diagnosing the urbanization process as spiky, cyclical, and asynchronous AI翻译
  作者：Zhu, Zhe; Fragkias, Michail; Suh, Ji Won; McCoshan, Ella; Chen, Lelin; Song, Kexin; Kong, Juwon; Li, Tian; Seto, Karen C.
  作者单位：University of Connecticut; Boise State University; University of Victoria; Yale University; Cornell University
  摘要：Many urban indicators predominantly focus on static outcomes, failing to capture the dynamic nature of urbanization. Here, we introduce the concept of the Urban Pulse to characterize urbanization as a process of continual spatiotemporal change. Using dense time series remote sensing data, we operationalize the Urban Pulse for six cities that represent diverse development levels, economies, and geographies: Seattle, Shenzhen, Lagos, Mumbai, Dubai, and Mexico City. We then use the Urban Pulse to...
• GREM1/FGFR1-activated myofibroblasts induce immunosuppression and accelerate metastasis in high-grade serous ovarian cancer AI翻译
  作者：Li, Runrong; Huang, Xizhan; Chen, Yue; Chen, Xiaowen; Yang, Yue; Liu, Yurui; Bai, Binyi; Meng, Fanliang; Li, Yan; Ning, Yunshan
  作者单位：Southern Medical University - China; Southern Medical University - China; Southern Medical University - China; Southern Medical University - China
  摘要：Joint effect of cancer-associated fibroblasts (CAFs) and regulatory T cells (Tregs) can drive immunosuppression in high-grade serous ovarian cancer (HGSOC), thereby promoting tumor metastasis and limiting the clinical benefit of PD-1/PD-L1 blockade. However, the mechanistic crosstalk between CAFs and Tregs remains unclear. By integrating bulk RNA-seq, single-cell RNA-seq datasets, and spatial transcriptomics datasets with functional assays, we identified a population of TGF-beta 1-driven Greml...
• Reply to Wang et al.: Linking microbial metabolites and gut epithelial responses to microbiome-directed therapeutic foods AI翻译
  作者：Wang, Yi; Chang, Hao-Wei; Barratt, Michael J.; Gordon, Jeffrey I.
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
• A gustatory receptor-Akt axis couples nutrient sensing to hematopoiesis in the silkworm AI翻译
  作者：Zhang, Wenjing; Uno, Shogo; Sato, Ryoichi; Mang, Dingze
  作者单位：Hebei University; Tokyo University of Agriculture & Technology; Hebei University
  摘要：Hematopoiesis is tightly linked to an organism's metabolic state, yet the molecular sensors that convert nutrient availability into hematopoietic output remain poorly understood. Here, we identify a fructose-sensitive gustatory receptor, BmGr9, as a cell-intrinsic nutrient sensor that links circulating sugar levels to blood cell proliferation in the silkworm Bombyx mori. We show that fructose, whose concentration rises sharply after feeding, stimulates hematopoietic organ (HPO) proliferation t...
• Adaptive self-organization of global swidden forests AI翻译
  作者：Downey, Sean S.; Tverskoi, Denis; Scaggs, Shane A.; Wu, Xinyi; Syed, Zaarah; Lebowitz, Jensan; Qin, Rongjun; Thurner, Stefan
  作者单位：University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; Medical University of Vienna; The Santa Fe Institute
  摘要：Does swidden agriculture, a prototypical coupled human and natural system, exhibit a process of adaptive self-organization in which cultural practices balance environmental constraints through adaptive feedback? Here, we investigate whether quantitative signatures of adaptive self-organization can be detected in a dataset consisting of 18,000+ contiguous swidden patches in 18 remote sensing images of swidden mosaics from tropical and subtropical regions globally. We find that the distributions...