Aging drives a program of DNA methylation decay in plant organs

• 成果类型: Article
• 署名作者: Dai, Dawei; Chen, Ken; Tao, Jingwen; Williams, Ben P.
• 署名单位: University of California System; University of California Berkeley; University of California System; University of California Berkeley
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8075; 1095-9203
• DOI: 10.1126/science.adu2392
• 发表日期: 2026-01-29
• 页码: eadu2392
• 关键词: arabidopsis; genome; INFORMATION; genes; death; AGE

摘要

Plants display a wide range of life spans and aging rates. Although dynamic changes to DNA methylation are a hallmark of aging in mammals, it is unclear whether similar molecular signatures reflect rates of aging and organism life span in plants. In this work, we show that the short-lived model plant Arabidopsis thaliana exhibits a loss of epigenetic integrity during aging, which causes DNA methylation decay and the expression of transposable elements. We show that the rate of epigenetic aging can be manipulated by extending or curtailing life span and that shoot apical meristems are protected from these epigenetic changes. We demonstrate that a program of transcriptional repression suppresses DNA methylation maintenance pathways during aging and that mutants of this program display a complete absence of epigenetic decay while physical aging remains unaffected.