6789期

最新文章

• Investing in hope AI翻译
  作者：Smith, Jennie Erin
• Soaking up destructive signals AI翻译
  作者：Fedorova, Iana; Bondy-Denomy, Joseph
  作者单位：University of California System; University of California San Francisco
• A negative feedback loop between TERMINAL FLOWER1 and LEAFY protects inflorescence indeterminacy AI翻译
  作者：Huang, Tian; Hodgens, Charles; Prakash, Sandhan; Marconi, Marco; Wabnik, Krzysztof; Sozzani, Rosangela; Wagner, Doris
  作者单位：University of Pennsylvania; North Carolina State University; North Carolina State University; Universidad Politecnica de Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); Instituto Nacional Investigacion Tecnologia Agraria Alimentaria (INIA); Centro de Investigacion en Biotecnologia Genomica de Plantas (CBGP); Universidad Politecnica de Madrid
  摘要：Inflorescences of flowering plants adopt diverse genetically programmed and environmentally tuned architectures. By contrast, continued maintenance of the stem cell pool within the apical meristem is unresponsive to environmental cues. Through a combination of modeling and experimentation in Arabidopsis, we reveal a negative feedback loop that buffers environmental signals. This loop comprises the determinacy-promoting pioneer transcription factor LEAFY (LFY) and the indeterminacy-promoting tr...
• Community health project in Kenya and Uganda dramatically cuts new HIV infections:Large-scale study finds that simplifying delivery of prevention medication and improving connections to clinics is key AI翻译
  作者：Cohen, Jon
• Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration AI翻译
  作者：Singla, Mamta; Wang, Yu Xin; Monti, Elena; Bedi, Yudhishtar; Agarwal, Pranay; Su, Shiqi; Ancel, Sara; Hermsmeier, Maiko; Devisetti, Nitya; Pandey, Akshay; Bakooshli, Mohsen Afshar; Palla, Adelaida R.; Goodman, Stuart; Blau, Helen M.; Bhutani, Nidhi
  作者单位：Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Sanford Burnham Prebys Medical Discovery Institute; Sanford Burnham Prebys Medical Discovery Institute
  摘要：Aging or injury to the joints can lead to cartilage degeneration and osteoarthritis (OA), for which there are limited effective treatments. We found that expression of 15-hydroxy prostaglandin dehydrogenase (15-PGDH) is increased in the articular cartilage of aged or injured mice. Both systemic and local inhibition of 15-PGDH with a small-molecule inhibitor (PGDHi) led to regeneration of articular cartilage and reduction in OA-associated pain. Using single-cell RNA-sequencing and multiplexed i...
• Climate change will increase forest disturbances in Europe throughout the 21st century AI翻译
  作者：Grunig, Marc; Rammer, Werner; Senf, Cornelius; Albrich, Katharina; Andre, Frederic; Augustynczik, Andrey L. D.; Baumann, Martin; Bohn, Friedrich J.; Bouwman, Meike; Bugmann, Harald; Collalti, Alessio; Cristal, Irina; Dalmonech, Daniela; De Coligny, Francois; Dobor, Laura; Dollinger, Christina; Espelta, Josep Maria; Forrester, David I.; Garcia-Gonzalo, Jordi; Gonzalez-Olabarria, Jose Ramon; Hiltner, Ulrike; Hlasny, Tomas; Honkaniemi, Juha; Huber, Nica; Jonard, Mathieu; Jonsson, Anna Maria; Kunstler, Georges; Lagergren, Fredrik; Lindner, Marcus; Mina, Marco; Moos, Christine; Morin, Xavier; Muys, Bart; Nabuurs, Gert-Jan; Nieberg, Mats; Patacca, Marco; Peltoniemi, Mikko; Reyer, Christopher P. O.; Schelhaas, Mart-Jan; Storms, Ilie; Thom, Dominik; Toigo, Maude; Seidl, Rupert
  作者单位：Technical University of Munich; University of Basel; Swiss Tropical & Public Health Institute; University of Basel; Technical University of Munich; Natural Resources Institute Finland (Luke); University of Eastern Finland; International Institute for Applied Systems Analysis (IIASA); Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Wageningen University & Research; Swiss Federal Institutes of Technology Domain; ETH Zurich; Consiglio Nazionale delle Ricerche (CNR); Istituto per i Sistemi Agricoli e Forestali del Mediterraneo (ISAFoM-CNR); National Biodiversity Future Center; Universitat de Girona; Institut de Recherche pour le Developpement (IRD); INRAE; CIRAD; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Czech University of Life Sciences Prague; Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Commonwealth Scientific & Industrial Research Organisation (CSIRO); CSIRO Environment; Swiss Ornithological Institute; Lund University; INRAE; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); European Academy of Bozen-Bolzano; Institut de Recherche pour le Developpement (IRD); Universite PSL; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Ecole Pratique des Hautes Etudes (EPHE); KU Leuven; Wageningen University & Research; Potsdam Institut fur Klimafolgenforschung; University of Vermont; Universite de Bordeaux; INRAE
  摘要：Wildfires, insect outbreaks, and storms cause large pulses of tree mortality. Climate change amplifies these forest disturbances, yet their future magnitude and extent remain uncertain. Here, we simulated future forest disturbance regimes at 100-meter resolution across Europe using a deep learning-based simulation framework. Our results show that forest disturbances will continue to increase throughout the 21st century, with disturbed areas more than doubling relative to the recent past under ...
• Repeated convergent evolution of bradykinin mimics as defensive toxins AI翻译
  作者：Shi, Naiqi; Touchard, Axel; Schendel, Vanessa; Koch, Thomas Lund; Starobova, Hana; Niu, Pancong; Tran, Hue; Ragnarsson, Lotten; Safavi-Hemami, Helena; Vetter, Irina; Robinson, Samuel D.
  作者单位：University of Queensland; Centre National de la Recherche Scientifique (CNRS); University of Copenhagen; Utah System of Higher Education; University of Utah; University of Queensland
  摘要：Natural selection can drive the evolution of similar traits through convergent evolution. Short peptides identical to the vertebrate hormone bradykinin (BK) have been reported from the venoms and skin secretions of certain species of wasps (order Hymenoptera) and frogs (order Anura), respectively. In this study, we demonstrate that the genes encoding the BK-like peptides of hymenopteran venoms and anuran skin secretions do not share common ancestry with that of the vertebrate hormone but inste...
• US research agency moves to restrict foreign scientists Proposed rule at National Institute of Standards and Technology would limit lab access to a few years AI翻译
  作者：Service, Robert F.
• Irregular hierarchical-porous polymer for high-performance soft thermoelectrics AI翻译
  作者：Zhang, Xiao; Wang, Dongyang; Liu, Liyao; Li, Zhiyi; Ji, Zhen; Zhang, Xuefeng; Xu, Chunlin; Yan, Chaoyi; Wang, Min; Di, Yuqiu; Niu, Lixin; Zhan, Zepang; Zhao, Yue; Dai, Xiaojuan; Guan, Yong; Guan, Bo; Li, Cheng; Zou, Ye; Wang, Dong; Zhang, Fengjiao; Zhang, Deqing; Zhu, Daoben; Di, Chong-an
  作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Tsinghua University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Institute of Chemistry, CAS; Sun Yat Sen University
  摘要：Polymer thermoelectrics offer an inherently soft, cost-effective, and lightweight solution to convert ubiquitous heat sources into sustainable electricity. However, their realistic applications are hindered by insufficient performance and the scaling complexity. We introduce irregular hierarchical-porous thermoelectric polymers, featuring irregularly shaped and distributed pores with diameters that range from less than 10 nanometers to micrometers. This porous structure not only enhances multi...
• Chinese institution rejects pricey open-access fees AI翻译
  作者：Brainard, Jeffrey