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最新文章

• Support communities to conserve the Third Pole AI翻译
  作者：Fu, Yao; Yang, Xuefei; Liu, Yi; Broome, Neema Pathak; Inta, Angkhana; Puro, Neizo; Ranjitkar, Sailesh; Ali, Maroof; Liu, Haiou; Shi, Yinxian; Yang, Lixin
  作者单位：Chinese Academy of Sciences; Kunming Institute of Botany, CAS; Chiang Mai University; Nagaland University; Chinese Academy of Sciences; Xishuangbanna Tropical Botanical Garden, CAS; Chinese Research Academy of Environmental Sciences
• A small polymerase ribozyme that can synthesize itself and its complementary strand AI翻译
  作者：Gianni, Edoardo; Kwok, Samantha L. Y.; Wan, Christopher J. K.; Goeij, Kevin; Clifton, Bryce E.; Colizzi, Enrico S.; Attwater, James; Holliger, Philipp
  作者单位：MRC Laboratory Molecular Biology; University of London; University College London
  摘要：The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural complexity impede self-replication and preclude their spontaneous emergence. Here, we describe QT45, a 45-nucleotide polymerase ribozyme, discovered from random sequence pools, that catalyzes general RNA-templated RNA synthesis using trinucleotide triphosphate (triplet) substrates in mildly alkali...
• AI and quantum now drive NSF grantmaking, officials say AI翻译
  作者：Mervis, Jeffrey
• Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2 AI翻译
  作者：Taylor, Martin S.; Chen, Maggie; Hancock, Matthew; Wranik, Maximilian; Miller, Bryant D.; O'meara, Timothy R.; Palanski, Brad A.; Ficarro, Scott B.; Groendyke, Brian J.; Xiang, Yufei; Kondo, Kazuma T.; Linde-Garelli, Karen Y.; Lee, Michelle J.; Mondal, Dibyendu; Freund, Daniel; Congreve, Samantha; Matas, Kaay; Hennink, Maximiliaan; Xibinaku, Kera; Valenstein, Max L.; van Eeuwen, Trevor; Marto, Jarrod A.; Sali, Andrej; Shi, Yi; Gray, Nathanael S.; Sabatini, David M.; Chu, Nam; Rogala, Kacper B.; Cole, Philip A.
  作者单位：Brown University; Brown University; Brown University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Stanford Medicine; Stanford University; Stanford Cancer Institute; Stanford Medicine; Stanford University; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Johns Hopkins University; Johns Hopkins Medicine; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Icahn School of Medicine at Mount Sinai; Massachusetts Institute of Technology (MIT); Whitehead Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Rockefeller University; Czech Academy of Sciences; Institute of Organic Chemistry & Biochemistry of the Czech Academy of Sciences; James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University
  摘要：The mechanistic target of rapamycin (mTOR) protein kinase forms two multiprotein complexes, mTORC1 and mTORC2, that function in distinct signaling pathways. mTORC1 is regulated by nutrients, and mTORC2 is a central node in phosphoinositide-3 kinase (PI3K) and small guanosine triphosphate Ras signaling networks commonly deregulated in cancer and diabetes. Although mTOR phosphorylates many substrates in vitro, in cells, mTORC1 and mTORC2 have high specificity: mTORC2 phosphorylates the protein k...
• Sabotaging the NSF fellowship is a blunder AI翻译
  作者：Thorp, H. Holden
• Ease the struggle of young researchers AI翻译
  作者：Atamaniuk, Vitaliy
  作者单位：Rzeszow University of Technology; University of Rzeszow
• Planting a seed AI翻译
  作者：Lopez, Gilberto
  作者单位：Arizona State University; Arizona State University-Tempe
• Democratizing climate change mitigation pathways using modernized stabilization wedges AI翻译
  作者：Johnson, Nathan; Staffell, Iain
  作者单位：Imperial College London
  摘要：Mitigating climate change requires broad societal buy-in. Integrated assessment models (IAMs) produce cost-optimal pathways, but these are complex and not easily customized to reflect individuals' preferences. Twenty years ago, the stabilization wedge framework introduced a simpler way to discuss decarbonization. Here, we modernized this framework, identifying 36 strategies, each with the potential to mitigate 4% of global emissions by 2050, and quantified their required scale of deployment. P...
• Task learning increases information redundancy of neural responses in macaque visual cortex AI翻译
  作者：Liu, Shizhao; Pletenev, Anton; Haefner, Ralf M.; Snyder, Adam C.
  作者单位：University of Rochester; University of Rochester; University of Rochester; University of Rochester; University of Rochester
  摘要：How does the brain optimize sensory information for decision-making in new tasks? One hypothesis suggests that learning reduces redundancy in neural representations to improve efficiency, whereas another, based on Bayesian inference, predicts that learning increases redundancy by distributing information across neurons. We tested these hypotheses by tracking population responses in macaque cortical area V4 as monkeys learned visual discrimination tasks. We found strong support for the Bayesian...
• Multiple chromosomal inversions modulate continuous local adaptation along a steep thermal cline AI翻译
  作者：Akopyan, Maria; Jacobs, Arne; Rick, Jessica A.; Wilder, Aryn P.; Baumann, Zofia A.; Conover, David; Baumann, Hannes; Therkildsen, Nina O.
  作者单位：Cornell University; University of California System; University of California Riverside; Cornell University; University of Glasgow; University of Arizona; University of Connecticut; University of Oregon
  摘要：Chromosomal inversions are often implicated in divergence between distinct ecotypes, but their role in maintaining continuous adaptive divergence in complex traits remains poorly understood. Using quantitative and population genetics, transcriptomics, and artificial selection experiments, we demonstrate how inversions enable clinal adaptive divergence along a steep environmental gradient despite extensive gene flow in a widely distributed marine fish. We show that three inversions are associat...