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作者：Boles, Jake; Gate, David
作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine
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作者：Qiao, Lijin; Sun, Heng; Tang, Jiping; Hernandez-Reyes, Casandra; Lace, Beatrice; Knerr, Julian; Schulze, Eija; Lee, Tak; Keller, Jean; Libourel, Cyril; Yao, Jilin; Zhao, Feiyang; Ni, Ying; Jia, Yutian; Xu, Xia; Yang, Guanghui; Zhang, Lin; Zhang, Yanli; Grosse, Robert; Tian, Changfu; Oldroyd, Giles E. D.; Delaux, Pierre-Marc; Ott, Thomas; Liang, Pengbo
作者单位：China Agricultural University; China Agricultural University; China Agricultural University; University of Freiburg; University of Freiburg; University of Freiburg; University of Cambridge; University of Cambridge; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse (EPE); Communaute d'universites et etablissements de Toulouse (Comue); China Agricultural University; Tsinghua University
摘要：Colonization of plant roots by symbionts requires substantial morphodynamic reorganization. Examples are actin-scaffolded microcompartments called infection pockets formed during root nodule symbiosis (RNS) by legumes. We demonstrate that the actin-binding formin SYFO2 is indispensable for rhizobial infection in Medicago truncatula, where it drives actin polymerization in phase-separated and symbiosis-specific nanodomains. SYFO2 also regulates symbiotically active arbuscules formed during myco...
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作者：McJeon, Haewon; Ou, Yang
作者单位：Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Peking University; Peking University
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作者：Meyer, Moritz T.; Griffiths, Howard
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Cambridge
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作者：Thompson, Valerie
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作者：Vogel, Gretchen
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作者：Normile, Dennis
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作者：Chen, Yun; Liu, Yizhou; Nguyen, Khai; Wu, Junjie; Song, Sihui; Lin, Kent; Rodrigues, Patrick F.; Du, Siling; Zhou, Charles; Xiong, Kyle; Bosch, Megan; Lin, Peter Bor-Chian; Khantakova, Darya; Wu, Shitong; Wu, May; Yuede, Carla; Holtzman, David M.; Colonna, Marco
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
摘要：Alzheimer's disease (AD) is the leading cause of dementia and is characterized by progressive amyloid accumulation followed by tau-mediated neurodegeneration. Despite advances in anti-amyloid immunotherapies, important limitations remain, highlighting the need for new therapeutic strategies. Here, we introduce anti-amyloid chimeric antigen receptors expressed in astrocytes (CAR-A) and validate their function in vitro. We show that two CAR-A designs reduce amyloid and associated pathology after...
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作者：Haendel, Melissa A.; Ahern, Ryan; Bailey, Kasie B.; Bakas, Spyridon; Barth-Jones, Daniel C.; Bohl, Alex; Bian, Jiang; Bourne, Philip E.; Boyles, Rebecca R.; Chute, Christopher G.; Cimino, James J.; Grannis, Shaun; Hartman, Terry S.; Holko, Michelle; Hotaling, Nathan A.; Housman, Dan J.; Hunter, Lawrence E.; Hurwitz, Eric; Phua, Jasmin; Kahn, Michael G.; Kuzmanovic, Dario; Lemieux, Josh; Loomba, Johanna; Madlock-Brown, Charisse R.; Mandl, Kenneth D.; Mazumder, Raja; McMurry, Julie A.; McMurry, Andrew J.; Modi, Zubin J.; Moffitt, Richard A.; Mosa, Abu S. M.; Messina, Nicholas; O'Neil, Shawn T.; Peterson, Josh F.; Pfaff, Emily R.; Phuong, Jimmy; Presskreischer, Rachel; Sanders, Lee; Sarker, Abeed; Thomson, Alastair; Unertl, Kim M.; Walden, Anita; Weinstein, Jim
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Indiana University System; Indiana University Bloomington; Mathematica; Regenstrief Institute Inc; University of Virginia; Johns Hopkins University; University of Alabama System; University of Alabama Birmingham; University of Chicago; University of Colorado System; University of Colorado Anschutz; University of Southern California; University of Iowa; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; George Washington University; University of Michigan System; University of Michigan; Emory University; Vanderbilt University; University of Washington; University of Washington Seattle; Stanford University; Microsoft
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作者：Tal, Nitzan; Hadary, Romi; Chang, Renee B.; Osterman, Ilya; Jacobson, Roy; Yirmiya, Erez; Bechon, Nathalie; Hochhauser, Dina; Lopez Rivera, Miguel; Madhala, Barak; Garb, Jeremy; Goldsmith, Moshe; Wein, Tanita; Kranzusch, Philip J.; Amitai, Gil; Sorek, Rotem
作者单位：Weizmann Institute of Science; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：Immune systems in animals, plants, and bacteria often rely on intracellular nucleotide signaling, which viruses can block by sequestering or degrading these signals. We identified structural and biophysical traits shared by diverse viral antidefense proteins and used these traits to develop a computational pipeline that predicts phage proteins whose role is to manipulate bacterial immune signaling. Experimental validation revealed three previously uncharacterized protein families-Sequestin, Lo...
