作者：Cai, Liping; Zhang, Qing; Yao, Tianxiong; Zou, Xiaoxiao; Xie, Lei; Yang, Siyu; Xiao, Yanyuan; Huang, Fei; Peng, Zhiwei; Yang, Jiawen; Huang, Jianzhen; Jing, Qiqi; Ling, Ziqi; Zheng, Min; Qiao, Chuanmin; Wu, Jinyuan; Chen, Jiaqi; Jiang, Tao; Liu, Qin; Liu, Min; Chen, Zhe; Li, Jingquan; Jiang, Hui; Jiang, Haoyun; Chen, Zuoquan; Liao, Yaya; Huang, Yizhong; Li, Longyun; Zhou, Yunyan; Zhang, Zhou; Yin, Chao; Ye, Yu; Yang, Hui; Chen, Biao; Wang, Zhong; Gong, Huanfa; Chen, Dong; Huang, Cong; Tong, Xinkai; Zhou, Zhimin; Fu, Hao; Sun, Yingchun; Sun, Xiao; Yan, Min; Wu, Lin; Xiong, Shuqi; Wang, Yaxiang; Xie, Xinke; Zhou, Mengqing; Liu, Xiaodong; Xie, Xianhua; Wu, Fusheng; Liu, Zifeng; Ge, Mei; Xiong, Sanya; Li, Chenyu; Shen, Tao; Liu, Yuxin; Tang, Xi; Chang, Xiaolong; Liu, Siyi; Yu, Chuangang; Yu, Naixiang; Hu, Zikang; Cui, Dengshuai; Zhong, Jiahong; Liu, Sha; Hu, Jianchao; Wen, Yang; Zhou, Weiwei; Wei, Guanyue; Lin, Shiyao; Xiahou, Yiwen; Chen, Liqing; Li, Jianjun; Liu, Ruirong; Chen, Xiaoyun; Shu, Yujie; Chen, Feng; Wei, Chao; Hu, Xiaofen; Li, Yong; Hou, Yong; Zeng, Qingjie; Gao, Jun; Su, Ying; Li, Jing; Ma, Junwu; Guo, Yuanmei; Chen, Congying; Xiao, Shijun; Ai, Huashui; Zhang, Zhiyan; Liu, Weiwei; Yang, Qiang; Xing, Yuyun; Rao, Lin; Yang, Bin; Huang, Lusheng
作者单位：Jiangxi Agricultural University; Ministry of Science and Technology, China
摘要：Although massive cell atlases are already available, it is still a challenge to obtain an atlas of all tissues within a single body, especially in fetuses and pregnant mothers. We present a transcriptomic atlas of 2.56 million single cells covering 115 and 119 tissues from one fetal pig and its pregnant mother, respectively. We found that a cluster of heart capillary endothelial cells with enhanced fatty acid transit capability was enriched for pregnancy but restored after gestation. We also d...
作者：Cowley, Christopher J.; Sajjath, Sairaj M.; Soto-Ugaldi, Luis F.; Steiger, Mara; Larsen, Samantha B.; Carroll, Thomas; Barrows, Douglas; Mattei, Alexandra; Gonzales, Kevin A. U.; Wang, Wei; Li, Kevin; Meissner, Alexander; Kretzmer, Helene; Pe'er, Dana; Fuchs, Elaine
作者单位：Howard Hughes Medical Institute; Rockefeller University; Memorial Sloan Kettering Cancer Center; Howard Hughes Medical Institute; University of Potsdam; Max Planck Society; Rockefeller University; Memorial Sloan Kettering Cancer Center; Vertex Pharmaceuticals
摘要：Tissues harbor memories of inflammation, which heighten sensitivity to diverse future assaults. Whether and how these adaptations are sustained through time and cell division remain poorly understood. We show that in mice, epidermal stem cells store lifelong, functional epigenetic records of psoriasis-like skin flares. Applying deep learning to investigate these chromatin dynamics, we unearth CpG dinucleotide density as a major driver of memory persistence. Although unnecessary for inflammatio...
作者：Cheng, Myra; Lee, Cinoo; Khadpe, Pranav; Yu, Sunny; Han, Dyllan; Jurafsky, Dan
作者单位：Stanford University; Stanford University; Carnegie Mellon University
摘要：Despite rising concerns about sycophancy-excessive agreement or flattery from artificial intelligence (AI) systems-little is known about its prevalence or consequences. We show that sycophancy is widespread and harmful. Across 11 state-of-the-art models, AI affirmed users' actions 49% more often than humans, even when queries involved deception, illegality, or other harms. In three preregistered experiments (N = 2405), even a single interaction with sycophantic AI reduced participants' willing...
作者：Zakeri, M. Javad; Perez-Leija, Armando; Blanco-Redondo, Andrea
作者单位：State University System of Florida; University of Central Florida; Saint Louis University
摘要：The generation and manipulation of high-dimensional quantum states lies at the heart of modern quantum computation. The use of topology to resiliently encode and transport quantum information has been widely investigated in condensed matter and has recently penetrated quantum photonics. However, a route to scale up to a large number of entangled topological photonic modes has been missing. In this work, we demonstrate a method to generate high-dimensional topological photonic entanglement. Our...
作者：Blot, Guillaume; Sapieha, Przemyslaw
作者单位：Universite de Montreal; Universite de Montreal
摘要：Inflammation is transient, but its consequences can be lifelong. Even brief episodes of inflammation can lead to long-lasting changes in chromatin that control gene expression. These changes can poise cells to respond differently to subsequent inflammation episodes. For example, an initial encounter with environmental stressors, such as bacteria, viruses, or Western diets, durably tunes innate immune responses to later (related or unrelated) challenges (1, 2). These mechanisms also exist in no...
作者：Gomes, Claudio M.; Vendruscolo, Michele
作者单位：BIOISI; Universidade de Lisboa; Universidade de Lisboa; University of Cambridge
摘要：One defining feature of complex organisms is the ability to maintain protein homeostasis beyond cellular boundaries. We review how extracellular proteostasis is organized as a hierarchical network spanning pericellular, tissue, and systemic tiers. At each tier, secreted chaperones, proteases, vesicles, receptors, immune sentinels, and clearance organs cooperate to recognize, buffer, and eliminate misfolded proteins. Feedback through immune signaling, stress-induced protein secretion, and glymp...
