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作者：Hu, Hongmiao; Neumann, Hannah; Teplitz, Gabriela M.; Franco-Echevarria, Elsa; Chartrand, Pascal; Wellinger, Raymund J.; Nguyen, Thi Hoang Duong
作者单位：MRC Laboratory Molecular Biology; Universite de Montreal; University of Sherbrooke
摘要：Telomerase is a reverse transcriptase that synthesizes telomeric repeats at chromosome ends, safeguarding genome integrity. We present the cryo-electron microscopy structure of the budding yeast telomerase, which exhibits substantial divergence from its ciliate and vertebrate counterparts. The structure reveals a stable core formed by telomerase RNA TLC1; the three ever shorter telomere (Est) proteins, Est1, Est2 and Est3; and the Pop1/Pop6/Pop7 complex (Pop1/6/7). TLC1, Est3, and Pop1/6/7 ser...
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作者：Lawrence, Andy
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作者：Romey, Kristin
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作者：You, Seonju; Ladd-Parada, Marjorie; Nam, Kyeongmin; Karina, Aigerim; Lee, Seoyoung; Shin, Myeongsik; Yang, Cheolhee; Han, Yeseul; Jeong, Sangmin; Park, Kichan; Kim, Kyeongwon; Ki, Minjeong; Tyburski, Robin; Andronis, Iason; Ralf, Keely; Lee, Jae Hyuk; Eom, Intae; Kim, Minseok; Ma, Rory; Jang, Dogeun; Perakis, Fivos; Poole, Peter H.; Amann-Winkel, Katrin; Kim, Kyung Hwan; Nilsson, Anders
作者单位：Pohang University of Science & Technology (POSTECH); Stockholm University; Royal Institute of Technology; Saint Francis Xavier University - Canada; Pohang University of Science & Technology (POSTECH); Max Planck Society; Johannes Gutenberg University of Mainz
摘要：The search for the liquid-liquid critical point in supercooled water is challenging owing to rapid crystallization. We studied supercooled water at timescales before ice formation by heating high- and low-density amorphous ices using infrared ultrafast laser pulses, followed by x-ray scattering. By varying the pump laser fluence, we accessed liquid states straddling the predicted critical point. We observed a crossover from a discontinuous to a continuous transition at which broad and slow str...
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作者：Zhang, Bing; Han, Jingyan; Zhao, Yong; Liu, Jianbo; Chang, Huanyu
作者单位：Tianjin Normal University; Tianjin Agricultural University; China Institute of Water Resources & Hydropower Research; Tianjin Normal University
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作者：Huning, Laurie S.; Brunner, Manuela I.
作者单位：California State University System; California State University Long Beach; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research
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作者：Jadeja, Ravirajsinh
作者单位：Meharry Medical College
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作者：Grimm, David
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作者：Sepulveda, Ignacio; Nilsson, Bjarke; Yu, Yao; Carvajal, Matias; Brandin, Matthew; Gabriel, Alice-Agnes; Sandwell, David
作者单位：California State University System; San Diego State University; Technical University of Denmark; University of California System; University of California San Diego; Scripps Institution of Oceanography; Pontificia Universidad Catolica de Valparaiso; Universidad de Concepcion; University of Munich
摘要：Tsunamis from large subduction earthquakes pose severe coastal hazards, yet their genesis near the trench remains poorly constrained by land-based seismic geodetic data and distant deep-water sensors. Following the 29 July 2025 magnitude 8.8 Kamchatka earthquake, the NASA/CNES Surface Water and Ocean Topography (SWOT) satellite captured a distinct train of short-wavelength tsunami waves, which we link to near-trench tsunamigenesis. Sensitivity analyses of earthquake slip indicated tsunamigenes...
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作者：Wu, Xing; Bellagio, Tatiana; Peng, Yunru; Czech, Lucas; Lin, Meixi; Lang, Patricia; Epstein, Ruth; Abdelaziz, Mohamed; Alexander, Jake; Alonso-Blanco, Carlos; Andersen, Heidi Lie; Berbel, Modesto; Bergelson, Joy; Bossdorf, Oliver; Burghardt, Liana; Caton-Darby, Mireille; Colautti, Robert; Delker, Carolin; Dimitrakopoulos, Panayiotis G.; Donohue, Kathleen; Durka, Walter; Escribano-Avila, Gema; Franks, Steven J.; Fritschi, Felix B.; Galanidis, Alexandros; Garcia-Fernandez, Alfredo; Garcia-Munoz, Ana; Hamann, Elena; Hutt, Allison; Iriondo, Jose M.; Juenger, Thomas E.; Keller, Stephen R.; Koehl, Karin; Korte, Arthur; Korte, Pamela; Kutschera, Alexander; Lara-Romero, Carlos; Leventhal, Laura; Maag, Daniel; Marcer, Arnald; March-Salas, Marti; de Meaux, Juliette; Mendez-Vigo, Belen; Morente-Lopez, Javier; Morton, Timothy C.; Munzbergova, Zuzana; Muola, Anne; Nomoto, Hanna Akiko; Partel, Meelis; Pico, F. Xavier; Quarles-Chidyagwai, Brandie; Quint, Marcel; Reichelt, Niklas; Rudak, Agnieszka; Schmitt, Johanna; Schmitz, Gregor; Seifan, Merav; Snoek, Basten L.; Stam, Remco; Stift, Marc; Stinchcombe, John R.; Taylor, Mark A.; Tiffin, Peter; Till-Bottraud, Irene; Traveset, Anna; Valay, Jean-Gabriel; Van Zanten, Martijn; Vandvik, Vigdis; Violle, Cyrille; Weigel, Detlef; Wodkiewicz, Maciej; Vasseur, Francois; Scheepens, J. F.; Exposito-Alonso, Moises
作者单位：University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley; Carnegie Institution for Science; Stanford University; University of Granada; Swiss Federal Institutes of Technology Domain; ETH Zurich; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Nacional de Biotecnologia (CNB); University of Bergen; New York University; Eberhard Karls University of Tubingen; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California Davis; Queens University - Canada; Martin Luther University Halle Wittenberg; University of Aegean; Duke University; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Fordham University; Fordham University; University of Missouri System; University of Missouri Columbia; Universidad Rey Juan Carlos; Heinrich Heine University Dusseldorf; University of Texas System; University of Texas Austin; University of Vermont; Max Planck Society; University of Wurzburg; Technical University of Munich; Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Goethe University Frankfurt; University of Cologne; University of Chicago; Charles University Prague; Czech Academy of Sciences; Institute of Botany of the Czech Academy of Sciences; Norwegian Institute of Bioeconomy Research; University of Tartu; Tartu University Institute of Ecology & Earth Sciences; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); University of California System; University of California Davis; University of Warsaw; University of California System; University of California Davis; Ben-Gurion University of the Negev; Utrecht University; University of Kiel; University of Konstanz; University of Toronto; University of Minnesota System; University of Minnesota Twin Cities; Centre National de la Recherche Scientifique (CNRS); Universite Clermont Auvergne (UCA); Universitat de les Illes Balears; Consejo Superior de Investigaciones Cientificas (CSIC); ATTITUS Educacao; Communaute Universite Grenoble Alpes; Centre National de la Recherche Scientifique (CNRS); Universite Grenoble Alpes (UGA); Utrecht University; University of Bergen; Universite Paul-Valery; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Universite PSL; Institut Agro; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro Montpellier; Goethe University Frankfurt; University of California System; University of California Berkeley; Washington University (WUSTL); University of Copenhagen; University of California System; University of California Berkeley
摘要：Climate change forces species to adapt rapidly to avoid extinction. To directly observe rapid adaptation and extinction, we conducted synchronized evolution experiments with Arabidopsis thaliana in 30 locations across Western Europe, the Mediterranean, the Levant, and North America. Whole-genome pooled sequencing of similar to 70,000 surviving plants revealed repeatable allele frequency shifts in similar climates but divergent shifts across contrasting ones, indicating evolutionary adaptation....
