15期

最新文章

• Mid-infrared trace detection with parts-per-quadrillion quantitation accuracy: Expanding frontiers of radiocarbon sensing AI翻译
  作者：Jiang, Jun; McCartt, A. Daniel
  作者单位：United States Department of Energy (DOE); Lawrence Livermore National Laboratory
  摘要：Detection sensitivity is a critical characteristic to consider during selection of spectroscopic techniques. However, high sensitivity alone is insufficient for spectroscopic measurements in spectrally congested regions. Two-color cavity ringdown spectroscopy (2C-CRDS), based on intra-cavity pump-probe detection, simultaneously achieves high detection sensitivity and selectivity. This combination enables mid-infrared detection of radiocarbon dioxide ((CO2)-C-14) molecules in room-temperature C...
• Deletion of the TMEM30A gene enables leukemic cell evasion of NK cell cytotoxicity AI翻译
  作者：Kristenson, Linnea; Badami, Chiara; Ljungberg, Angelica; Islamagic, Erna; Tian, Yarong; Xie, Guojiang; Hussein, Brwa Ali; Pesce, Silvia; Tang, Ka- Wei; Thoren, Fredrik B.
  作者单位：University of Gothenburg; University of Gothenburg; University of Gothenburg; University of Genoa; Sahlgrenska University Hospital; University of Gothenburg
  摘要：Natural killer (NK) cell immunotherapy has gained attention as a promising strategy for treatment of various malignancies. In this study, we used a genome-wide CRISPR screen to identify genes that provide protection or susceptibility to NK cell cytotoxicity. The screen confirmed the role of several genes in NK cell regulation, such as genes involved in interferon-gamma signaling and antigen presentation, as well as genes encoding the NK cell receptor ligands B7 - H6 and CD58. Notably, the gene...
• Space wandering in the rodent default mode network AI翻译
  作者：Nghiem, Trang-Anh Estelle; Lee, Byeongwook; Chao, Tzu-Hao Harry; Branigan, Nicholas K.; Mistry, Percy K.; Shih, Yen - Yu Ian; Menon, Vinod
  作者单位：Stanford University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Stanford University; Stanford University
  摘要：The default mode network (DMN) is a large- scale brain network known to be suppressed during a wide range of cognitive tasks. However, our comprehension of its role in naturalistic and unconstrained behaviors has remained elusive because most research on the DMN has been conducted within the restrictive confines of MRI scanners. Here, we use multisite GCaMP (a genetically encoded calcium indicator) fiber photometry with simultaneous videography to probe DMN function in awake, freely exploring ...
• WNK kinase is a vasoactive chloride sensor in endothelial cells AI翻译
  作者：Garrud, Tessa A. C.; Bell, Briar; Mata-Daboin, Alejandro; Peixoto-Neves, Dieniffer; Collier, Daniel M.; Cordero-Morales, Julio F.; Jaggar, Jonathan H.
  作者单位：University of Tennessee System; University of Tennessee Health Science Center; University of Texas System; University of Texas Health Science Center Houston; University of Tennessee System; University of Tennessee Health Science Center
  摘要：Endothelial cells (ECs) line the wall of blood vessels and regulate arterial contractility to tune regional organ blood flow and systemic pressure. Chloride (Cl-) is the late EC function to alter arterial contractility is unclear. Here, we tested the hypothesis the signaling mechanisms involved, including the participation of WNK kinase. Our data obtained using two- photon microscopy and cell- specific inducible knockout mice indicated that acetylcholine, a prototypical vasodilator, stimulated...
• Complex deep-sea expeditions try to size up seabed mining impacts AI翻译
  作者：Gilbert, Natasha
• The axial skeleton of Tiktaalik roseae AI翻译
  作者：Stewart, Thomas A.; Lemberg, Justin B.; Hillan, Emily J.; Magallanes, Isaac; Daeschler, Edward B.; Shubin, Neil H.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Chicago; University of Chicago; Drexel University
  摘要：The axial columns of the earliest limbed vertebrates show distinct patterns of regionalization as compared to early tetrapodomorphs. Included among their novel features are sacral ribs, which provide linkage between the vertebral column and pelvis, contributing to body support and propulsion by the hindlimb. Data on the axial skeletons of the closest relatives of limbed vertebrates are sparce, with key features of specimens potentially covered by matrix. Therefore, it is unclear in what sequen...
• The wooden artifacts from Schöningen's Spear Horizon and their place in human evolution AI翻译
  作者：Leder, Dirk; Lehmann, Jens; Milks, Annemieke; Koddenberg, Tim; Sietz, Michael; Vogel, Matthias; Boehner, Utz; Ae, Thomas Terberger
  作者单位：University of Reading; University of Gottingen; University of Gottingen
  摘要：Ethnographic records show that wooden tools played a pivotal role in the daily lives of hunter- gatherers including food procurement tools used in hunting (e.g., spears, throwing sticks) and gathering (e.g. digging sticks, bark peelers), as well as, domestic tools (e.g., handles, vessels). However, wood rarely survives in the archeological record, especially in Pleistocene contexts and knowledge of prehistoric hunter- gatherer lifeways is strongly biased by the survivorship of more resilient m...
• DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8 (vol 121, e2310264121, 2024) AI翻译
  作者：Swarnkar, Gaurav; Semenkovich, Nicholas P.; Arra, Manoj; Mims, Dorothy K.; Naqvi, Syeda Kanwal; Peterson, Timothy; Mbalaviele, Gabriel; Wu, Chia- Lung; Abu-Amer, Yousef
• The dawn of the tropical Atlantic invasion into the Mediterranean Sea AI翻译
  作者：Albano, Paolo G.; Schultz, Lotta; Wessely, Johannes; Taviani, Marco; Dullinger, Stefan; Danise, Silvia
  作者单位：Stazione Zoologica Anton Dohrn; University of Bergen; University of Vienna; Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze Marine (ISMAR-CNR); Stazione Zoologica Anton Dohrn; University of Florence
  摘要：The Mediterranean Sea is a marine biodiversity hotspot already affected by climate- driven biodiversity collapses. Its highly endemic fauna is at further risk if global warming triggers an invasion of tropical Atlantic species. Here, we combine modern species occurrences with a unique paleorecord from the Last Interglacial (135 to 116 ka), a conservative analog of future climate, to model the future distribution of an exemplary subset of tropical West African mollusks, currently separated from...
• OASIS: An interpretable, finite-sample valid alternative to Pearson's X2 for scientific discovery AI翻译
  作者：Baharav, Tavor Z.; Tse, David; Salzman, Julia
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Stanford University; Stanford University; Stanford University; Stanford University
  摘要：Contingency tables, data represented as counts matrices, are ubiquitous across quantitative research and data-science applications. Existing statistical tests are insufficient however, as none are simultaneously computationally efficient and statistically valid for a finite number of observations. In this work, motivated by a recent application in reference-free genomic inference [K. Chaung et al., Cell 186, 5440-5456 (2023)], we develop Optimized Adaptive Statistic for Inferring Structure (OA...