15期

最新文章

• Chemically active wetting AI翻译
  作者：Liese, Susanne; Zhao, Xueping; Weber, Christoph A.; Juelicher, Frank
  作者单位：University of Augsburg; University of Augsburg; University of Nottingham Ningbo China; Max Planck Society; Technische Universitat Dresden
  摘要：Wetting of liquid droplets on passive surfaces is ubiquitous in our daily lives, and the governing physical laws are well understood. When surfaces become active, however, the governing laws of wetting remain elusive. Here, we propose chemically active wetting as a class of active systems where the surface is active due to a binding process that is maintained away from equilibrium. We derive the corresponding nonequilibrium thermodynamic theory and show that active binding fundamentally change...
• Spatial spillovers of violent conflict amplify the impacts of climate variability on malaria risk in sub-Saharan Africa AI翻译
  作者：Yu, Qiwei; Qu, Ying; Zhang, Liqiang; Yao, Xin; Yang, Jing; Chen, Siyuan; Liu, Hui; Wang, Qihao; Wu, Mengfan; Tao, Junpei; Zhou, Chenghu; Alage, Isiaka Lukman; Liu, Suhong
  作者单位：Beijing Normal University; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS
  摘要：Africa carries a disproportionately high share of the global malaria burden, accounting for 94% of malaria cases and deaths worldwide in 2019. It is also a politically unstable region and the most vulnerable continent to climate change in recent decades. Knowledge about the modifying impacts of violent conflict on climate-malaria relationships remains limited. Here, we quantify the associations between violent conflict, climate variability, and malaria risk in sub-Saharan Africa using health s...
• Pathogen prospecting of museums: Reconstructing malaria epidemiology AI翻译
  作者：Nelder, Mark P.; Schats, Rachel; Poinar, Hendrik N.; Cooke, Amanda; Brickley, Megan B.
  作者单位：Public Health Ontario; Leiden University; Leiden University - Excl LUMC; McMaster University; McMaster University; McMaster University
  摘要：Malaria is a disease of global significance. Ongoing changes to the earth's climate, antimalarial resistance, insecticide resistance, and socioeconomic decline test the resilience of malaria prevention programs. Museum insect specimens present an untapped resource for studying vector-borne pathogens, spurring the question: Do historical mosquito collections contain Plasmodium DNA, and, if so, can museum specimens be used to reconstruct the historical epidemiology of malaria? In this Perspectiv...
• Evidence of strain structure in Plasmodium falciparum var gene repertoires in children from Gabon, West Africa (Vol 114, pg E4103, 2017) AI翻译
  作者：Day, Karen P.; Artzy-Randrup, Yael; Tiedje, Kathryn E.; Rougeron, Virginie; Chen, Donald S.; Rask, Thomas S.; Rorick, Mary M.; Migot-Nabias, Florence; Deloron, Philippe; Luty, Adrian J. F.; Pascual, Mercedes
• Topological wetting states of microdroplets on closed-loop structured surfaces: Breakdown of the Gibbs equation at the microscale AI翻译
  作者：Lin, Dongdong; Wang, Shixian; Xu, Wenwu; Chen, Yuhao; Li, Pei; Fang, Ye-Guang; Zhao, Wenhui; Duan, Xiangmei; Yang, Xinju; Jiang, Zuimin; Fang, Wei-Hai; Zeng, Xiao Cheng; Francisco, Joseph S.; Gao, Yurui
  作者单位：Ningbo University; Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Fudan University; Beijing Normal University; City University of Hong Kong; University of Pennsylvania
  摘要：Microdroplets are a class of soft matter that has been extensively employed for chemical, biochemical, and industrial applications. However, fabricating microdroplets with largely controllable contact-area shape and apparent contact angle, a key prerequisite for their applications, is still a challenge. Here, by engineering a type of surface with homocentric closed-loop microwalls/microchannels, we can achieve facile size, shape, and contact-angle tunability of microdroplets on the textured su...
• Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion AI翻译
  作者：Murcia, Francisco Jose Lopez -; Lin, Kun - Han; Berns, Manon M. M.; Ranjan, Mrinalini; Lipstein, Noa; Neher, Erwin; Brose, Nils; Reim, Kerstin; Taschenberger, Holger
  作者单位：University of Gottingen; University of Gottingen; University of Barcelona; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); University of Copenhagen
  摘要：The presynaptic SNARE- complex regulator complexin (Cplx) enhances the fusogenicity of primed synaptic vesicles (SVs). Consequently, Cplx deletion impairs action potential- evoked transmitter release. Conversely, though, Cplx loss enhances spontaneous and delayed asynchronous release at certain synapse types. Using electrophysiology and kinetic modeling, we show that such seemingly contradictory transmitter release phenotypes seen upon Cplx deletion can be explained by an additional of Cplx in...
• Exotic self-assembly of hard spheres in a morphometric solvent AI翻译
  作者：Spirandelli, Ivan; Coles, Rhoslyn; Friesecke, Gero; Evans, Myfanwy E.
  作者单位：University of Potsdam; Technical University of Berlin; Technische Universitat Chemnitz; Technical University of Munich
  摘要：The self -assembly of spheres into geometric structures, under various theoretical conditions, offers valuable insights into complex self -assembly processes in soft systems. Previous studies have utilized pair potentials between spheres to assemble maximum contact clusters in simulations and experiments. The morphometric approach to solvation free energy that we utilize here goes beyond pair potentials; it is a geometrybased theory that incorporates a weighted combination of geometric measure...
• Construction of the single- diamond- structured titania scaffold- Recreation of the holy grail photonic structure AI翻译
  作者：Wang, Chao; Cui, Congcong; Deng, Quanzheng; Zhang, Chong; Asahina, Shunsuke; Cao, Yuanyuan; Mai, Yiyong; Che, Shunai; Han, Lu
  作者单位：Tongji University; Tohoku University; East China University of Science & Technology; Shanghai Jiao Tong University
  摘要：As one of the most stunning biological nanostructures, the single- diamond (SD) surface discovered in beetles and weevils exoskeletons possesses the widest complete photonic bandgap known to date and is renowned as the holy grail of photonic materials. However, the synthesis of SD is difficult due to its thermodynamical instability compared to the energetically favoured bicontinuous double diamond and other easily formed lattices; thus, the artificial fabrication of SD has long been a formidab...
• Postsynaptic receptors regulate presynaptic transmitter stability through transsynaptic bridges AI翻译
  作者：Godavarthi, Swetha K.; Hiramoto, Masaki; Ignatyev, Yuri; Levin, Jacqueline B.; Li, Hui-quan; Pratelli, Marta; Borchardt, Jennifer; Czajkowski, Cynthia; Borodinsky, Laura N.; Sweeney, Lora; Cline, Hollis T.; Spitzer, Nicholas C.
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Scripps Research Institute; Institute of Science & Technology - Austria; University of California System; University of California Davis; University of Wisconsin System; University of Wisconsin Madison
  摘要：Stable matching of neurotransmitters with their receptors is fundamental to synapse function and reliable communication in neural circuits. Presynaptic neurotransmitters regulate the stabilization of postsynaptic transmitter receptors. Whether postsynaptic receptors regulate stabilization of presynaptic transmitters has received less attention. Here, we show that blockade of endogenous postsynaptic acetylcholine receptors (AChR) at the neuromuscular junction destabilizes the cholinergic phenot...
• Transcription factor C/EBPα is required for the development of Ly6Chi monocytes but not Ly6Clo monocytes AI翻译
  作者：Kim, Sunkyung; Chen, Jing; Ou, Feiya; Liu, Tian -Tian; Jo, Suin; Gillanders, William E.; Murphy, Theresa L.; Murphy, Kenneth M.
  作者单位：Washington University (WUSTL)
  摘要：Monocytes comprise two major subsets, Ly6Chi classical monocytes and Ly6Clo nonclassical monocytes. Notch2 signaling in Ly6Chi monocytes triggers transition to Ly6Clo monocytes, which require Nr4a1, Bcl6, Irf2, and Cebpb. By comparison, less is known about transcriptional requirements for Ly6Chi monocytes. We find transcription factor CCAAT/enhancer- binding protein alpha (C/EBP alpha) is highly expressed in Ly6Chi monocytes, but down- regulated in Ly6Clo monocytes. A few previous studies desc...