2024

最新文章

• Molecular insights into the interaction between a disordered protein and a folded RNA AI翻译
  作者：Mitra, Rishav; Usher, Emery T.; Dedeoglu, Selin; Crotteau, Matthew J.; Fraser, Olivia A.; Yennawar, Neela H.; Gadkari, Varun V.; Ruotolo, Brandon T.; Holehouse, Alex S.; Salmon, Loic; Showalter, Scott A.; Bardwell, James C. A.
  作者单位：University of Michigan System; University of Michigan; Howard Hughes Medical Institute; University of Michigan System; University of Michigan; Washington University (WUSTL); Washington University (WUSTL); Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Michigan System; University of Michigan; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California San Francisco; University of Minnesota System; University of Minnesota Twin Cities; University of California System; University of California San Francisco
  摘要：Intrinsically disordered protein regions (IDRs) are well established as contributors to intermolecular interactions and the formation of biomolecular condensates. In particular, RNA- binding proteins (RBPs) often harbor IDRs in addition to folded RNA- binding domains that contribute to RBP function. To understand the dynamic interactions of an IDR-RNA complex, we characterized the RNA- binding features of a small (68 residues), positively charged IDR- containing protein, Small ERDK-Rich Factor...
• Synthesizing ordered polar patterns in nonpolar SrTiO3 nanofilms via wrinkle- induced flexoelectricity AI翻译
  作者：Shang, Hongxing; Sheng, Tang; Dong, Huiting; Wu, Yihan; Ma, Qianqian; Zhang, Xin; Lv, Lingtong; Cao, Hongyu; Deng, Feng; Liang, Xu; Hu, Shuling; Shen, Shengping
  作者单位：Xi'an Jiaotong University; Fuzhou University
  摘要：Ordered polar structures in oxide nanofilms play a pivotal role in the development of nanoelectronic applications. Hitherto, ordered polar structures have been restricted to a limited number of ferroelectric materials, and there is no effective scheme to induce and manipulate ordered polar patterns in centrosymmetric nonpolar nanofilms due to the absence of spontaneous symmetry breaking. Here, we circumvent these limitations by utilizing the wrinkle- induced strain gradient modulation associat...
• Small- molecule disruption of androgen receptor-dependent chromatin clusters AI翻译
  作者：Kohrt, Sarah E.; Novak, Emily J.; Tapadar, Subhashish; Wu, Bocheng; Strope, Jonathan; Strope, Jonathan; Asante, Yaw; Kim, Hyunmin; Chang, Matthew S.; Gurdak, Douglas; Khalil, Athar; Rood, Michael; Raftery, Eric; Stavreva, Diana; Nguyen, Holly M.; Brown, Lisha G.; Ramser, Maddy; Peer, Cody; Meyers, Warren M.; Aboreden, Nicholas; Chakravortee, Maharshi; Sallari, Richard; Nelson, Peter S.; Kelly, Kathleen K.; Graham, Thomas G. W.; Darzacq, Xavier; Figg, William D.; Oyelere, Adegboyega K.; Corey, Eva; Ogala, Remi Adelaiye --; Gryder, Berkley E.
  作者单位：University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Georgia; Georgia Institute of Technology; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University of Washington; University of Washington Seattle; University of British Columbia; University of Pennsylvania; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University of California System; University of California Berkeley; State University of New York (SUNY) System; University at Buffalo, SUNY
  摘要：Sustained androgen receptor (AR) signaling during relapse is a central driver of metastatic castration- resistant prostate cancer (mCRPC). Current AR antagonists, such as enzalutamide, fail to provide long- term benefit for the mCRPC patients who have dramatic increases in AR expression. Here, we report AR antagonists with efficacy in AR- overexpressing models. These molecules bind to the ligand- binding domain of the AR, promote AR localization to the nucleus, yet potently and selectively dow...
• The RING- type E3 ligase RIE1 sustains leaf longevity by specifically targeting AtACS7 to fine- tune ethylene production in Arabidopsis AI翻译
  作者：Tang, Xianglin; Mei, Yuanyuan; He, Kaixuan; Liu, Ran; Lv, Xiaoyan; Zhao, Yujia; Li, Wenjing; Wang, Qian; Gong, Qinshan; Li, Shengnan; Xu, Chang; Zheng, Xu; Cao, Qingyu; Wang, Dan; Wang, Ning Ning
  作者单位：Nankai University
  摘要：Ethylene is widely recognized as a positive regulator of leaf senescence. However, how plants coordinate the biosynthesis of ethylene to meet the requirements of senescence progression has not been determined. The rate- limiting enzyme in the ethylene biosynthesis pathway is ACC synthase. AtACS7 was previously considered one of the major contributors to the synthesis of senescence ethylene in Arabidopsis. However, the brake signal that fine- tunes the expression of AtACS7 to ensure optimal eth...
• Using the phenotype differences model to identify genetic effects in samples of partially genotyped sibling pairs AI翻译
  作者：Trejo, Sam; Kanopka, Klint
  作者单位：Princeton University; New York University
  摘要：The identification of causal relationships between specific genes and social, behavioral, and health outcomes is challenging due to environmental confounding from population stratification and dynastic genetic effects. Existing methods to eliminate environmental confounding leverage random genetic variation resulting from recombination and require within-family dyadic genetic data (i.e., parent-child and/or sibling pairs), meaning they can only be applied in relatively small and selected sampl...
• CD4+ T cells drive corneal nerve damage but not epitheliopathy in an acute aqueous- deficient dry eye model AI翻译
  作者：Vereertbrugghen, Alexia; Pizzano, Manuela; Cernutto, Agostina; Sabbione, Florencia; Keitelman, Irene A.; Aguilar, Douglas Vera; Podhorzer, Ariel; Fuentes, Federico; Corral-Vazquez, Celia; Guzman, Mauricio; Giordano, Mirta N.; de Paiva, Cintia S.; Downie, Laura E.; Nathans, Jeremy
  作者单位：Buenos Aires National Academy of Medicine; Buenos Aires National Academy of Medicine; Buenos Aires National Academy of Medicine; Hospital del Mar Research Institute; Hospital del Mar; Baylor College of Medicine
  摘要：Dry eye disease (DED) is characterized by a dysfunctional tear film in which the corneal epithelium and its abundant nerves are affected by ocular desiccation and inflammation. Although adaptive immunity and specifically CD4(+ )T cells play a role in DED pathogenesis, the exact contribution of these cells to corneal epithelial and neural damage remains undetermined. To address this, we explored the progression of a surgical DED model in wild- type (WT) and T cell- deficient mice. We observed t...
• Hematite U-Pb dating of Snowball Earth meltwater events AI翻译
  作者：Courtney-Davies, Liam; Flowers, Rebecca M.; Siddoway, Christine S.; Hart, Adrian Tasistro-; Macdonald, Francis A.
  作者单位：University of Colorado System; University of Colorado Boulder; Colorado College; University of California System; University of California Santa Barbara; University of California System; University of California Berkeley
  摘要：The Snowball Earth hypothesis predicts global ice cover; however, previous descriptions of Cryogenian (720-635 Ma) glacial deposits are limited to continental margins and shallow marine basins. The Tavakaiv (Tava) sandstone injectites and ridges in Colorado, USA, preserve a rare terrestrial record of Cryogenian low-latitude glaciation. Injectites, ridges, and chemically weathered crystalline rock display features characteristic of fluidization and pervasive deformation in a subglacial environm...
• Quorum sensing orchestrates parallel cell death pathways in Vibrio cholerae via Type 6 secretion- dependent and- independent mechanisms AI翻译
  作者：Mashruwala, Ameya A.; Bassler, Bonnie L.
  作者单位：Princeton University; Howard Hughes Medical Institute; Stowers Institute for Medical Research
  摘要：Quorum sensing (QS) is a cell- to- cell communication process that enables bacteria to coordinate group behaviors. In Vibrio cholerae colonies, a program of spatial- temporal cell death is among the QS- controlled traits. Cell death occurs in two phases, first along the colony rim, and subsequently, at the colony center. Both cell death phases are driven by the type 6 secretion system (T6SS). Here, we show that HapR, the master QS regulator, does not control t6ss gene expression nor T6SS- medi...
• Structural determinants of protein kinase A essential for CFTR channel activation AI翻译
  作者：Mihalyi, Csaba; Iordanov, Iordan; Szollosi, Andras; Csanady, Laszlo
  作者单位：Semmelweis University; Semmelweis University; Semmelweis University
  摘要：Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the anion channel mutated in cystic fibrosis (CF) patients, is activated by the catalytic subunit of protein kinase A (PKA-C). PKA-C activates CFTR both noncatalytically, through binding, and catalytically, through phosphorylation of multiple serines in CFTR's regulatory (R) domain. Here, we identify key molecular determinants of the CFTR/PKA-C interaction essential for these processes. By comparing CFTR current activation in the pres...
• Cryo- EM structure of the zinc- activated channel (ZAC) in the Cys- loop receptor superfamily AI翻译
  作者：Jin, Fei; Lin, Yi-Yu; Wang, Ru-Chun; Xie, Tang-Xuan; Zhao, Yimeng; Shen, Cheng; Sheng, Danqi; Ichikawa, Muneyoshi; Yu, Ye; Wang, Jin; Hattori, Motoyuki
  作者单位：Fudan University; China Pharmaceutical University; Fudan University; Fudan University; China Pharmaceutical University
  摘要：Cys-loop receptors are a large superfamily of pentameric ligand-gated ion channels with various physiological roles, especially in neurotransmission in the central nervous system. Among them, zinc- activated channel (ZAC) is a Zn2+- activated ion channel that is widely expressed in the human body and is conserved amongeukaryotes. Due to its gating by extracellular Zn2+, ZAC has been considered a Zn2+ sensor, but it has undergone minimal structural and functional characterization since its mole...