2024

最新文章

• Cross- pollination in seed- blended refuge and selection for Vip3A resistance in a lepidopteran pest as detected by genomic monitoring AI翻译
  作者：Pezzini, Daniela; Taylor, Katherine L.; Reisig, Dominic D.; Fritz, Megan L.
  作者单位：Bayer AG; Bayer CropScience; North Carolina State University; University System of Maryland; University of Maryland College Park
  摘要：The evolution of pest resistance to management tools reduces productivity and results in economic losses in agricultural systems. To slow its emergence and spread, monitoring and prevention practices are implemented in resistance management programs. Recent work suggests that genomic approaches can identify signs of emerging resistance to aid in resistance management. Here, we empirically examined the sensitivity of genomic monitoring for resistance management in transgenic Bt crops, a globall...
• A minimal physical model for curvotaxis driven by curved protein complexes at the cell's leading edge AI翻译
  作者：Sadhu, Raj Kumar; Lucianob, Marine; Xi, Wang; Martinez-Torres, Cristina; Schroeder, Marcel; Blum, Christoph; Tarantola, Marco; Villa, Stefano; Penic, Samo; Iglic, Ales; Betae, Carsten; Steinbock, Oliver; Bodenschatz, Eberhard; Ladoux, Benoit; Gabriele, Sylvain; Gov, Nir S.
  作者单位：Weizmann Institute of Science; University of Geneva; University of Mons; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; University of Potsdam; Max Planck Society; University of Ljubljana; Kanazawa University; State University System of Florida; Florida State University; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite PSL; UNICANCER; Institut Curie; Sorbonne Universite
  摘要：Cells often migrate on curved surfaces inside the body, such as curved tissues, blood vessels, or highly curved protrusions of other cells. Recent in vitro experiments provide clear evidence that motile cells are affected by the curvature of the substrate on which they migrate, preferring certain curvatures to others, termed curvotaxis. The origin and underlying mechanism that gives rise to this curvature sensitivity are not well understood. Here, we employ a minimal cell model which is compos...
• Instructed motivational states bias reinforcement learning and memory formation (vol 120, e2304881120, 2023) AI翻译
  作者：Sinclair, Alyssa H.; Wang, Yuxi C.; Adcock, R. Alison
• Temperature anomalies undermine the health of reproductive-age women in low- and middle- income countries AI翻译
  作者：Gray, Clark; Thiede, Brian C.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill
  摘要：Climate change is expected to undermine population health and well-being in low- and middle-income countries, but relatively few analyses have directly examined these effects using individual-level data at global scales, particularly for reproductive-age women. To address this lacuna, we harmonize nationally representative data from the Demographic and Health Surveys on reproductive health, body mass index (BMI), and temporary migration from 2.5 million adult women (ages 15 to 49) in approxima...
• Ingested soil bacteria breach gut epithelia and prime systemic in an insect AI翻译
  作者：Jang, Seonghan; Ishigami, Kota; Mergaert, Peter; Kikuchi, Yoshitomo
  作者单位：National Institute of Advanced Industrial Science & Technology (AIST); Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Hokkaido University; Korea Research Institute of Bioscience & Biotechnology (KRIBB)
  摘要：Insects lack acquired immunity and were thought to have no immune memory, but recent studies reported a phenomenon called immune priming, wherein sublethal dose of pathogens or nonpathogenic microbes stimulates immunity and prevents subsequential pathogen infection. Although the evidence for insect immune priming is accumulating, the underlying mechanisms are still unclear. The bean bug Riptortus pedestris acquires its gut microbiota from ambient soil and spatially structures them into a multi...
• Ambient sound stimulation tunes axonal conduction velocity by regulating radial growth of myelin on an individual, axon- by- axon basis AI翻译
  作者：Stancu, Mihai; Wohlfrom, Hilde; Hess, Martin; Grothe, Benedikt; Leibold, Christian; Kopp-Scheinpflug, Conny
  作者单位：University of Munich; University of Munich; University of Freiburg
  摘要：Adaptive myelination is the emerging concept of tuning axonal conduction velocity to the activity within specific neural circuits over time. Sound processing circuits exhibit structural and functional specifications to process signals with microsecond precision: a time scale that is amenable to adjustment in length and thickness of myelin. Increasing activity of auditory axons by introducing sound- evoked responses during postnatal development enhances myelin thickness, while sensory deprivati...
• Strategy to develop broadly effective multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform AI翻译
  作者：Chang, Soojeong; Shin, Kwang-Soo; Park, Bongju; Park, Seowoo; Shin, Jieun; Park, Hyemin; Jung, In Kyung; Kim, Jong Heon; Bae, Seong Eun; Kim, Jae- Ouk; Baek, Seung Ho; Kim, Green; Hong, Jung Joo; Seo, Hyungseok; Volz, Erik; Kang, Chang- Yuil
  作者单位：International Vaccine Institute; Korea Research Institute of Bioscience & Biotechnology (KRIBB); Korea Research Institute of Bioscience & Biotechnology (KRIBB); Seoul National University (SNU); Imperial College London
  摘要：The severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) Omicron strain has evolved into highly divergent variants with several sub- lineages. These newly emerging variants threaten the efficacy of available COVID-19 vaccines. To mitigate the occurrence of breakthrough infections and re- infections, and more importantly, to reduce the disease burden, it is essential to develop a strategy for producing updated multivalent vaccines that can provide broad neutralization against both curr...
• Proofreading does not result in more reliable ligand discrimination in receptor signaling due to its inherent stochasticity (vol 120, e22127955120, 2023) AI翻译
  作者：[Anonymous]
• Sec7 regulatory domains scaffold autoinhibited and active conformations AI翻译
  作者：Brownfield, Bryce A.; Richardson, Brian C.; Halaby, Steve L.; Fromme, J. Christopher
  作者单位：Cornell University; Cornell University; University of Minnesota System; AbbVie
  摘要：The late stages of Golgi maturation involve a series of sequential trafficking events in which cargo - laden vesicles are produced and targeted to multiple distinct subcellular destinations. Each of these vesicle biogenesis events requires activation of an Arf GTPase by the Sec7/BIG guanine nucleotide exchange factor (GEF). Sec7 localization and activity is regulated by autoinhibition, positive feedback, and interaction with other GTPases. Although these mechanisms have been characterized bioc...
• Interplay between autophagy and CncC regulates dendrite pruning in Drosophila AI翻译
  作者：Tan, Jue Yu Kelly; Chew, Liang Yuh; Juhasz, Gabor; Yu, Fengwei
  作者单位：National University of Singapore; National University of Singapore; Eotvos Lorand University; HUN-REN; HUN-REN Biological Research Center; Institute of Genetics - HAS
  摘要：Autophagy is essential for the turnover of damaged organelles and long - lived proteins. It is responsible for many biological processes such as maintaining brain functions and aging. Impaired autophagy is often linked to neurodevelopmental and neurodegenerative diseases in humans. However, the role of autophagy in neuronal pruning during development remains poorly understood. Here, we report that autophagy regulates dendrite- specific pruning of ddaC sensory neurons in parallel to local caspa...