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作者：Xia, Yisui; Sonneville, Remi; Jenkyn-Bedford, Michael; Ji, Liqin; Alabert, Constance; Hong, Ye; Yeeles, Joseph T. P.; Labib, Karim P. M.
作者单位：University of Dundee; MRC Laboratory Molecular Biology; Shandong University; University of Dundee; Shenzhen University; Rockefeller University
摘要：Assembly of the CMG (CDC-45-MCM-2-7-GINS) helicase is the key regulated step during eukaryotic DNA replication initiation. Until now, it was unclear whether metazoa require additional factors that are not present in yeast. In this work, we show that Caenorhabditis elegans DNSN-1, the ortholog of human DONSON, functions during helicase assembly in a complex with MUS-101/TOPBP1. DNSN-1 is required to recruit the GINS complex to chromatin, and a cryo-electron microscopy structure indicates that D...
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作者：Porrett, Paige M.
作者单位：University of Alabama System; University of Alabama Birmingham
摘要：When pregnant, maternal immunologic tolerance is required to ensure that the fetus is not rejected by the mother's immune system. This tolerance is achieved by expansion of a subset of CD4(+) T cells with regulatory properties (T-reg cells) that protect against fetal loss (1-3). Maternal T-reg cells develop immunologic memory, which confers fetal-specific protection against complications in subsequent pregnancy (4). Prior studies have suggested that memory T-reg cells are sustained by fetal mi...
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作者：Pouikli, Andromachi; Frezza, Christian
作者单位：University of Cologne; University of Cologne
摘要：The metabolism of cancer cells adapts to meet an increased need for the energy, biosynthesis, and antioxidants required for proliferation, tumor growth, and metastasis (1). Yet, whether this metabolic reprogramming affects the recognition and elimination of cancer cells by immune cells has not been well investigated. On page 1316 of this issue, Mangalhara et al. (2) report a connection between a cancer cell's mitochondrial metabolism and its ability to evoke an immune response in a mouse model...
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作者：Jacobs, Phie
摘要：Half-million-year-old structure unearthed in Zambia may have been a platform, bridge, or house foundation
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作者：Rubinoff, Daniel; Gon, Samuel M. 'Ohukani'ohi'a, III
作者单位：University of Hawaii System; Nature Conservancy
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作者：Bjorkland, Rhema
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作者：Brainard, Jeffrey
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作者：Chaplin, Lan Nguyen
作者单位：Northwestern University
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作者：Squair, Jordan W.; Milano, Marco; de Coucy, Alexandra; Gautier, Matthieu; Skinnider, Michael A.; James, Nicholas D.; Cho, Newton; Lasne, Anna; Kathe, Claudia; Hutson, Thomas H.; Ceto, Steven; Baud, Laetitia; Galan, Katia; Aureli, Viviana; Laskaratos, Achilleas; Barraud, Quentin; Deming, Timothy J.; Kohman, Richie E.; Schneider, Bernard L.; He, Zhigang; Bloch, Jocelyne; Sofroniew, Michael V.; Courtine, Gregoire; Anderson, Mark A.
作者单位：Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of Lausanne; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulations to their natural target regions remains unclear. To address this question, we applied projection-specific and comparative single-nucleus RNA sequencing to identify neuronal subpopulations that restore walking after incomplete SCI. We show ...
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作者：Marsh, Joseph A.; Teichmann, Sarah A.
作者单位：University of Edinburgh; Wellcome Trust Sanger Institute; University of Cambridge
摘要：Many of the genetic mutations that cause disease in humans occur in protein-coding regions. Although the capacity to sequence DNA and identify these variants has substantially increased, the ability to interpret their effects remains limited. This problem is particularly acute for missense variants, which involve substitution of a single amino acid residue and make up the overwhelming majority of variants of uncertain significance (VUS), as classified by clinicians (1). On page 1303 of this is...
