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作者：Simonti, Corinne; Seale, Madeleine
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作者：Huderson, Ashley
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作者：Kuhlman, Thomas E.
作者单位：University of California System; University of California Riverside
摘要：Approximately 5% of the human genome consists of short tandem repeats (STRs), sequences in which repeating units of 1 to 6 base pairs form an array of up to 100 base pairs long (1, 2). Variations in STR length are associated with, and often the causative agents of, gene expression changes present in some hereditary conditions, for example, Huntington's disease, autism, and schizophrenia (3-5). However, the mechanisms through which STRs exert their effects on gene expression remain poorly under...
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作者：Buckley, Ralf
作者单位：Griffith University; Griffith University - Gold Coast Campus
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作者：Song, Jiarui; Gooding, Anne R.; Hemphill, Wayne O.; Love, Brittney D.; Robertson, Anne; Yao, Liqi; Zon, Leonard I.; North, Trista E.; Kasinath, Vignesh; Cech, Thomas R.
作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; Howard Hughes Medical Institute; Harvard University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Harvard Medical School
摘要：Polycomb repressive complex 2 (PRC2) silences genes through trimethylation of histone H3K27. PRC2 associates with numerous precursor messenger RNAs (pre-mRNAs) and long noncoding RNAs (lncRNAs) with a binding preference for G-quadruplex RNA. In this work, we present a 3.3-angstrom-resolution cryo-electron microscopy structure of PRC2 bound to a G-quadruplex RNA. Notably, RNA mediates the dimerization of PRC2 by binding both protomers and inducing a protein interface composed of two copies of t...
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作者：[Anonymous]
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作者：Boller, Kimberly
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作者：Brainard, Jeffrey
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作者：Prieto-Curiel, Rafael; Campedelli, Gian Maria; Hope, Alejandro
作者单位：University of Trento
摘要：Mexican cartels lose many members as a result of conflict with other cartels and incarcerations. Yet, despite their losses, cartels manage to increase violence for years. We address this puzzle by leveraging data on homicides, missing persons, and incarcerations in Mexico for the past decade along with information on cartel interactions. We model recruitment, state incapacitation, conflict, and saturation as sources of cartel size variation. Results show that by 2022, cartels counted 160,000 t...
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作者：Shao, Tzu-Yu; Kinder, Jeremy M.; Harper, Gavin; Pham, Giang; Peng, Yanyan; Liu, James; Gregory, Emily J.; Sherman, Bryan E.; Wu, Yuehong; Iten, Alexandra E.; Hu, Yueh-Chiang; Russi, Abigail E.; Erickson, John J.; Miller-Handley, Hilary; Way, Sing Sing
作者单位：University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati
摘要：Pregnancy confers partner-specific protection against complications in future pregnancy that parallel persistence of fetal microchimeric cells (FMcs) in mothers after parturition. We show that preexisting FMcs become displaced by new FMcs during pregnancy and that FMc tonic stimulation is essential for expansion of protective fetal-specific forkhead box P3 (FOXP3)-positive regulatory T cells (T-reg cells). Maternal microchimeric cells and accumulation of T-reg cells with noninherited maternal ...
