2025

最新文章

• Generative AI for computational chemistry: A roadmap to predicting emergent phenomena AI翻译
  作者：Tiwary, Pratyush; Herron, Lukas; John, Richard; Lee, Suemin; Sanwal, Disha; Wang, Ruiyu
  作者单位：University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park
  摘要：The recent surge in generative AI has introduced exciting possibilities for computational chemistry. Generative AI methods have made significant progress in sampling molecular structures across chemical species, developing force fields, and speeding up simulations. This Perspective offers a structured overview, beginning with the fundamental theoretical concepts in both generative AI and computational chemistry. It then covers widely used generative AI methods, including autoencoders, generati...
• Recent drying of the Ganga River is unprecedented in the last 1,300 years AI翻译
  作者：Chuphal, Dipesh Singh; Thirumalai, Kaustubh; Mishra, Vimal
  作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Gandhinagar; University of Arizona; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Gandhinagar
  摘要：The Ganga River basin, critical to over 600 million people, is experiencing a severe and unprecedented drying trend, threatening water and food security. Using streamflow reconstructions spanning 1,300 y (700-2012 C.E.) from instrumental data, paleohydrological records, and hydrological modeling, we show that drying from 1991 to 2020 is unmatched in the past millennium. Streamflow decline since the 1990s, driven by frequent and prolonged droughts, is 76% more intense than the 16th- century dro...
• Rust never sleeps: Climate change, permafrost thaw, and the rapid environmental degradation of wilderness river ecosystems AI翻译
  作者：Huryn, Alexander D.
  作者单位：University of Alabama System; University of Alabama Tuscaloosa
• The multimodal transcriptional response of denervated skeletal muscle involves regulation of Gramd1 genes impacting muscle size AI翻译
  作者：Calvo, Cristofer; Swoboda, Casey O.; Morales, Fabian Montecino-; Nagar, Siddhant; Petrany, Michael J.; Sun, Chengyi; Durumutla, Hima Bindu; Quattrocelli, Mattia; Millay, Douglas P.
  作者单位：Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati
  摘要：The development and maintenance of the neuromuscular junction (NMJ) requires reciprocal signals between the nerve terminals and multinucleated skeletal muscle fibers (myofibers). This interaction drives highly specialized transcription in the subsynaptic or NMJ myonuclei within mature myofibers leading to clustering of acetylcholine receptors (AChRs). Here, we utilized single-nucleus RNA sequencing (snRNA-seq) to delineate the transcriptional response of myonuclei to denervation. Through snRNA...
• Exploring the sub-Neptune frontier with JWST AI翻译
  作者：Madhusudhan, Nikku; Holmberg, Mans; Constantinou, Savvas; Cooke, Gregory J.
  作者单位：University of Cambridge; Space Telescope Science Institute
  摘要：Sub-Neptune planets, with sizes and masses between those of Earth and Neptune, dominate the exoplanet population. Sub-Neptunes are expected to be the most diverse family of the exoplanet population, potentially including rocky gas dwarfs, water worlds, and mini-Neptunes, with a wide range of atmospheric, surface, and interior conditions. With no analogue in the solar system, these planets open fundamental questions in planetary processes, origins, and habitability, and present avenues in the s...
• Strategic planning of prevention and surveillance for emerging diseases and invasive species AI翻译
  作者：Wang, Jue; Hanley, Brenda J.; Thompson, Noelle E.; Gong, Yu; Walsh, Daniel P.; Gonzalez-Crespo, Carlos; Huang, Yitong; Booth, James G.; Caudell, Joe N.; Miller, Landon A.; Schuler, Krysten L.
  作者单位：Queens University - Canada; Cornell University; Cornell University; University of Montana System; United States Department of the Interior; University of Montana; United States Geological Survey; University of California System; University of California Davis; Cornell University
  摘要：Emerging infectious diseases and biological invasions pose increasing threats to public and ecosystems health. Proactive measures-such as prevention and surveillance taken before initial detection of the pathogen or species-are essential to ensure minimal spread prior to first detection. We developed an optimization model to determine where, when, and how much effort should be allocated to prevention versus surveillance. The model accounts for imperfect detection, system dynamics, spatial hete...
• Distinct timescales dissociate spontaneous thought dimensions AI翻译
  作者：Hua, Jingyu; Ge, Xianliang; Dou, Min; Zhang, Yuqi; Ge, Liezhong; Fogel, Stuart; Zhang, Jianfeng; Northoff, Georg
  作者单位：Shenzhen University; Zhejiang University; University of Ottawa; University of Ottawa; Shaanxi Normal University
  摘要：Our spontaneous thoughts encompass various dimensions, such as task-relatedness (off vs. on task), and thought orientation (internal vs. external). However, their distinction remains unclear. Our study addresses this issue by focusing on their timescales at both the behavioral level (using fast and slow finger tapping) and the neural level (using EEG) using two independent datasets (N = 84 and 35). Behavioral results revealed a double dissociation: Task-relatedness was linked to fast tapping o...
• Hybridoma-inspired strategy crafts tailored multifunctional exosomes for precision therapy AI翻译
  作者：Dong, Zhufeng; Yin, Tieyin; Deng, Zhiqin; Zou, Hang; Kuang, Lei; Wang, Yang; Shi, Wen; Han, Mengwei; Zhu, Siqing; Wang, Zheng; Hu, Xiaoye; Wang, Yazhou Z.
  作者单位：Chongqing University; Chongqing University
  摘要：Engineering functional exosomes represents a cutting-edge approach in biomedicine, holding the promise to transform targeted therapy. However, challenges such as achieving consistent modification and scalability have limited their wider adoption. Herein, we introduce a universal and effective strategy for engineering multifunctional exosomes through cell fusion. The hybrid-cell-derived exosomes could combine the functional properties of both parental cells and be readily produced by passaging....
• Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell-based microfluidic platforms AI翻译
  作者：Gomes, Catia; Huang, Kang-Chieh; Lavekar, Sailee S.; Harkin, Jade; Prosser, Carson G.; Fang, Yue; Kalem, Claire; Oblak, Adrian; Zhang, Chi; Meyer, Jason S.
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Indianapolis; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington
  摘要：Retinal ganglion cells (RGCs) are highly compartmentalized neurons whose long axons serve as the sole connection between the eye and the brain. In both injury and disease, RGC degeneration occurs in a similarly compartmentalized manner, with distinct molecular and cellular responses in the axonal and somatodendritic regions. The goal of this study was to establish a microfluidic-based platform to investigate RGC compartmentalization in both health and disease states. Human pluripotent stem cel...
• PI31 expression is neuroprotective in a mouse model of early- onset parkinsonism AI翻译
  作者：Rodriguez, Jose A.; Minis, Adi; Aref, Rasha; Nguyen, Hieu Hoang Minh; Sun, Fiona; Steller, Hermann; Chao, Moses
  作者单位：Rockefeller University; Stanford Medicine; Stanford University
  摘要：Neurodegenerative diseases present one of the most significant global health challenges. These disorders are defined by the accumulation of abnormal protein aggregates that impair synaptic function and cause progressive neuronal degeneration. Therefore, stimulating protein clearance mechanisms may be neuroprotective. Variants in FBXO7/ PARK15 cause Parkinsonian Pyramidal Syndrome, an early-onset parkinsonian neurodegenerative disorder in humans, and inactivation of this gene in mice recapitula...