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作者：Liu, Xin; Balligand, Thomas; Le Gall, Camille; Ploegh, Hidde L.
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard Medical School
摘要：Influenza remains a significant public health threat. Both monoclonal antibodies and small-molecule inhibitors can target the influenza surface glycoproteins hemagglutinin (HA) or neuraminidase (NA) for prevention and treatment of influenza. Here, we combine the strengths of anti-influenza antibodies and small molecules by site-specific conjugation of the NA inhibitor zanamivir to MEDI8852, an HA-specific fully human monoclonal antibody. MEDI8852 targets the conserved stem region of HA and inh...
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作者：Arakawa, Masashi; Uriu, Keiya; Saito, Koki; Hirose, Mai; Katoh, Kaoru; Asano, Krisana; Nakane, Akio; Saitoh, Tatsuya; Yoshimori, Tamotsu; Morita, Eiji
作者单位：Hirosaki University; National Institute of Advanced Industrial Science & Technology (AIST); Hirosaki University; University of Osaka; University of Osaka; University of Osaka; University of Osaka
摘要：Bacterial invasion into the cytoplasm of epithelial cells triggers the activation of the cellular autophagic machinery as a defense mechanism, a process known as xenophagy. In as a factor involved in this defense mechanism using quantitative mass spectrometry promotes Salmonella proliferation in the cytoplasm. HEATR3 also localizes to lysosomes damaged by chemical treatment, suggesting that Salmonella recognition is facilitated by damage to the host cell membrane. HEATR3 deficiency impairs LC3...
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作者：Kenngott, Max; Sengupta, Piali; Lockery, Shawn; Marder, Eve
作者单位：Brandeis University; Brandeis University; Brandeis University; University of Oregon
摘要：The nematode Caenorhabditis elegans feeds by rhythmic contraction and relaxation of a neuromuscular organ called the pharynx, which draws in and filters water and bacterial food. This behavior is driven by myogenic plateau potentials, long-lasting depolarizations of the pharyngeal muscle, which are timed by neuronal input from a dedicated pharyngeal nervous system. While the timing of these plateaus' initiation has received significant attention, their mechanisms of termination remain incomple...
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作者：Yao, Lu; Feng, Wei; Cornelio, Chiara; Shimamoto, Toshihiko; Ma, Shengli; Di Toro, Giulio
作者单位：China Earthquake Administration; Institute of Geology, CEA; University of Padua; Istituto Nazionale Geofisica e Vulcanologia (INGV)
摘要：Seismic fault slip and rupture propagation often occur at crustal depths in the presence of hot and pressurized aqueous fluids (i.e., hydrothermal conditions). Previous experiments investigated fault frictional properties under hydrothermal conditions, but at imposed subseismic fault slip velocities (V similar to mu m/s). Here, using a rotary-shear apparatus equipped with a hydrothermal pressure vessel, we study friction at seismic slip velocities (V = 1.5 m/s) of gabbro-and marble-built fault...
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作者：Gabriel, Rodney A.
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego
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作者：Bolsterlee, Bart; Chow, Brian V. Y.; Yu, Jonathan; Davies, Suzanne; Morgan, Catherine; Rae, Caroline D.; Warton, David I.; Novak, Iona; Lancaster, Ann; Popovic, Gordana C.; Rizzo, Rodrigo R. N.; Rizzo, Claudia Y.; Ball, Iain K.; Herbert, Robert D.
作者单位：Neuroscience Research Australia; University of New South Wales Sydney; University of New South Wales Sydney; University of Sydney; Cerebral Palsy Alliance - Australia; University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; University of Sydney; University of New South Wales Sydney; University of New South Wales Sydney
摘要：Skeletal muscles grow substantially during childhood. However, quantitative information about the size of typically developing children's muscles is sparse. Here, the objective was to construct muscle- specific reference curves for lower leg muscle volumes in children aged 5 to 15 y. Volumes of 10 lower leg muscles were measured from magnetic resonance images of 208 typically developing children and 78 ambulant children with cerebral palsy. Deep learning was used to automatically segment the i...
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作者：Huang, Yuheng; Gao, Zita Y.; Ly, Kayla; Lin, Leila; Lambooij, Jan Paul; King, Elizabeth G.; Janssen, Aniek; Wei, Kevin H. -C.; Lee, Yuh Chwen G.
作者单位：University of California System; University of California Irvine; Utrecht University; Utrecht University Medical Center; University of Missouri System; University of Missouri Columbia; University of British Columbia
摘要：Meiotic recombination is a prominent force shaping genome evolution, and understanding why recombination rates vary within and between species has remained a central, though challenging, question. Variation in recombination is widely thought to influence the efficacy of selection in purging transposable elements (TEs), prevalent selfish genetic elements, leading to widely observed negative correlations between TE abundance and recombination rates across taxa. However, accumulating evidence sug...
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作者：Mattingly, Henry H.
作者单位：Simons Foundation; Flatiron Institute
摘要：Bacterial motility in spatially structured environments impacts a variety of natural and engineering processes. Constructing models to predict, control, and design bacterial motility for these processes remains challenging because bacteria and active swimmers have complex interactions with surfaces and because the precise environment geometry is unknown. Here, we present a method for deriving bacterial diffusion coefficients in disordered media in terms of cell and environmental parameters. Th...
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作者：Narasimhan, Badri Narayanan; Fraley, Stephanie I.
作者单位：University of California System; University of California San Diego
摘要：In native extracellular matrices (ECM), cells utilize matrix metalloproteinases (MMPs) to degrade and remodel their microenvironment. Accordingly, synthetic matrices have been engineered to permit MMP-mediated cleavage, facilitating cell spreading, migration, and interactions. However, the interplay between matrix degradability and mechanical properties remains underexplored. We hypothesized that MMP activity induces immediate mechanical alterations in the ECM, which are subsequently detected ...
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作者：Zhu, Tian-Chen; He, Zhang-Ping; Li, Shu-Ting; Zheng, Lin; Zheng, Xue-Yi; Lan, Xia-Lu; Qu, Chun-Hua; Nie, Run-Cong; Gu, Chao; Huang, Li-Ning; Cai, Xiao-Xia; Xiang, Zhi-Cheng; Xie, Dan; Cai, Mu-Yan
作者单位：State Key Lab Oncology South China; Sun Yat Sen University; State Key Lab Oncology South China; Sun Yat Sen University; Guangzhou Medical University; Fujian Medical University; Fujian Medical University; Sun Yat Sen University; State Key Lab Oncology South China; Nanjing Medical University
摘要：Poly-ADP-ribose polymerase (PARP) inhibitors are vital therapeutic agents that exploit synthetic lethality, particularly effective in tumors with homologous recombination (HR) defects. However, broadening their clinical utility remains a significant challenge. In this study, we conducted a high-throughput kinase inhibitor screen to identify potential targets exhibiting synthetical lethality with PARP inhibitors. Our results show that thousand and one amino acid protein kinase 1 (TAOK1) plays a...
