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作者：Lynch, Vincent J.
作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY
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作者：Riel, Elena B.; Bu, Weiming; Joseph, Thomas T.; Khajoueinejad, Leila; Eckenhoff, Roderic G.; Riegelhaupt, Paul M.
作者单位：Cornell University; Weill Cornell Medicine; University of Pennsylvania
摘要：THIK1 tandem pore domain (K2P) potassium channels regulate microglial surveillance of the central nervous system and responsiveness to inflammatory insults. With microglia recognized as critical to the pathogenesis of neurodegenerative diseases, THIK1 channels are putative therapeutic targets to control microglia dysfunction. While THIK channels can principally be distinguished from other K2Ps by their distinctive inhibitory response to volatile anesthetics (VAs), molecular details governing T...
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作者：Zhu, Xingrui; Zhang, Yuanxing; Hanson, Benjamin L.; Wu, David T.; Wu, Ning
作者单位：Colorado School of Mines; Colorado School of Mines; Academia Sinica - Taiwan
摘要：Chiral structures assembled from colloids are of great interest for applications in meta-materials and micromachines. However, similar to their molecular counterparts, these assemblies often result in racemic mixtures. Achieving homochirality by breaking the symmetry remains a significant challenge. Here, we report an approach to obtain single-handed clusters from colloidal dimers using orthogonal electric and magnetic fields. Applying an alternating-current electric field perpendicular to the...
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作者：Hirano, Tomohiro; Toda, Alexis Akira
作者单位：University of London; Royal Holloway University London; Emory University
摘要：Historical trends suggest the decline in the importance of land as a production factor, as evidenced by the decline in the employment and gross domestic product (GDP) shares of land-intensive industries. However, land continues to be a prominent store of value, as over half of household wealth in major countries is real estate. To explain this apparent disconnection between land output and land value, in a plausible economic model with land and aggregate risk, we theoretically study the long-r...
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作者：Hardcastle, Matthew
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作者：Li, Zixuan; Moir, Camilla M.; McKee, Nathan J.; Lee-Wong, Eric; Baumbach, Ryan E.; Maple, M. Brian; Liu, Ying
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California San Diego; University of California System; University of California San Diego; State University System of Florida; Florida State University; State University System of Florida; Florida State University
摘要：Symmetry properties of the order parameter are among the most fundamental characteristics of a superconductor. UTe2, which was found to feature an exceedingly large upper critical field and striking reentrant behavior at low temperatures, is widely believed to possess a spin-triplet pairing symmetry. However, unambiguous evidence for such a pairing symmetry is still lacking, especially at zero and low magnetic fields. The presence of an inversion crystalline symmetry in UTe2 requires that, if ...
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作者：Ogawa, Takumi; Koyama, Shuji; Omori, Toshihiro; Kikuchi, Kenji; de Maleprade, Helene; Goldstein, Raymond E.; Ishikawa, Takuji
作者单位：Tohoku University; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; University of Cambridge; Tohoku University
摘要：Sponges, the basalmost members of the animal kingdom, exhibit a range of complex architectures in which microfluidic channels connect multitudes of spherical chambers lined with choanocytes, flagellated filter-feeding cells. Choanocyte chambers can possess scores or even hundreds of such cells, which drive complex flows entering through porous walls and exiting into the sponge channels. One of the mysteries of the choanocyte chamber is its spherical shape, as it seems inappropriate for inducin...
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作者：Zhang, Xin; Wu, Jingyi; Min, Zhenzhen; Wang, Jiamao; Hong, Xin; Pei, Xinkai; Rao, Zihe; Xu, Xiaoling
作者单位：Hangzhou Normal University; Hangzhou Normal University; Tsinghua University
摘要：F-type ATP synthase (F1FO) catalyzes proton motive force-driven ATP synthesis in mitochondria, chloroplasts, and bacteria. Different from the mitochondrial and bacterial enzymes, F1FO from photosynthetic organisms have evolved diverse structural and mechanistic details to adapt to the light-dependent reactions. Although complete structure of chloroplast F1FO has been reported, no high-resolution structure of an F1FO from photosynthetic bacteria has been available. Here, we report cryo-EM struc...
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作者：Hyder, Safwan K.; Lazarini-Lopes, Willian; Toib, Jonathan; Williams, Gabrielle; Sukharev, Alexander; Forcelli, Patrick A.
作者单位：Georgetown University; Georgetown University
摘要：Despite a century of development of antiseizure medications, up to a third of people with epilepsy do not achieve seizure freedom with drug therapy. Deep brain stimulation is of growing use, but just as with pharmacotherapy, is not universally effective. Identifying new targets for deep brain stimulation-and in particular sites that are effective against a range of seizure types-may close this gap. Engagement of the basal ganglia experimental seizures was first observed almost 75 y ago. Howeve...
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作者：Chen, Gang; Lv, Guangxin; Zhang, James H.; Tu, Yaodong
作者单位：Massachusetts Institute of Technology (MIT); Nanjing University; Chinese Academy of Sciences; Dalian Institute of Chemical Physics, CAS
