2025

最新文章

• Food Rx: Integrating horticulture research to improve nutrition and health AI翻译
  作者：Gunter, Christopher C.; Treadwell, Danielle D.; Resende Jr, Marcio F. R.; Whitaker, Vance M.; Balmant, Kelly M.; Shelnutt, Karla P.; Borum, Peggy R.; Andrade, Juan E.; Goodrich-Schneider, Renee; Bernier, Angelina, V; Donahoo, William T.; Jaffee, Michael S.; Angle, J. Scott; Hanson, Andrew D.
  作者单位：State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida
  摘要：It is clear that the escalating epidemic of insulin resistance and type 2 diabetes has reached a crisis level in the United States, that overweight and obesity are drivers, and that diets and the food system have major roles. It is also clear that nutrition and medical research point to increased healthful fruit and vegetable intake as a key part of any strategy to manage the crisis. But although increasing healthful intake entails both expanding production of fruits and vegetables and improvi...
• Visualization and quantification of local concentration gradients in evaporating water/glycerol droplets with micrometer resolution AI翻译
  作者：Erb, Alexander; Kind, Jonas; Zankel, Timon L.; Stark, Robert W.; Thiele, Christina M.
  作者单位：Technical University of Darmstadt; Technical University of Darmstadt
  摘要：Evaporation of sessile multicomponent droplets is ubiquitous in many common processes, such as printing, cooling, and coating. The evaporation rate is not evenly distributed across the surface of the droplet. As a result, there are regions with high evaporation rates in which the more volatile part evaporates preferentially; this can induce local surface tension gradients, which, in combination with density differences, can lead to flows within the droplet originating from local concentration ...
• Incorporation of polylactic acid microplastics into the carbon cycle as a carbon source to remodel the endogenous metabolism of the gut AI翻译
  作者：Bao, Lin; Cui, Xuejing; Zeng, Tao; Liu, Guanyu; Lai, Wenjia; Zhao, Hao; Gao, Fene; Wu, Junguang; Leong, Kam W.; Chen, Chunying
  作者单位：Chinese Academy of Sciences; Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, CAS; Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Medical Sciences - Peking Union Medical College; Sun Yat Sen University; Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Columbia University
  摘要：Biodegradable polylactic acid (PLA) plastics have been praised as an effective solution to the global pollution caused by petroleum-based plastics, and their widespread use in food packaging and disposable tableware has resulted in increased oral exposure to PLA microplastics (PLA-MPs). Despite their eco-friendly and biodegradable reputation, the in vivo behaviors of PLA-MPs concerning fermentation, carbon cycle, and adverse effects remain unknown. Here, we showed that gut microbiota from the ...
• The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes AI翻译
  作者：Jauregi-Miguel, Amaia; Soderholm, Simon; Weiss, Tamina; Nordin, Anna; Ghezzi, Valeria; Brutsch, Salome M.; Pagella, Pierfrancesco; van de Grift, Yorick; Zambanini, Gianluca; Ulisse, Jacopo; Mattia, Alessandro; Deviatiiarov, Ruslan; Faustini, Elena; Moparthi, Lavanya; Zhong, Wenjing; Bjornsson, Bergthor; Sandstrom, Per; Lundqvist, Erik; Lottersberger, Francisca; Koch, Stefan; Moor, Andreas E.; Sun, Xiao-Feng; von Castelmur, Eleonore; Sheng, Guojun; Cantu, Claudio
  作者单位：Linkoping University; Linkoping University; Linkoping University; Linkoping University; Kazan Federal University; Russian Academy of Medical Sciences; Endocrinology Research Centre; Juntendo University; Linkoping University; Linkoping University; Linkoping University; Linkoping University; Linkoping University; Linkoping University; Kumamoto University; Max Planck Society
  摘要：Wnt signaling orchestrates gene expression in a plethora of processes during development and adult cell homeostasis via the action of nuclear beta-catenin. Yet, little is known about how beta-catenin generates context-specific transcriptional outcomes. Understanding this will reveal how aberrant Wnt/beta-catenin signaling causes neoplasia specifically of the colorectal epithelium. We have previously identified the transcription factor TBX3 as a tissue-specific component of the Wnt/beta-catenin...
• Scattering diagrams, tight gradings, and generalized positivity AI翻译
  作者：Burcroff, Amanda; Lee, Kyungyong; Mou, Lang
  作者单位：Harvard University; University of Alabama System; University of Alabama Tuscaloosa; Korea Institute for Advanced Study (KIAS); University of Cologne
  摘要：In 2013, Lee, Li, and Zelevinsky introduced combinatorial objects called compatible pairs to construct the greedy bases for rank-2 cluster algebras, consisting of indecomposable positive elements including the cluster monomials. Subsequently, Rupel extended this construction to the setting of generalized rank-2 cluster algebras by defining compatible gradings. We find a class of combinatorial objects which we call tight gradings. Using this, we give a directly computable, manifestly positive, ...
• Induced B cell receptor diversity predicts PD-1 blockade immunotherapy response AI翻译
  作者：Che, Yonglu; Lee, Jinwoo; Abou-Taleb, Farah; Rieger, Kerri E.; Satpathy, Ansuman T.; Chang, Anne Lynn S.; Chang, Howard Y.
  作者单位：Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University
  摘要：Immune checkpoint inhibitors such as anti-Programmed Death-1 antibodies (aPD-1) can be effective in treating advanced cancers. However, many patients do not respond, and the mechanisms underlying these differences remain incompletely understood. In this study, we profile a cohort of patients with locally advanced or metastatic basal cell carcinoma undergoing aPD-1 therapy using single-cell RNA sequencing, high-definition spatial transcriptomics in tumors and draining lymph nodes, and spatial i...
• Copy- cat evolution: Divergence and convergence within and between cat and dog breeds AI翻译
  作者：Drake, Abby Grace; Revell, Liam J.; Klingenberg, Christian Peter; Lattimer, Jimmy C.; Nelson, Nathan C.; Schmidt, Martin J.; Zwingenberger, Allison L.; Moyer, Joshua K.; Losos, Jonathan B.
  作者单位：Cornell University; University of Massachusetts System; University of Massachusetts Boston; University of Manchester; University of Missouri System; University of Missouri Columbia; North Carolina State University; Justus Liebig University Giessen; University of California System; University of California Davis; Yale University; Washington University (WUSTL)
  摘要：Many domesticated species exhibit remarkable phenotypic diversity. In nature, selection produces not only divergence but also convergence when organisms experience similar selective pressures. Whether artificial selection during domestication also produces convergence has received little attention. Three-dimensional shape analysis of domestic cat and dog skulls demonstrated convergence at multiple levels. Most broadly, cats and dogs have both diversified greatly: equaling or exceeding the morp...
• A twist grain boundary phase in aqueous solutions of the nucleic acid tetramer GTAC AI翻译
  作者：Smith, Gregory P.; Zhu, Chenhui; Zernenkov, Mikail; Frechet, Guillaume; Clark, Noel A.
  作者单位：University of Colorado System; University of Colorado Boulder; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Brookhaven National Laboratory
  摘要：At high concentration, long Watson/Crick (WC) double-helixed DNA forms columnar crystal or liquid crystal phases of linear, parallel duplex chains packed on periodic lattices. This can also be a structural motif of short NA oligomers such as the 5'- GTAC-3' studied here, which makes four-base WC duplexes having hydrophobic blunt ends. End-to-end aggregation then assembles these duplexes into columns and columnar phases are stabilized, in spite of breaks in the double helix every four bases. Bu...
• Antiviral resistance and barrier integrity at the maternal- fetal interface restrict hepatitis E virus from crossing the placental barrier AI翻译
  作者：Tian, Debin; Li, Wen; Heffron, C. Lynn; Mahsoub, Hassan M.; Wang, Bo; LeRoith, Tanya; Meng, Xiang-Jin
  作者单位：Virginia Polytechnic Institute & State University; Virginia Polytechnic Institute & State University
  摘要：Hepatitis E virus (HEV) genotype 1 (HEV-1) infection in pregnant women is associated with adverse outcomes of pregnancy including fulminant hepatic failure, fetal loss, premature birth, and neonatal mortality, although the underlying mechanisms remain largely unclear. In this study, we first demonstrated that HEV-1 robustly infects pregnant gerbils and causes pregnancy-associated adverse outcomes, which were recorded in 4/6 HEV-1-infected but only 1/5 in PBS-inoculated pregnant gerbils. Howeve...
• Challenges to sustainable large- scale shale gas development in China AI翻译
  作者：Wu, Jian; Tan, Jingqiang; Xu, Jinqi; Li, Lei; Beroza, Gregory C.; Mumford, Kevin G.; van de Ven, Cole; Chen, Baixi; Elsworth, Derek
  作者单位：Central South University; University of Sydney; Central South University; Stanford University; Queens University - Canada; Carleton University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：China's shale gas production has grown annually by 21% since 2017 with long-term national energy strategy calling for continued expansion. This large-scale shale gas development is challenged by constraints on water supply. It requires over 6,000 new wells to be drilled within the Yangtze River Basin in South China-one of China's most populated regions with sensitive ecological and geological conditions, posing significant environmental threats to the hydrosphere, atmosphere, and biosphere. Hy...