2023

最新文章

• How art improves my science AI翻译
  作者：Robison, Amy
  作者单位：Duke University
• From language development to language evolution: A unified view of human lexical creativity AI翻译
  作者：Brochhagen, Thomas; Boleda, Gemma; Gualdoni, Eleonora; Xu, Yang
  作者单位：Pompeu Fabra University; ICREA; University of Toronto
  摘要：A defining property of human language is the creative use of words to express multiple meanings through word meaning extension. Such lexical creativity is manifested at different timescales, ranging from language development in children to the evolution of word meanings over history. We explored whether different manifestations of lexical creativity build on a common foundation. Using computational models, we show that a parsimonious set of semantic knowledge types characterize developmental d...
• Head of US pandemic unit named AI翻译
  作者：Brainard, Jeffrey
• TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease AI翻译
  作者：Zhang, Zi-Yang; Harischandra, Dilshan S.; Wang, Ruifang; Ghaisas, Shivani; Zhao, Janet Y.; McMonagle, Thomas P.; Zhu, Guixin; Lacuarta, Kenzo D.; Song, Jianing; Trojanowski, John Q.; Xu, Hong; Lee, Virginia M. Y.; Yang, Xiaolu
  作者单位：University of Pennsylvania; University of Pennsylvania; Northwestern University; Zhejiang University
  摘要：Aggregation of tau into filamentous inclusions underlies Alzheimer's disease (AD) and numerous other neurodegenerative tauopathies. The pathogenesis of tauopathies remains unclear, which impedes the development of disease-modifying treatments. Here, by systematically analyzing human tripartite motif (TRIM) proteins, we identified a few TRIMs that could potently inhibit tau aggregation. Among them, TRIM11 was markedly down-regulated in AD brains. TRIM11 promoted the proteasomal degradation of m...
• US agency bars Wuhan lab funding AI翻译
  作者：Brainard, Jeffrey
• DEMOCRACY INTERCEPTED AI翻译
  作者：Uzogara, Ekeoma E.
• Climbing fiber multi-innervation of mouse Purkinje dendrites with arborization common to human AI翻译
  作者：Busch, Silas E.; Hansel, Christian
  作者单位：University of Chicago; University of Chicago
  摘要：Canonically, each Purkinje cell (PC) in the adult cerebellum receives only one climbing fiber (CF) from the inferior olive. Underlying current theories of cerebellar function is the notion that this highly conserved one-to-one relationship renders Purkinje dendrites into a single computational compartment. However, we discovered that multiple primary dendrites are a near-universal morphological feature in humans. Using tract tracing, immunolabeling, and in vitro electrophysiology, we found tha...
• US Supreme Court opinion harms watersheds AI翻译
  作者：Sullivan, S. Mazeika Patricio; Gardner, Royal C.
  作者单位：Clemson University; Stetson University
• The Underworld: Journeys to the Depths of the Ocean AI翻译
  作者：Cordes, Erik
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University
• Comment on Ultrastructure reveals ancestral vertebrate pharyngeal skeleton in yunnanozoans AI翻译
  作者：He, Kaiyue; Liu, Jianni; Han, Jian; Ou, Qiang; Chen, Ailin; Zhang, Zhifei; Fu, Dongjing; Hua, Hong; Zhang, Xingliang; Shu, Degan
  作者单位：China University of Geosciences; Yuxi Normal University
  摘要：Tian et al. (Research Articles, 8 July 2022, abm2708) hypothesized that yunnanozoans are stem-group vertebrates on the basis of cellular cartilage, fibrillin microfibers, and subchordal rod associated with the branchial arches of yunnanozoans. However, we reject the presence of cellular cartilage, fibrillin, and the phylogenetic proposal of vertebrate affinities based on ultrastructure and morphology of yunnanozoans from more than 8000 specimens.