作者：Warren, Matthew; Price, Michael
作者：Ferrante, Lucas
作者单位：Universidade Federal de Amazonas
作者：Liu, Bingxu; Carlson, Rebecca J.; Pires, Ivan S.; Gentili, Matteo; Feng, Ellie; Hellier, Quentin; Schwartz, Marc A.; Blainey, Paul C.; Irvine, Darrell J.; Hacohen, Nir
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：Proton leakage from organelles is a common signal for noncanonical light chain 3B (LC3B) lipidation and inflammasome activation, processes induced upon stimulator of interferon genes (STING) activation. On the basis of structural analysis, we hypothesized that human STING is a proton channel. Indeed, we found that STING activation induced a pH increase in the Golgi and that STING reconstituted in liposomes enabled transmembrane proton transport. Compound 53 (C53), a STING agonist that binds th...
作者：Huang, Wei; Rodrigues, Janneth; Bilgo, Etienne; Tormo, Jose R.; Challenger, Joseph D.; De Cozar-Gallardo, Cristina; Perez-Victoria, Ignacio; Reyes, Fernando; Castaneda-Casado, Pablo; Gnambani, Edounou Jacques; Hien, Domonbabele Francois de Sales; Konkobo, Maurice; Urones, Beatriz; Coppens, Isabelle; Mendoza-Losana, Alfonso; Ballell, Lluis; Diabate, Abdoulaye; Churcher, Thomas S.; Jacobs-Lorena, Marcelo
作者单位：Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; GlaxoSmithKline; Imperial College London; GlaxoSmithKline; Universidad Carlos III de Madrid; Johnson & Johnson; Janssen Pharmaceuticals; Johson & Johnson Belgium
摘要：Malaria control demands the development of a wide range of complementary strategies. We describe the properties of a naturally occurring, non-genetically modified symbiotic bacterium, Delftia tsuruhatensis TC1, which was isolated from mosquitoes incapable of sustaining the development of Plasmodium falciparum parasites. D. tsuruhatensis TC1 inhibits early stages of Plasmodium development and subsequent transmission by the Anopheles mosquito through secretion of a small-molecule inhibitor. We h...
作者：Phillips, Aaron
作者单位：University of Calgary; Libin Cardiovascular Institute Of Alberta; University of Calgary
