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作者：Bressan, Dario; Battistoni, Giorgia; Hannon, Gregory J.
作者单位：Cancer Research UK; CRUK Cambridge Institute; University of Cambridge
摘要：BACKGROUNDJust as single-cell sequencing has revolutionized many fields of biology, spatial omics, in which molecular parameters are measured in situ on intact tissue samples, is set to empower a new generation of scientific discoveries. A plethora of new technologies now enable spatial profiling of gene and protein expression, genetic mutations, epigenetic marks, chromatin structure, and genome organization. Most of these methods trace back to traditional techniques such as immunohistochemist...
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作者：Kalyuzhny, Michael; Lake, Jeffrey K.; Wright, S. Joseph; Ostling, Annette M.
作者单位：University of Texas System; University of Texas Austin; University of Michigan System; University of Michigan; Smithsonian Institution; Smithsonian Tropical Research Institute; University of Texas System; University of Texas Austin
摘要：For species to coexist, performance must decline as the density of conspecific individuals increases. Although evidence for such conspecific negative density dependence (CNDD) exists in forests, the within-species spatial repulsion it should produce has rarely been demonstrated in adults. In this study, we show that in comparison to a null model of stochastic birth, death, and limited dispersal, the adults of dozens of tropical forest tree species show strong spatial repulsion, some to surpris...
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作者：Voosen, Paul
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作者：Jackson, Fatimah L. C.
作者单位：Howard University
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作者：Lin, Woan-Yu; Iliev, Iliyan D.
作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine
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作者：Su, Songkun; Giurfa, Martin
作者单位：Fujian Agriculture & Forestry University; Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Institut Universitaire de France
摘要：In a technical comment, Barron et al. (1) criticized the work of Huang et al. (2) putting the accent on the quantification of dopamine levels via high-performance liquid chromatography (HPLC), yet also including data interpretation through alternative hypotheses aimed at invalidating the original ones proposed by Huang et al. We thank the authors of this technical comment, which allows us to clarify technical aspects of our work that may have been unclear, and for promoting discussion around t...
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作者：Wang, Kai; Zhang, Zhiwei; Hang, Jing; Liu, Jia; Guo, Fusheng; Ding, Yong; Li, Meng; Nie, Qixing; Lin, Jun; Zhuo, Yingying; Sun, Lulu; Luo, Xi; Zhong, Qihang; Ye, Chuan; Yun, Chuyu; Zhang, Yi; Wang, Jue; Bao, Rui; Pang, Yanli; Wang, Guang; Gonzalez, Frank J.; Lei, Xiaoguang; Qiao, Jie; Jiang, Changtao
作者单位：Peking University; Peking University; Capital Medical University; Peking University; Peking University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Sichuan University; Peking University
摘要：A mechanistic understanding of how microbial proteins affect the host could yield deeper insights into gut microbiota-host cross-talk. We developed an enzyme activity-screening platform to investigate how gut microbiota-derived enzymes might influence host physiology. We discovered that dipeptidyl peptidase 4 (DPP4) is expressed by specific bacterial taxa of the microbiota. Microbial DPP4 was able to decrease the active glucagon like peptide-1 (GLP-1) and disrupt glucose metabolism in mice wit...
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作者：Kim, Christina K.
作者单位：University of California System; University of California Davis; University of California System; University of California Davis
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作者：Pierre, Joseph F.; Peters, Brian M.; La Torre, Diana; Sidebottom, Ashley M.; Tao, Yun; Zhu, Xiaorong; Cham, Candace M.; Wang, Ling; Kambal, Amal; Harris, Katharine G.; Silva, Julian F.; Zaborina, Olga; Alverdy, John C.; Herzog, Herbert; Witchley, Jessica; Noble, Suzanne M.; Leone, Vanessa A.; Chang, Eugene B.
作者单位：University of Chicago; University of Wisconsin System; University of Wisconsin Madison; University of Tennessee System; University of Tennessee Health Science Center; University of Chicago; Garvan Institute of Medical Research; University of California System; University of California San Francisco; University of California System; University of California Berkeley; University of Wisconsin System; University of Wisconsin Madison
摘要：The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility whereas others regulate the microbiota. We have found that peptide YY (PYY1-36), but not endocrine PYY3-36, acts as an antimicrobial peptide (AMP) expressed by gut epithelial paneth cells (PC). PC-PYY is packaged into secretory granules and is secreted into and retained by surface mucus, which optimizes PC-PYY activity. Although PC-PYY shows some antibacterial activity, it ...
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作者：Yang, Hong; Xiang, Xiaohua; Wu, Xiaoling; Thompson, Julian R.; Flower, Roger J.
作者单位：University of Reading; Hohai University; University of London; University College London
