2023

最新文章

• Action needed to make carbon offsets from forest conservation work for climate change mitigation AI翻译
  作者：West, Thales A. P.; Wunder, Sven; Sills, Erin O.; Boerner, Jan; Rifai, Sami W.; Neidermeier, Alexandra N.; Frey, Gabriel P.; Kontoleon, Andreas
  作者单位：Vrije Universiteit Amsterdam; University of Cambridge; CGIAR; Center for International Forestry Research (CIFOR); North Carolina State University; University of Bonn; University of Bonn; University of New South Wales Sydney; University of Cambridge
  摘要：Carbon offsets from voluntary avoided-deforestation projects are generated on the basis of performance in relation to ex ante deforestation baselines. We examined the effects of 26 such project sites in six countries on three continents using synthetic control methods for causal inference. We found that most projects have not significantly reduced deforestation. For projects that did, reductions were substantially lower than claimed. This reflects differences between the project ex ante baseli...
• The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation AI翻译
  作者：Gu, Xin; Nardone, Christopher; Kamitaki, Nolan; Mao, Aoyue; Elledge, Stephen J.; Greenberg, Michael E.
  作者单位：Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University
  摘要：Cells use ubiquitin to mark proteins for proteasomal degradation. Although the proteasome also eliminates proteins that are not ubiquitinated, how this occurs mechanistically is unclear. Here, we found that midnolin promoted the destruction of many nuclear proteins, including transcription factors encoded by the immediate-early genes. Diverse stimuli induced midnolin, and its overexpression was sufficient to cause the degradation of its targets by a mechanism that did not require ubiquitinatio...
• Alcanivorax borkumensis biofilms enhance oil degradation by interfacial tubulation AI翻译
  作者：Prasad, M.; Obana, N.; Lin, S. -Z.; Zhao, S.; Sakai, K.; Blanch-Mercader, C.; Prost, J.; Nomura, N.; Rupprecht, J. -F.; Fattaccioli, J.; Utada, A. S.
  作者单位：University of Tsukuba; University of Tsukuba; University of Tsukuba; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Aix-Marseille Universite; Sorbonne Universite; Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); Universite PSL; UNICANCER; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; CNRS - Institute of Chemistry (INC); National University of Singapore; University of Tsukuba; University of Sheffield
  摘要：During the consumption of alkanes, Alcanivorax borkumensis will form a biofilm around an oil droplet, but the role this plays during degradation remains unclear. We identified a shift in biofilm morphology that depends on adaptation to oil consumption: Longer exposure leads to the appearance of dendritic biofilms optimized for oil consumption effected through tubulation of the interface. In situ microfluidic tracking enabled us to correlate tubulation to localized defects in the interfacial ce...
• Yolk sac cell atlas reveals multiorgan functions during human early development AI翻译
  作者：Goh, Issac; Botting, Rachel A.; Rose, Antony; Webb, Simone; Engelbert, Justin; Gitton, Yorick; Stephenson, Emily; Quiroga Londono, Mariana; Mather, Michael; Mende, Nicole; Imaz-Rosshandler, Ivan; Yang, Lu; Horsfall, Dave; Basurto-Lozada, Daniela; Chipampe, Nana-Jane; Rook, Victoria; Lee, Jimmy Tsz Hang; Ton, Mai-Linh; Keitley, Daniel; Mazin, Pavel; Vijayabaskar, M. S.; Hannah, Rebecca; Gambardella, Laure; Green, Kile; Ballereau, Stephane; Inoue, Megumi; Tuck, Elizabeth; Lorenzi, Valentina; Kwakwa, Kwasi; Alsinet, Clara; Olabi, Bayanne; Miah, Mohi; Admane, Chloe; Popescu, Dorin-Mirel; Acres, Meghan; Dixon, David; Ness, Thomas; Coulthard, Rowen; Lisgo, Steven; Henderson, Deborah J.; Dann, Emma; Suo, Chenqu; Kinston, Sarah J.; Park, Jong-eun; Polanski, Krzysztof; Marioni, John; van Dongen, Stijn; Meyer, Kerstin B.; de Bruijn, Marella; Palis, James; Behjati, Sam; Laurenti, Elisa; Wilson, Nicola K.; Vento-Tormo, Roser; Chedotal, Alain; Bayraktar, Omer; Roberts, Irene; Jardine, Laura; Goettgens, Berthold; Teichmann, Sarah A.; Haniffa, Muzlifah
  作者单位：Wellcome Trust Sanger Institute; Newcastle University - UK; Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); MRC Laboratory Molecular Biology; University of Cambridge; Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University - UK; Korea Advanced Institute of Science & Technology (KAIST); European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; CRUK Cambridge Institute; University of Cambridge; University of Oxford; University of Rochester; University of Cambridge; University of Oxford; University of Cambridge; Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust
  摘要：The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation, vascular development, and hematopoietic regulation. We reconstructed the emergence ...
• India creates research funder AI翻译
  作者：Brainard, Jeffrey
• Pre-Younger Dryas megafaunal extirpation at Rancho La Brea linked to fire-driven state shift AI翻译
  作者：O'Keefe, F. Robin; Dunn, Regan E.; Weitzel, Elic M.; Waters, Michael R.; Martinez, Lisa N.; Binder, Wendy J.; Southon, John R.; Cohen, Joshua E.; Meachen, Julie A.; Desantis, Larisa R. G.; Kirby, Matthew E.; Ghezzo, Elena; Coltrain, Joan B.; Fuller, Benjamin T.; Farrell, Aisling B.; Takeuchi, Gary T.; Macdonald, Glen; Davis, Edward B.; Lindsey, Emily L.
  作者单位：Marshall University; University of Southern California; University of Connecticut; Texas A&M University System; Texas A&M University College Station; University of California System; University of California Los Angeles; Loyola Marymount University; University of California System; University of California Irvine; Pace University; Des Moines University; Vanderbilt University; Vanderbilt University; California State University System; California State University Fullerton; Universita Ca Foscari Venezia; University of Oregon; Utah System of Higher Education; University of Utah; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Institut de Recherche pour le Developpement (IRD); University of California System; University of California Los Angeles
  摘要：The cause, or causes, of the Pleistocene megafaunal extinctions have been difficult to establish, in part because poor spatiotemporal resolution in the fossil record hinders alignment of species disappearances with archeological and environmental data. We obtained 172 new radiocarbon dates on megafauna from Rancho La Brea in California spanning 15.6 to 10.0 thousand calendar years before present (ka). Seven species of extinct megafauna disappeared by 12.9 ka, before the onset of the Younger Dr...
• Extracting resources from abandoned mines AI翻译
  作者：Bao, Zhongwen; Ptacek, Carol J.; Blowes, David W.
  作者单位：University of Waterloo
• After string of failures, Japan aims to launch x-ray telescope AI翻译
  作者：Clery, Daniel
  摘要：Groundbreaking XRISM will capture spectra, revealing the motion and composition of million-degree gases
• Create a culture of experiments in environmental programs AI翻译
  作者：Ferraro, Paul J.; Cherry, Todd L.; Shogren, Jason F.; Vossler, Christian A.; Cason, Timothy N.; Flint, Hilary Byerly; Hochard, Jacob P.; Johansson-Stenman, Olof; Martinsson, Peter; Murphy, James J.; Newbold, Stephen C.; Thunstroem, Linda; van Soest, Daan; van 't Veld, Klaas; Dannenberg, Astrid; Loewenstein, George F.; van Boven, Leaf
  作者单位：Johns Hopkins University; Johns Hopkins University; University of Wyoming; University of Tennessee System; University of Tennessee Knoxville; Purdue University System; Purdue University; University of Wyoming; University of Gothenburg; Technical University of Denmark; University of Alaska System; University of Alaska Anchorage; Tilburg University; Universitat Kassel; Carnegie Mellon University; University of Colorado System; University of Colorado Boulder
• Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS AI翻译
  作者：Schulze, Christopher J.; Seamon, Kyle J.; Zhao, Yulei; Yang, Yu C.; Cregg, Jim; Kim, Dongsung; Tomlinson, Aidan; Choy, Tiffany J.; Wang, Zhican; Sang, Ben; Pourfarjam, Yasin; Lucas, Jessica; Cuevas-Navarro, Antonio; Ayala-Santos, Carlos; Vides, Alberto; Li, Chuanchuan; Marquez, Abby; Zhong, Mengqi; Vemulapalli, Vidyasiri; Weller, Caroline; Gould, Andrea; Whalen, Daniel M.; Salvador, Anthony; Milin, Anthony; Saldajeno-Concar, Mae; Dinglasan, Nuntana; Chen, Anqi; Evans, Jim; Knox, John E.; Koltun, Elena S.; Singh, Mallika; Nichols, Robert; Wildes, David; Gill, Adrian L.; Smith, Jacqueline A. M.; Lito, Piro
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine
  摘要：The discovery of small-molecule inhibitors requires suitable binding pockets on protein surfaces. Proteins that lack this feature are considered undruggable and require innovative strategies for therapeutic targeting. KRAS is the most frequently activated oncogene in cancer, and the active state of mutant KRAS is such a recalcitrant target. We designed a natural product-inspired small molecule that remodels the surface of cyclophilin A (CYPA) to create a neomorphic interface with high affinity...