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作者：Li, Zhongbin B.; Zhang, Yongjun; Wang, Mengqiu
作者单位：Wuhan University
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作者：Brainard, Jeffrey
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作者：Albin, Einat; Bressler, Shikma; Rolls, Asya; Schwartz, Michal; Shapiro, Ehud
作者单位：Hebrew University of Jerusalem; Weizmann Institute of Science; Technion Israel Institute of Technology
摘要：Over the past 30 weeks, Israel has been undergoing an upheaval marked by unprecedented attacks by the government on the independence of its judiciary, attorney general, government legal advisers, police, military, public broadcasting, and religious freedom. This assault on democratic institutions and principles is an imminent threat to Israeli academia, which relies on a solid democratic foundation. In response, universities, academics, and students have emerged as key proponents of ongoing pr...
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作者：Brainard, Jeffrey
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作者：Guan, Fuxin; Guo, Xiangdong; Zeng, Kebo; Zhang, Shu; Nie, Zhaoyu; Ma, Shaojie; Dai, Qing; Pendry, John; Zhang, Xiang; Zhang, Shuang
作者单位：University of Hong Kong; Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; University of California System; University of California Berkeley; Imperial College London; University of Hong Kong; University of Hong Kong; University of Hong Kong
摘要：Superlenses made of plasmonic materials and metamaterials can image features at the subdiffraction scale. However, intrinsic losses impose a serious restriction on imaging resolution, a problem that has hindered widespread applications of superlenses. Optical waves of complex frequency that exhibit a temporally attenuating behavior have been proposed to offset the intrinsic losses in superlenses through the introduction of virtual gain, but experimental realization has been lacking because of ...
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作者：Zhou, Zijing; Ma, Xiaonuo; Lin, Yiechang; Cheng, Delfine; Bavi, Navid; Secker, Genevieve A.; Li, Jinyuan Vero; Janbandhu, Vaibhao; Sutton, Drew L.; Scott, Hamish S.; Yao, Mingxi; Harvey, Richard P.; Harvey, Natasha L.; Corry, Ben; Zhang, Yixiao; Cox, Charles D.
作者单位：Victor Chang Cardiac Research Institute; University of New South Wales Sydney; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Australian National University; University of Chicago; Centre for Cancer Biology; University of South Australia; SA Pathology; University of Adelaide; SA Pathology; Southern University of Science & Technology; University of New South Wales Sydney; University of New South Wales Sydney
摘要：Piezo channels are critical cellular sensors of mechanical forces. Despite their large size, ubiquitous expression, and irreplaceable roles in an ever-growing list of physiological processes, few Piezo channel-binding proteins have emerged. In this work, we found that MyoD (myoblast determination)-family inhibitor proteins (MDFIC and MDFI) are PIEZO1/2 interacting partners. These transcriptional regulators bind to PIEZO1/2 channels, regulating channel inactivation. Using single-particle cryoge...
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作者：Cerullo, Gianluca; Barlow, Jos; Betts, Matthew; Edwards, David; Eyres, Alison; Franca, Filipe; Garrett, Rachael; Swinfield, Thomas; Tew, Eleanor; White, Thomas; Balmford, Andrew
作者单位：University of Cambridge; University of Cambridge; Lancaster University; Oregon State University; University of Sheffield; University of Bristol; University of Cambridge; University of Oxford
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作者：Fleck, Jonas Simon; Camp, J. Gray; Treutlein, Barbara
作者单位：Roche Holding; Swiss Federal Institutes of Technology Domain; ETH Zurich
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作者：Brainard, Jeffrey
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作者：Praetorius, Florian; Leung, Philip J. Y.; Tessmer, Maxx H.; Broerman, Adam; Demakis, Cullen; Dishman, Acacia F.; Pillai, Arvind; Idris, Abbas; Juergens, David; Dauparas, Justas; Li, Xinting; Levine, Paul M.; Lamb, Mila; Ballard, Ryanne K.; Gerben, Stacey R.; Nguyen, Hannah; Kang, Alex; Sankaran, Banumathi; Bera, Asim K.; Volkman, Brian F.; Nivala, Jeff; Stoll, Stefan; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Medical College of Wisconsin; Medical College of Wisconsin; University of Washington; University of Washington Seattle; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute
摘要：In nature, proteins that switch between two conformations in response to environmental stimuli structurally transduce biochemical information in a manner analogous to how transistors control information flow in computing devices. Designing proteins with two distinct but fully structured conformations is a challenge for protein design as it requires sculpting an energy landscape with two distinct minima. Here we describe the design of hinge proteins that populate one designed state in the absen...
