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作者：Lv, Xiangdong; Lu, Xuan; Cao, Jin; Luo, Qin; Ding, Yao; Peng, Fanglue; Pataer, Apar; Lu, Dong; Han, Dong; Malmberg, Eric; Chan, Doug W.; Wang, Xiaoran; Savage, Sara R.; Mao, Sufeng; Yu, Jingjing; Peng, Fei; Yan, Liang; Meng, Huan; Maneix, Laure; Han, Yumin; Chen, Yiwen; Yao, Wantong; Chang, Eric C.; Catic, Andre; Lin, Xia; Miles, George; Huang, Pengxiang; Sun, Zheng; Burt, Bryan; Wang, Huamin; Wang, Jin; Yao, Qizhi Cathy; Zhang, Bing; Roth, Jack A.; O'Malley, Bert W.; Ellis, Matthew J.; Rimawi, Mothaffar F.; Ying, Haoqiang; Chen, Xi
作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Baylor College of Medicine; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; AstraZeneca
摘要：Despite substantial advances in targeting mutant KRAS, tumor resistance to KRAS inhibitors (KRASi) remains a major barrier to progress. Here, we report proteostasis reprogramming as a key convergence point of multiple KRASi-resistance mechanisms. Inactivation of oncogenic KRAS down-regulated both the heat shock response and the inositol-requiring enzyme 1a (IRE1a) branch of the unfolded protein response, causing severe proteostasis disturbances. However, IRE1a was selectively reactivated in an...
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作者：Karath, Kata
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作者：Kramer, Laird; Fuller, Edgar; Watson, Charity; Castillo, Adam; Oliva, Pablo Duran; Potvin, Geoff
作者单位：State University System of Florida; Florida International University; State University System of Florida; Florida International University; State University System of Florida; Florida International University; State University System of Florida; Florida International University; Virginia Commonwealth University
摘要：Calculus, the study of change in processes and systems, serves as the foundation for many STEM disciplines. Traditional, lecture-based calculus instruction may present a barrier for students seeking STEM degrees, limit their access to STEM professions, and block their potential to address society's challenges. A large-scale pragmatic trial with randomized student allocation was conducted to compare two calculus instruction styles: active student engagement (treatment condition) versus traditio...
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作者：[Anonymous]
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作者：Brainard, Jeffrey
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作者：Tessier-Lavigne, Marc
作者单位：Stanford University
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作者：You, Bei; Cao, Xinwu; Yan, Zhen; Hameury, Jean-Marie; Czerny, Bozena; Wu, Yue; Xia, Tianyu; Sikora, Marek; Zhang, Shuang-Nan; Du, Pu; Zycki, Piotr T.
作者单位：Wuhan University; Zhejiang University; Chinese Academy of Sciences; Shanghai Astronomical Observatory, CAS; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Polish Academy of Sciences; Center for Theoretical Physics - Polish Academy of Sciences; Nanjing University; Nanjing University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Polish Academy of Sciences; Nicolaus Copernicus Astronomical Center of the Polish Academy of Sciences; Chinese Academy of Sciences; Institute of High Energy Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：Accretion of material onto a black hole drags any magnetic fields present inwards, increasing their strength. Theory predicts that sufficiently strong magnetic fields can halt the accretion flow, producing a magnetically arrested disk (MAD). We analyzed archival multiwavelength observations of an outburst from the black hole x-ray binary MAXI J1820+070 in 2018. The radio and optical fluxes were delayed compared with the x-ray flux by about 8 and 17 days, respectively. We interpret this as evid...
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作者：Rinehart, N. Ian; Saunthwal, Rakesh K.; Wellauer, Joel; Zahrt, Andrew F.; Schlemper, Lukas; Shved, Alexander S.; Bigler, Raphael; Fantasia, Serena; Denmark, Scott E.
作者单位：University of Illinois System; University of Illinois Urbana-Champaign
摘要：Machine-learning methods have great potential to accelerate the identification of reaction conditions for chemical transformations. A tool that gives substrate-adaptive conditions for palladium (Pd)-catalyzed carbon-nitrogen (C-N) couplings is presented. The design and construction of this tool required the generation of an experimental dataset that explores a diverse network of reactant pairings across a set of reaction conditions. A large scope of C-N couplings was actively learned by neural...
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作者：Zou, Yimin; Poo, Mu-Ming; Tessier-Lavigne, Marc
作者单位：University of California System; University of California San Diego; Chinese Academy of Sciences; Stanford University
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作者：Lee, Brian K.; Mayhew, Emily J.; Sanchez-Lengeling, Benjamin; Wei, Jennifer N.; Qian, Wesley W.; Little, Kelsie A.; Andres, Matthew; Nguyen, Britney B.; Moloy, Theresa; Yasonik, Jacob; Parker, Jane K.; Gerkin, Richard C.; Mainland, Joel D.; Wiltschko, Alexander B.
作者单位：Alphabet Inc.; Google Incorporated; Monell Chemical Senses Center; Michigan State University; University of Illinois System; University of Illinois Urbana-Champaign; University of Reading; Arizona State University; Arizona State University-Tempe; University of Pennsylvania
摘要：Mapping molecular structure to odor perception is a key challenge in olfaction. We used graph neural networks to generate a principal odor map (POM) that preserves perceptual relationships and enables odor quality prediction for previously uncharacterized odorants. The model was as reliable as a human in describing odor quality: On a prospective validation set of 400 out-of-sample odorants, the model-generated odor profile more closely matched the trained panel mean than did the median panelis...
