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作者:Jia, Zhe; Jin, Zeyu; Marchandon, Mathilde; Ulrich, Thomas; Gabriel, Alice-Agnes; Fan, Wenyuan; Shearer, Peter; Zou, Xiaoyu; Rekoske, John; Bulut, Fatih; Garagon, Asli; Fialko, Yuri
作者单位:University of California System; University of California San Diego; Scripps Institution of Oceanography; University of Munich; Bogazici University
摘要:The destructive 2023 moment magnitude (M-w) 7.8-7.7 earthquake doublet ruptured multiple segments of the East Anatolian Fault system in Turkey. We integrated multiscale seismic and space-geodetic observations with multifault kinematic inversions and dynamic rupture modeling to unravel the events' complex rupture history and stress-mediated fault interactions. Our analysis reveals three subshear slip episodes during the initial M-w 7.8 earthquake with a delayed rupture initiation to the southwe...
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作者:Hoelzel, A. Rus; Lynch, Michael
作者单位:Durham University; Arizona State University; Arizona State University-Tempe
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作者:Mervis, Jeffrey
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作者:Xia, Siyou; Yang, Yu; Liu, Yi; Poon, Jessie
作者单位:Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; State University of New York (SUNY) System; University at Buffalo, SUNY
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作者:Dai, Wen; Zhang, Heng; Lund, Hayley; Zhang, Ziyu; Castleberry, Mark; Rodriguez, Maya; Kuriakose, George; Gupta, Sweta; Lewandowska, Magdalena; Powers, Hayley R.; Valmiki, Swati; Zhu, Jieqing; Shapiro, Amy D.; Hussain, M. Mahmood; Lopez, Jose A.; Sorci-Thomas, Mary G.; Silverstein, Roy L.; Ginsberg, Henry N.; Sahoo, Daisy; Tabas, Ira; Zheng, Ze
作者单位:Medical College of Wisconsin; Marquette University; NewYork-Presbyterian Hospital; Columbia University; Indiana Hemophilia & Thrombosis Center; Medical College of Wisconsin; State University of New York (SUNY) System; SUNY Downstate Health Sciences University; University of Washington; University of Washington Seattle; Medical College of Wisconsin; Medical College of Wisconsin; Columbia University; NewYork-Presbyterian Hospital; Columbia University; NewYork-Presbyterian Hospital; Columbia University; Medical College of Wisconsin
摘要:INTRODUCTION: Tissue plasminogen activator (tPA) is a serine protease that initiates fibrinolysis to remove excessive blood clots and restore blood flow. Intravenous infusion of recombinant tPA is approved as a thrombolytic therapy in thrombotic cardiovascular diseases, including ischemic stroke and myocardial infarction. Low plasma tPA activity is associated with a higher risk of atherosclerotic cardiovascular disease and atherogenic apolipoprotein B (apoB)-lipoprotein cholesterol levels in h...
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作者:Firestein, Stuart
作者单位:Columbia University; The Santa Fe Institute
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作者:Grimm, David
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作者:Hu, Wangjie; Hao, Ziqian; Du, Pengyuan; Di Vincenzo, Fabio; Manzi, Giorgio; Cui, Jialong; Fu, Yun-Xin; Pan, Yi-Hsuan; Li, Haipeng
作者单位:Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Institute of Nutrition & Health, CAS; East China Normal University; Shandong First Medical University & Shandong Academy of Medical Sciences; University of Florence; Sapienza University Rome; University of Texas System; University of Texas Health Science Center Houston; University of Texas School Public Health; Yunnan University; Chinese Academy of Sciences
摘要:Population size history is essential for studying human evolution. However, ancient population size history during the Pleistocene is notoriously difficult to unravel. In this study, we developed a fast infinitesimal time coalescent process (FitCoal) to circumvent this difficulty and calculated the composite likelihood for present-day human genomic sequences of 3154 individuals. Results showed that human ancestors went through a severe population bottleneck with about 1280 breeding individuals...
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作者:Pande, Rohini
作者单位:Yale University
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作者:Suarez-Menendez, Marcos; Berube, Martine; Furni, Fabricio; Rivera-Leon, Vania E.; Heide-Jorgensen, Mads-Peter; Larsen, Finn; Sears, Richard; Ramp, Christian; Eriksson, Britas Klemens; Etienne, Rampal S.; Robbins, Jooke; Palsboll, Per J.
作者单位:University of Groningen; Greenland Institute of Natural Resources; University of St Andrews
摘要:Phylogeny-based estimates suggesting a low germline mutation rate (mu) in baleen whales have influenced research ranging from assessments of whaling impacts to evolutionary cancer biology. We estimated mu directly from pedigrees in four baleen whale species for both the mitochondrial control region and nuclear genome. The results suggest values higher than those obtained through phylogeny-based estimates and similar to pedigree-based values for primates and toothed whales. Applying our estimat...