2023

最新文章

• Fairy circles abound in dry regions of many countries AI翻译
  作者：Brainard, Jeffrey
• Are algorithmic bias claims supported? AI翻译
  作者：Messing, Solomon
  作者单位：New York University
• Aromatic nitrogen scanning by ipso-selective nitrene internalization AI翻译
  作者：Pearson, Tyler J.; Shimazumi, Ryoma; Driscoll, Julia L.; Dherange, Balu D.; Park, Dong-Il; Levin, Mark D.
  作者单位：University of Chicago
  摘要：Nitrogen scanning in aryl fragments is a valuable aspect of the drug discovery process, but current strategies require time-intensive, parallel, bottom-up synthesis of each pyridyl isomer because of a lack of direct carbon-to-nitrogen (C-to-N) replacement reactions. We report a site-directable aryl C-to-N replacement reaction allowing unified access to various pyridine isomers through a nitreneinternalization process. In a two-step, one-pot procedure, aryl azides are first photochemically conv...
• Mars Sample Return gets a new price tag. It's big AI翻译
  作者：Voosen, Paul
• EU eyes extending glyphosate use AI翻译
  作者：Brainard, Jeffrey
• LURKING IN THE DEEP FREEZE? Climate change may release dangerous pathogens frozen for centuries in Arctic permafrost AI翻译
  作者：Cohen, Jon
• Valley-addressable monolayer lasing through spin-controlled Berry phase photonic cavities AI翻译
  作者：Duan, Xiaoyang; Wang, Bo; Rong, Kexiu; Liu, Chieh-Li; Gorovoy, Vladi; Mukherjee, Subhrajit; Kleiner, Vladimir; Koren, Elad; Hasman, Erez
  作者单位：Technion Israel Institute of Technology; Technion Israel Institute of Technology; Shanghai Jiao Tong University; Technion Israel Institute of Technology
  摘要：The spin-valley coupling between circularly polarized light and valley excitons in transition metal dichalcogenides provides the opportunity to generate and manipulate spin information by exploiting the valley degree of freedom. Here, we demonstrate a room-temperature valley-addressable tungsten disulfide monolayer laser in which the spin of lasing is controlled by the spin of pump without magnetic fields. This effect was achieved by integrating a tungsten disulfide monolayer into a photonic c...
• Gulls, floods, and superbugs AI翻译
  作者：Cohen, Jon
• Genomic signatures of disease resistance in endangered staghorn corals AI翻译
  作者：Vollmer, Steven V.; Selwyn, Jason D.; Despard, Brecia A.; Roesel, Charles L.
  作者单位：Northeastern University
  摘要：White band disease (WBD) has caused unprecedented declines in the Caribbean Acropora corals, which are now listed as critically endangered species. Highly disease-resistant Acropora cervicornis genotypes exist, but the genetic underpinnings of disease resistance are not understood. Using transmission experiments, a newly assembled genome, and whole-genome resequencing of 76 A. cervicornis genotypes from Florida and Panama, we identified 10 genomic regions and 73 single-nucleotide polymorphisms...
• Fibroblasts in heart scar tissue directly regulate cardiac excitability and arrhythmogenesis AI翻译
  作者：Wang, Yijie; Li, Qihao; Tao, Bo; Angelini, Marina; Ramadoss, Sivakumar; Sun, Baiming; Wang, Ping; Krokhaleva, Yuliya; Ma, Feiyang; Gu, Yiqian; Espinoza, Alejandro; Yamauchi, Ken; Pellegrini, Matteo; Novitch, Bennett; Olcese, Riccardo; Qu, Zhilin; Song, Zhen; Deb, Arjun
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Peng Cheng Laboratory; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Northwestern University; Feinberg School of Medicine; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
  摘要：After heart injury, dead heart muscle is replaced by scar tissue. Fibroblasts can electrically couple with myocytes, and changes in fibroblast membrane potential can lead to myocyte excitability, which suggests that fibroblast-myocyte coupling in scar tissue may be responsible for arrhythmogenesis. However, the physiologic relevance of electrical coupling of myocytes and fibroblasts and its impact on cardiac excitability in vivo have never been demonstrated. We genetically engineered a mouse t...