作者：Buller, R.; Lutz, S.; Kazlauskas, R. J.; Snajdrova, R.; Moore, J. C.; Bornscheuer, U. T.
作者单位：Zurich University of Applied Sciences; University of Minnesota System; University of Minnesota Twin Cities; Novartis; Merck & Company; Merck & Company USA
摘要：Biocatalysis harnesses enzymes to make valuable products. This green technology is used in countless applications from bench scale to industrial production and allows practitioners to access complex organic molecules, often with fewer synthetic steps and reduced waste. The last decade has seen an explosion in the development of experimental and computational tools to tailor enzymatic properties, equipping enzyme engineers with the ability to create biocatalysts that perform reactions not prese...
作者：Henneman, Lucas; Choirat, Christine; Dedoussi, Irene; Dominici, Francesca; Roberts, Jessica; Zigler, Corwin
作者单位：George Mason University; Harvard University; Harvard T.H. Chan School of Public Health; University of Geneva; Swiss School of Public Health (SSPH+); Delft University of Technology; University System of Georgia; Georgia Institute of Technology; University of Texas System; University of Texas Austin
摘要：Policy-makers seeking to limit the impact of coal electricity-generating units (EGUs, also known as power plants) on air quality and climate justify regulations by quantifying the health burden attributable to exposure from these sources. We defined coal PM2.5 as fine particulate matter associated with coal EGU sulfur dioxide emissions and estimated annual exposure to coal PM2.5 from 480 EGUs in the US. We estimated the number of deaths attributable to coal PM2.5 from 1999 to 2020 using indivi...
作者：Abbasi, R. U.; Allen, M. G.; Arimura, R.; Belz, J. W.; Bergman, D. R.; Blake, S. A.; Shin, B. K.; Buckland, I. J.; Cheon, B. G.; Fujii, T.; Fujisue, K.; Fujita, K.; Fukushima, M.; Furlich, G. D.; Gerber, Z. R.; Globus, N.; Hibino, K.; Higuchi, R.; Honda, K.; Ikeda, D.; Ito, H.; Iwasaki, A.; Jeong, S.; Jeong, H. M.; Jui, C. H.; Kadota, K.; Kakimoto, F.; Kalashev, O. E.; Kasahara, K.; Kawata, K.; Kharuk, I.; Kido, E.; Kim, S. W.; Kim, H. B.; Kim, J. H.; Kim, J. H.; Komae, I.; Kubota, Y.; Kuznetsov, M. Y.; Lee, K. H.; Lubsandorzhiev, B. K.; Lundquist, J. P.; Matthews, J. N.; Nagataki, S.; Nakamura, T.; Nakazawa, A.; Nonaka, T.; Ogio, S.; Ono, M.; Oshima, H.; Park, I. H.; Potts, M.; Pshirkov, S.; Remington, J. R.; Rodriguez, D. C.; Rott, C.; Rubtsov, G. I.; Ryu, D.; Sagawa, H.; Sakaki, N.; Sako, T.; Sakurai, N.; Shin, H.; Smith, J. D.; Sokolsky, P.; Stokes, B. T.; Stroman, T. S.; Takahashi, K.; Takeda, M.; Taketa, A.; Tameda, Y.; Thomas, S.; Thomson, G. B.; Tinyakov, P. G.; Tkachev, I.; Tomida, T.; Troitsky, S. V.; Tsunesada, Y.; Udo, S.; Urban, F. R.; Wong, T.; Yamazaki, K.; Yuma, Y.; Zhezher, Y. V.; Zundel, Z.
作者单位：Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Osaka Metropolitan University; Ulsan National Institute of Science & Technology (UNIST); Hanyang University; Hanyang University; Kyoto University; Kyoto University; Osaka Metropolitan University; University of Tokyo; RIKEN; Kanagawa University; University of Yamanashi; Sungkyunkwan University (SKKU); Tokyo City University; Russian Academy of Sciences; Institute for Nuclear Research of the Russian Academy of Sciences; United States Department of Energy (DOE); Argonne National Laboratory; Shinshu University; University of Nova Gorica; Academia Sinica - Taiwan; National Aeronautics & Space Administration (NASA); University of Tokyo; Osaka Electro-Communication University; Universite Libre de Bruxelles; Czech Academy of Sciences; Institute of Physics of the Czech Academy of Sciences; Chubu University
摘要：Cosmic rays are energetic charged particles from extraterrestrial sources, with the highest-energy events thought to come from extragalactic sources. Their arrival is infrequent, so detection requires instruments with large collecting areas. In this work, we report the detection of an extremely energetic particle recorded by the surface detector array of the Telescope Array experiment. We calculate the particle's energy as 244 +/- 29 (stat.)(-76)(+51) (syst.) exa-electron volts (similar to 40 ...
作者：Selva, Nuria; Bautista, Carlos; Fernandez-Gil, Alberto; de Gabriel Hernando, Miguel; Garcia-Rodriguez, Alberto; Naves, Javier; Calzada, Javier; Diaz-Fernandez, Manuel; Diaz-Vaquero, Vanessa; Leonard, Jennifer A.; Morales-Gonzalez, Ana; Naves-Alegre, Lara; Quevedo, Mario; Salado, Isabel; Vila, Carles; Revilla, Eloy
作者单位：Polish Academy of Sciences; Universidad de Huelva; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); Universidad de Leon; Consejo Superior de Investigaciones Cientificas (CSIC); University of Oviedo; Universitat d'Alacant
作者：Yang, Sichen; Palmquist, Karl H.; Nathan, Levy; Pfeifer, Charlotte R.; Schultheiss, Paula J.; Sharma, Anurag; Kam, Lance C.; Miller, Pearson W.; Shyer, Amy E.; Rodrigues, Alan R.
作者单位：Rockefeller University; Columbia University; Columbia University; Rockefeller University; Simons Foundation; Flatiron Institute
摘要：During vertebrate organogenesis, increases in morphological complexity are tightly coupled to morphogen expression. In this work, we studied how morphogens influence self-organizing processes at the collective or supra-cellular scale in avian skin. We made physical measurements across length scales, which revealed morphogen-enabled material property differences that were amplified at supracellular scales in comparison to cellular scales. At the supracellular scale, we found that fibroblast gro...
