作者：Moore, Jonathan W.; Pitman, Kara J.; Whited, Diane; Marsden, Naxginkw Tara; Sexton, Erin K.; Sergeant, Christopher J.; Connor, Mark
作者单位：Simon Fraser University; University of Montana System; University of Montana
作者：Turner, Michael S.
作者单位：University of Chicago; University of California System; University of California Los Angeles
作者：Wai, Jonathan; Wai, Maya
作者单位：University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Medical Sciences
作者：Altae-Tran, Han; Kannan, Soumya; Suberski, Anthony J.; Mears, Kepler S.; Demircioglu, F. Esra; Moeller, Lukas; Kocalar, Selin; Oshiro, Rachel; Makarova, Kira S.; Macrae, Rhiannon K.; Koonin, Eugene V.; Zhang, Feng
作者单位：Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM)
摘要：Microbial systems underpin many biotechnologies, including CRISPR, but the exponential growth of sequence databases makes it difficult to find previously unidentified systems. In this work, we develop the fast locality-sensitive hashing-based clustering (FLSHclust) algorithm, which performs deep clustering on massive datasets in linearithmic time. We incorporated FLSHclust into a CRISPR discovery pipeline and identified 188 previously unreported CRISPR-linked gene modules, revealing many addit...
